Published in Nature on July 27, 2014
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature (2014) 5.19
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Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning. Science (2015) 1.15
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The structural biology of CRISPR-Cas systems. Curr Opin Struct Biol (2015) 1.07
Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature (2016) 1.05
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Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch. Nat Biotechnol (2016) 0.94
Modulating the Cascade architecture of a minimal Type I-F CRISPR-Cas system. Nucleic Acids Res (2016) 0.94
Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements. Genome Biol (2015) 0.93
Efficient Multiple Genome Modifications Induced by the crRNAs, tracrRNA and Cas9 Protein Complex in Zebrafish. PLoS One (2015) 0.93
Synthesis of an arrayed sgRNA library targeting the human genome. Sci Rep (2015) 0.93
DSSR: an integrated software tool for dissecting the spatial structure of RNA. Nucleic Acids Res (2015) 0.92
In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Mol Ther (2015) 0.92
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity. Mol Cell (2016) 0.91
Enabling functional genomics with genome engineering. Genome Res (2015) 0.90
Cas9 Variants Expand the Target Repertoire in Caenorhabditis elegans. Genetics (2015) 0.90
Cas9-based genome editing in Xenopus tropicalis. Methods Enzymol (2014) 0.89
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems. Mol Cell (2016) 0.89
Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli. Nucleic Acids Res (2015) 0.88
DNA-binding-domain fusions enhance the targeting range and precision of Cas9. Nat Methods (2015) 0.88
Structure and Engineering of Francisella novicida Cas9. Cell (2016) 0.88
In vitro enzymology of Cas9. Methods Enzymol (2014) 0.87
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med (2015) 0.87
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage. Nucleic Acids Res (2015) 0.86
DNase H Activity of Neisseria meningitidis Cas9. Mol Cell (2015) 0.85
"Off-Spotter": very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs. Biol Direct (2015) 0.84
Probing the impact of chromatin conformation on genome editing tools. Nucleic Acids Res (2016) 0.84
Sequence features associated with the cleavage efficiency of CRISPR/Cas9 system. Sci Rep (2016) 0.84
Consequences of Cas9 cleavage in the chromosome of Escherichia coli. Nucleic Acids Res (2016) 0.84
Applications of CRISPR-Cas9 mediated genome engineering. Mil Med Res (2015) 0.84
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome. Mol Ther (2015) 0.84
The therapeutic application of CRISPR/Cas9 technologies for HIV. Expert Opin Biol Ther (2015) 0.83
A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation. PLoS Comput Biol (2016) 0.83
Data-collection strategy for challenging native SAD phasing. Acta Crystallogr D Struct Biol (2016) 0.83
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Res (2016) 0.82
Engineering canker-resistant plants through CRISPR/Cas9-targeted editing of the susceptibility gene CsLOB1 promoter in citrus. Plant Biotechnol J (2017) 0.82
Multigene disruption in undomesticated Bacillus subtilis ATCC 6051a using the CRISPR/Cas9 system. Sci Rep (2016) 0.81
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. Nat Commun (2016) 0.81
Target DNA recognition and cleavage by a reconstituted Type I-G CRISPR-Cas immune effector complex. Extremophiles (2016) 0.81
Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease. Nat Commun (2016) 0.81
CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo. Mol Ther (2017) 0.80
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target. Methods Enzymol (2015) 0.80
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes. Annu Rev Biophys (2015) 0.80
Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells. Biol Direct (2016) 0.79
CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells. Biomed Res Int (2015) 0.79
Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations. ACS Cent Sci (2016) 0.79
CRISPR/Cas9: molecular tool for gene therapy to target genome and epigenome in the treatment of lung cancer. Cancer Gene Ther (2015) 0.79
Cas9 Functionally Opens Chromatin. PLoS One (2016) 0.79
PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. Cell (2016) 0.79
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets. Nat Methods (2017) 0.78
Salient Features of Endonuclease Platforms for Therapeutic Genome Editing. Mol Ther (2016) 0.78
Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. Mol Cell (2016) 0.78
The history and market impact of CRISPR RNA-guided nucleases. Curr Opin Virol (2015) 0.78
The Rise of CRISPR/Cas for Genome Editing in Stem Cells. Stem Cells Int (2016) 0.78
Integration and exchange of split dCas9 domains for transcriptional controls in mammalian cells. Nat Commun (2016) 0.78
A decade of discovery: CRISPR functions and applications. Nat Microbiol (2017) 0.77
Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling. Cell Biochem Biophys (2016) 0.77
Single-Base Pair Genome Editing in Human Cells by Using Site-Specific Endonucleases. Int J Mol Sci (2015) 0.77
Targeting Non-Coding RNAs in Plants with the CRISPR-Cas Technology is a Challenge yet Worth Accepting. Front Plant Sci (2015) 0.77
Cas9 loosens its grip on off-target sites. Nat Biotechnol (2016) 0.77
Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases. Int J Mol Sci (2015) 0.77
Structural and dynamic views of the CRISPR-Cas system at the single-molecule level. BMB Rep (2016) 0.77
Mapping the genomic landscape of CRISPR-Cas9 cleavage. Nat Methods (2017) 0.76
One-step homozygosity in precise gene editing by an improved CRISPR/Cas9 system. Cell Res (2016) 0.76
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Interference activity of a minimal Type I CRISPR-Cas system from Shewanella putrefaciens. Nucleic Acids Res (2015) 0.76
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