AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

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Published in Nat Cell Biol on December 01, 2014

Authors

Valentina Cianfanelli1, Claudia Fuoco2, Mar Lorente3, Maria Salazar3, Fabio Quondamatteo4, Pier Federico Gherardini2, Daniela De Zio5, Francesca Nazio6, Manuela Antonioli7, Melania D'Orazio2, Tatjana Skobo8, Matteo Bordi6, Mikkel Rohde9, Luisa Dalla Valle8, Manuela Helmer-Citterich2, Christine Gretzmeier10, Joern Dengjel10, Gian Maria Fimia11, Mauro Piacentini7, Sabrina Di Bartolomeo2, Guillermo Velasco3, Francesco Cecconi12

Author Affiliations

1: 1] Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark [2] Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy.
2: Department of Biology, University of Rome 'Tor Vergata', 00133 Rome, Italy.
3: 1] Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain [2] Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
4: Skin and Extracellular Matrix Research Group, Anatomy NUI Galway, Ireland.
5: Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
6: Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy.
7: 1] Department of Biology, University of Rome 'Tor Vergata', 00133 Rome, Italy [2] National Institute for Infectious Diseases IRCCS 'L. Spallanzani', 00149 Rome, Italy.
8: Department of Biology, University of Padua, 35131 Padua, Italy.
9: Unit of Cell Death and Metabolism, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
10: 1] Department of Dermatology, University Freiburg Medical Center, 79104 Freiburg, Germany [2] ZBSA Center for Biological Systems Analysis, University of Freiburg, 79104 Freiburg, Germany.
11: 1] National Institute for Infectious Diseases IRCCS 'L. Spallanzani', 00149 Rome, Italy [2] Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce 73100, Italy.
12: 1] Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark [2] Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy [3] Department of Biology, University of Rome 'Tor Vergata', 00133 Rome, Italy.

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