Published in Genes Nutr on August 09, 2014
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Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum (2004) 2.04
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Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. Circulation (2005) 1.70
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The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis (2001) 1.53
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Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer. Cancer Epidemiol Biomarkers Prev (2006) 1.24
Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics (2004) 1.22
Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. Blood (2002) 1.21
Methionine synthase A2756G polymorphism and cancer risk: a meta-analysis. Eur J Hum Genet (2009) 1.17
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Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality. PLoS One (2013) 1.11
Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett (2003) 1.07
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. Pharmacogenomics J (2009) 1.04
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies. PLoS One (2012) 1.01
Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. Hum Mutat (2006) 1.01
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. Am J Clin Nutr (2008) 0.99
Conjoined twins--an epidemiological study based on 312 cases. The International Clearinghouse for Birth Defects Monitoring Systems. Acta Genet Med Gemellol (Roma) (1991) 0.97
Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One (2013) 0.96
Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. Eur J Clin Nutr (2010) 0.91
Neural tube defects in Latin America and the impact of fortification: a literature review. Public Health Nutr (2013) 0.90
High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab (1999) 0.90
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc (2009) 0.89
Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2). J Med Genet (2007) 0.87
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The supply of choline is important for fetal progenitor cells. Semin Cell Dev Biol (2011) 0.87
The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer. Int J Biol Sci (2012) 0.85
Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial. Hypertension (2013) 0.85
No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2008) 0.83
Differing effects of methylenetetrahydrofolate reductase single nucleotide polymorphisms on methotrexate efficacy and toxicity in rheumatoid arthritis. Pharmacogenetics (2002) 0.83
The maternal folate hydrolase gene polymorphism is associated with neural tube defects in a high-risk Chinese population. Genes Nutr (2012) 0.83
Homocysteine metabolism in families from southern Italy with neural tube defects: role of genetic and nutritional determinants. Prenat Diagn (2006) 0.81
Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia? J Hum Genet (2012) 0.81
Ultraviolet radiation represents an evolutionary selective pressure for the south-to-north gradient of the MTHFR 677TT genotype. Am J Clin Nutr (2006) 0.81
How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy. Cancer Lett (2014) 0.80
CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans. Mol Vis (2014) 0.80
The C677T polymorphism of the methylenetetrahydrofolate reductase gene in Mexican mestizo neural-tube defect parents, control mestizo and native populations. Ann Genet (2000) 0.80
Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR. J Hypertens (2010) 0.80
Red cell or serum folate: what to do in clinical practice? Clin Chem Lab Med (2013) 0.80
Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies. PLoS One (2013) 0.79
Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects. J Neurosurg Pediatr (2010) 0.79
Polymorphisms in MTHFR, MTHFD, and PAI-1 and recurrent miscarriage among North Indian women. Arch Gynecol Obstet (2013) 0.79
[Mortality from neural tube defects in Mexico, 1980-1997]. Salud Publica Mex (2003) 0.78
Analysis of polymorphisms in genes (AGT, MTHFR, GPIIIa, and GSTP1) associated with hypertension, thrombophilia and oxidative stress in Mestizo and Amerindian populations of México. Dis Markers (2010) 0.78
Distribution of alleles of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in familial spina bifida. Am J Med Genet (1999) 0.78
Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population. Metab Brain Dis (2011) 0.78
Head and neck carconogenesis: impact of MTHFD1 G1958A polymorphism. Rev Assoc Med Bras (2011) 0.77
The methionine synthase polymorphism c.2756A>G (D919G) influences diastolic blood pressure. J Hum Hypertens (2007) 0.76
Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up. Am J Clin Nutr (2012) 0.76
The burden of blood-pressure-related cardiovascular mortality in Mexico. Int J Hypertens (2014) 0.76
A genomewide admixture map for Latino populations. Am J Hum Genet (2007) 4.71
Reconstructing Native American population history. Nature (2012) 3.49
SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. Circulation (2007) 2.42
Association of the genetic marker for abacavir hypersensitivity HLA-B*5701 with HCP5 rs2395029 in Mexican Mestizos. Pharmacogenomics (2011) 1.97
High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab (2008) 1.76
Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet (2012) 1.75
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas. PLoS Genet (2012) 1.74
The FTO gene is associated with adulthood obesity in the Mexican population. Obesity (Silver Spring) (2008) 1.62
A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet (2010) 1.60
Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. Arterioscler Thromb Vasc Biol (2005) 1.46
Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors. Exp Biol Med (Maywood) (2009) 1.39
Physiological and molecular determinants of insulin action in the baboon. Diabetes (2008) 1.34
The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes (2007) 1.29
Founder effect for the Ala431Glu mutation of the presenilin 1 gene causing early-onset Alzheimer's disease in Mexican families. Neurogenetics (2006) 1.24
Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population. Diabetes (2012) 1.24
Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: the Alaska Siberia project. Int J Circumpolar Health (2005) 1.19
Fatty acid consumption and metabolic syndrome components: the GOCADAN study. J Cardiometab Syndr (2007) 1.16
Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes (2007) 1.16
Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome. Diabetes (2006) 1.15
The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study. PLoS One (2012) 1.08
Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons. Cardiovasc Diabetol (2009) 1.05
Individual saturated fatty acids are associated with different components of insulin resistance and glucose metabolism: the GOCADAN study. Int J Circumpolar Health (2010) 1.01
Genetic heterogeneity of autosomal dominant hypercholesterolemia in Mexico. Arch Med Res (2006) 0.99
Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One (2013) 0.96
Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.). Cardiovasc Diabetol (2010) 0.93
Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution. PLoS One (2012) 0.91
A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome. J Nutr (2011) 0.91
Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertens Res (2008) 0.90
Genomic medicine in Mexico: initial steps and the road ahead. Genome Res (2008) 0.90
PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population. PLoS One (2012) 0.89
Heart rate is associated with red blood cell fatty acid concentration: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Am Heart J (2010) 0.89
Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. Am J Clin Nutr (2010) 0.89
The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes. Hum Biol (2007) 0.88
Maternal MTHFR polymorphisms and risk of spontaneous abortion. Salud Publica Mex (2009) 0.87
Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment. Curr Opin Lipidol (2009) 0.85
Mutations in MODY genes are not common cause of early-onset type 2 diabetes in Mexican families. JOP (2005) 0.85
[Gene geography of Chile: regional distribution of American, European and African genetic contributions]. Rev Med Chil (2014) 0.84
Pleiotropic effects of genes for insulin resistance on adiposity in baboons. Obes Res (2004) 0.84
Von Hippel-Lindau disease germline mutations in Mexican patients with cerebellar hemangioblastoma. J Neurosurg (2006) 0.83
LOC387761 polymorphism is associated with type 2 diabetes in the Mexican population. Genet Test Mol Biomarkers (2011) 0.82
Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers. J Med Primatol (2009) 0.82
Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women. J Nutr (2011) 0.82
Delta-sarcoglycan gene polymorphism frequency in Amerindian and Mestizo populations of Mexico. Genet Test Mol Biomarkers (2010) 0.81
Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. Gene (2013) 0.81
Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-alpha gene in Maya-Mestizo women with preeclampsia. Hypertens Pregnancy (2007) 0.81
Polyunsaturated fatty acids effect on serum triglycerides concentration in the presence of metabolic syndrome components. The Alaska-Siberia Project. Metabolism (2009) 0.80
Combined effect of plant sterols and dietary fiber for the treatment of hypercholesterolemia. Plant Foods Hum Nutr (2014) 0.80
Founder effect and ancestral origin of the spinocerebellar ataxia type 7 (SCA7) mutation in Mexican families. Neurogenetics (2013) 0.80
The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: an association beyond HDL cholesterol. Curr Diabetes Rev (2007) 0.80
Genome-wide scan of plasma cholecystokinin in baboons shows linkage to human chromosome 17. Obesity (Silver Spring) (2007) 0.80
Resequencing, haplotype construction and identification of novel variants of CYP2D6 in Mexican Mestizos. Pharmacogenomics (2011) 0.80
Biomarkers of nutrient bioactivity and efficacy: a route toward personalized nutrition. J Clin Gastroenterol (2012) 0.80
Analysis of polymorphisms in interleukin-10, interleukin-6, and interleukin-1 receptor antagonist in Mexican-Mestizo women with pre-eclampsia. Genet Test Mol Biomarkers (2012) 0.79
Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta (2010) 0.79
Fibroblast growth factor receptor 1 (FGFR1) variants and craniofacial variation in Amerindians and related populations. Am J Hum Biol (2012) 0.79
Endothelial nitric oxide synthase haplotypes are associated with preeclampsia in Maya mestizo women. Dis Markers (2011) 0.79
The non-synonymous Arg230Cys variant (R230C) of the ATP-binding cassette transporter A1 is associated with low HDL cholesterol concentrations in Mexican adults: a population based nation wide study. Atherosclerosis (2011) 0.79
PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations. Mol Biol Rep (2014) 0.78
Analysis of polymorphisms in genes (AGT, MTHFR, GPIIIa, and GSTP1) associated with hypertension, thrombophilia and oxidative stress in Mestizo and Amerindian populations of México. Dis Markers (2010) 0.78
Facial asymmetry and genetic ancestry in Latin American admixed populations. Am J Phys Anthropol (2015) 0.78
VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children. PLoS One (2012) 0.78
Identification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase. Biochem Genet (2010) 0.78
Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia. Clin Biochem (2013) 0.78
Hepatic amino acid-degrading enzyme expression is downregulated by natural and synthetic ligands of PPARα in rats. J Nutr (2013) 0.77
Characterization of ghrelin in pedigreed baboons: evidence for heritability and pleiotropy. Obesity (Silver Spring) (2008) 0.77
GPDTI: a Genetic Programming Decision Tree induction method to find epistatic effects in common complex diseases. Bioinformatics (2007) 0.77
[Succesful collaborations between three Mexican institutions for research on dislipidemias, obesity and diabetes]. Gac Med Mex (2008) 0.76
PPARγ2 Pro12Ala polymorphism is associated with improved lipoprotein lipase functioning in adipose tissue of insulin resistant obese women. Gene (2012) 0.76
Increase in HDL-C concentration by a dietary portfolio with soy protein and soluble fiber is associated with the presence of the ABCA1R230C variant in hyperlipidemic Mexican subjects. Mol Genet Metab (2010) 0.76
Correction: Socioeconomic Status Is Not Related with Facial Fluctuating Asymmetry: Evidence from Latin-American Populations. PLoS One (2017) 0.75
[New perspectives in long QT syndrome]. Rev Invest Clin (2007) 0.75
Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations. Mol Biol Rep (2013) 0.75