Studying epithelial morphogenesis in Dictyostelium.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature (2011) 9.61

Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18

Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev (2006) 5.45

Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature (2011) 5.35

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science (2003) 5.23

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta (2007) 4.74

A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11

Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature (2012) 3.83

Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76

Structure of the δ-opioid receptor bound to naltrindole. Nature (2012) 3.69

Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol (2008) 3.63

Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60

Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19

Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol (2007) 2.86

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol (2004) 2.83

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity. Bioessays (2012) 2.81

Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol (2004) 2.59

Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol (2003) 2.55

Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53

Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49

High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38

A mitotic septin scaffold required for Mammalian chromosome congression and segregation. Science (2005) 2.37

Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33

Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem (2002) 2.31

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28

The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22

Re-solving the cadherin-catenin-actin conundrum. J Biol Chem (2006) 2.19

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature (2013) 2.14

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13

Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol (2002) 1.97

beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96

Characterizing the initial encounter complex in cadherin adhesion. Structure (2009) 1.90

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell (2002) 1.88

A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity. J Cell Biol (2007) 1.87

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One (2008) 1.86

Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes. J Cell Sci (2004) 1.83

Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells. J Cell Sci (2004) 1.82

AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. J Cell Biol (2010) 1.81

Resolving cadherin interactions and binding cooperativity at the single-molecule level. Proc Natl Acad Sci U S A (2008) 1.81

Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis. Semin Cancer Biol (2007) 1.76

Two distinct modes of myosin assembly and dynamics during epithelial wound closure. J Cell Biol (2007) 1.74

Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol Biol Cell (2007) 1.69

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Proc Natl Acad Sci U S A (2010) 1.68

Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J Cell Biol (2008) 1.65

Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem (2007) 1.65

Here come the septins: novel polymers that coordinate intracellular functions and organization. J Cell Sci (2006) 1.60

X-ray structure determination at low resolution. Acta Crystallogr D Biol Crystallogr (2009) 1.60

A monoclonal antibody for G protein-coupled receptor crystallography. Nat Methods (2007) 1.60

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev Cell (2011) 1.57

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature (2016) 1.55

Immediate-early signaling induced by E-cadherin engagement and adhesion. J Biol Chem (2007) 1.54

APC is a component of an organizing template for cortical microtubule networks. Nat Cell Biol (2005) 1.54

Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. Mol Biol Cell (2002) 1.54

Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. J Biol Chem (2004) 1.53

VE-cadherin: at the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol (2010) 1.49

Forchlorfenuron alters mammalian septin assembly, organization, and dynamics. J Biol Chem (2008) 1.43

Cell-adhesion assays: fabrication of an E-cadherin substratum and isolation of lateral and Basal membrane patches. Methods Mol Biol (2005) 1.40

In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.37

Crystal structure of the S.cerevisiae exocyst component Exo70p. J Mol Biol (2005) 1.37

Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. Nature (2007) 1.36

Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J Cell Sci (2005) 1.34

Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane. J Cell Sci (2002) 1.33

A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. Science (2011) 1.32

Biochemical and structural analysis of alpha-catenin in cell-cell contacts. Biochem Soc Trans (2008) 1.32

αE-catenin is an autoinhibited molecule that coactivates vinculin. Proc Natl Acad Sci U S A (2012) 1.25

Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization. Semin Cell Dev Biol (2008) 1.24

Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro. Mol Biol Cell (2007) 1.22

Fractionation of the epithelial apical junctional complex: reassessment of protein distributions in different substructures. Mol Biol Cell (2004) 1.21

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors. Elife (2013) 1.20

Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18

Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells. J Biol Chem (2002) 1.17

N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One (2012) 1.17

Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J Biol Chem (2006) 1.17

Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle. J Biol Chem (2013) 1.15

Breaking into the epithelial apical-junctional complex--news from pathogen hackers. Curr Opin Cell Biol (2004) 1.15

The cytoplasmic face of cell contact sites. Curr Opin Struct Biol (2002) 1.14

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Proc Natl Acad Sci U S A (2002) 1.10

Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol (2004) 1.10