What are our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 25419472)

Published in AJOB Prim Res on January 01, 2012

Authors

Joon-Ho Yu1, Janelle S Taylor2, Karen L Edwards3, Stephanie M Fullerton4

Author Affiliations

1: Senior Fellow, Department of Pediatrics, School of Medicine, University of Washington, Box 356320, 1959 NE Pacific St. HSB RR349, Seattle, WA 98195, joonhoyu@u.washington.edu.
2: Associate Professor, University of Washington - Anthropology, Seattle, WA, jstaylor@u.washington.edu.
3: Professor, University of Washington - Epidemiology, Seattle, WA, keddy@u.washington.edu.
4: Associate Professor, University of Washington - Bioethics & Humanities, Seattle, WA, smfllrtn@u.washington.edu.

Articles citing this

Health and genetic ancestry testing: time to bridge the gap. BMC Med Genomics (2017) 0.75

Articles cited by this

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94

Genetic structure of human populations. Science (2002) 30.91

Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet (1999) 23.67

Association mapping in structured populations. Am J Hum Genet (2000) 16.79

Replicating genotype-phenotype associations. Nature (2007) 16.11

Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99

New approaches to population stratification in genome-wide association studies. Nat Rev Genet (2010) 7.97

Ethnic-affiliation estimation by use of population-specific DNA markers. Am J Hum Genet (1997) 6.72

Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet (2011) 4.93

Human population genetic structure and inference of group membership. Am J Hum Genet (2003) 4.73

The ethos and ethics of translational research. Am J Bioeth (2008) 4.73

Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet (2003) 4.67

Mapping by admixture linkage disequilibrium: advances, limitations and guidelines. Nat Rev Genet (2005) 4.04

Linkage disequilibrium in admixed populations: applications in gene mapping. J Hered (1994) 3.46

A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications. Hum Mutat (2008) 2.96

CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification? Hum Genet (2002) 2.90

Prospects for admixture mapping of complex traits. Am J Hum Genet (2004) 2.73

Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine. Hum Genet (2005) 2.67

Polymorphic admixture typing in human ethnic populations. Am J Hum Genet (1994) 2.37

Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations. Hum Genet (2005) 2.19

Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE. Genet Epidemiol (2005) 2.09

Genetic ancestry and the search for personalized genetic histories. Nat Rev Genet (2004) 2.08

Human population structure and genetic association studies. Pharmacogenomics (2003) 2.00

Genetics. The science and business of genetic ancestry testing. Science (2007) 1.95

An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels. BMC Genet (2009) 1.80

A marker for Stevens-Johnson syndrome ...: ethnicity matters. Pharmacogenomics J (2006) 1.73

The use of racial, ethnic, and ancestral categories in human genetics research. Am J Hum Genet (2005) 1.73

The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. Am Psychol (2005) 1.71

Medicine. Race and reification in science. Science (2005) 1.66

Different differences: the use of 'genetic ancestry' versus race in biomedical human genetic research. Soc Stud Sci (2011) 1.63

Race and ancestry in biomedical research: exploring the challenges. Genome Med (2009) 1.55

Ancestry estimation and correction for population stratification in molecular epidemiologic association studies. Cancer Epidemiol Biomarkers Prev (2008) 1.43

Race and ethnicity in the genome era: the complexity of the constructs. Am Psychol (2005) 1.36

Race, genetic West African ancestry, and prostate cancer prediction by prostate-specific antigen in prospectively screened high-risk men. Cancer Prev Res (Phila) (2009) 1.36

Inferring genetic ancestry: opportunities, challenges, and implications. Am J Hum Genet (2010) 1.36

Non-Darwinian estimation: my ancestors, my genes' ancestors. Genome Res (2009) 1.35

The beauty of admixture. Nat Genet (2005) 1.33

Markers that discriminate between European and African ancestry show limited variation within Africa. Hum Genet (2002) 1.27

Self-reported ethnicity, genetic structure and the impact of population stratification in a multiethnic study. Hum Genet (2010) 1.26

Admixture mapping as a tool in gene discovery. Curr Opin Genet Dev (2007) 1.23

Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine. PLoS One (2011) 1.21

Bio science: genetic genealogy testing and the pursuit of African ancestry. Soc Stud Sci (2008) 1.19

The biologistical construction of race: 'admixture' technology and the new genetic medicine. Soc Stud Sci (2008) 1.14

Genetics. The illusive gold standard in genetic ancestry testing. Science (2009) 1.07

"Race" and "ethnicity" in biomedical research: how do scientists construct and explain differences in health? Soc Sci Med (2009) 1.01

Physicians' attitudes toward race, genetics, and clinical medicine. Genet Med (2009) 1.01

Race, genetics, and disease: questions of evidence, matters of consequence. Soc Stud Sci (2008) 0.98

The changing face of "misidentified paternity". J Med Philos (2007) 0.95

Ethnicity, ancestry, and race in molecular epidemiologic research. Cancer Epidemiol Biomarkers Prev (2005) 0.94

Theoretical formulation of principal components analysis to detect and correct for population stratification. PLoS One (2010) 0.93

CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification. Cancer Res (2009) 0.90

Population description and its role in the interpretation of genetic association. Hum Genet (2010) 0.90

Population stratification in a case-control study of brain arteriovenous malformation in Latinos. Neuroepidemiology (2008) 0.89

Primary care physicians' attitudes regarding race-based therapies. J Gen Intern Med (2010) 0.88

Translational genomics: seeking a shared vision of benefit. Am J Bioeth (2008) 0.86

Race as a social construct in head and neck cancer outcomes. Otolaryngol Head Neck Surg (2011) 0.84

Genotyping the future: scientists' expectations about race/ ethnicity after BiDil. J Law Med Ethics (2008) 0.80

Pharmacogenomics research involving racial classification: qualitative research findings on researchers' views, perceptions and attitudes towards socioethical responsibilities. Pharmacogenomics (2007) 0.80

Ancestral links of Chesapeake Bay region African Americans to specific Bight of Bonny (West Africa) microethnic groups and increased frequency of aggressive breast cancer in both regions. Am J Hum Biol (2008) 0.78

Interpreting the implications of DNA ancestry tests. Perspect Biol Med (2010) 0.78

For Asians only? The perils of ancestry-based drug prescribing. J Law Med Ethics (2008) 0.78