Published in Cell Adh Migr on January 01, 2014
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue. Cell Rep (2015) 0.77
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med (2016) 0.75
Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice. Theranostics (2016) 0.75
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 23.44
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
Drug penetration in solid tumours. Nat Rev Cancer (2006) 9.80
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 7.57
Cancer invasion and the microenvironment: plasticity and reciprocity. Cell (2011) 6.36
The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res (2006) 4.83
Visualizing the mechanical activation of Src. Nature (2005) 4.63
Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods (2008) 4.13
Integrin regulation. Curr Opin Cell Biol (2005) 3.80
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology (2005) 3.18
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut (2012) 3.13
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature (2014) 3.09
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res (2008) 2.66
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol (2012) 2.59
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun (2013) 2.31
Cancer stem cell niche: the place to be. Cancer Res (2011) 2.14
Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther (2008) 1.96
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity. Curr Biol (2001) 1.81
Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart (2005) 1.55
Imaging activation of two Ras isoforms simultaneously in a single cell. Chembiochem (2005) 1.54
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Res (2010) 1.50
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays. Nat Methods (2010) 1.34
Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy. J Biophotonics (2010) 1.30
Tumour regulation of fibroblast hyaluronan expression: a mechanism to facilitate tumour growth and invasion. Carcinogenesis (2005) 1.28
Determinants of drug delivery and transport to solid tumors. J Control Release (2001) 1.24
Multiplexed FRET to image multiple signaling events in live cells. Biophys J (2008) 1.23
Surgical implantation of an abdominal imaging window for intravital microscopy. Nat Protoc (2013) 1.19
An orange fluorescent protein with a large Stokes shift for single-excitation multicolor FCCS and FRET imaging. J Am Chem Soc (2012) 1.16
Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib. Cancer Res (2007) 1.14
Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor. Cancer Res (2005) 1.11
Intravital analysis of vascular permeability in mice using two-photon microscopy. Sci Rep (2013) 1.11
Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels (2010) 1.10
Quantitative analysis of collagen and collagen subtypes I, III, and V in human pancreatic cancer, tumor-associated chronic pancreatitis, and alcoholic chronic pancreatitis. Pancreas (1995) 1.05
Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context. J Vis Exp (2011) 0.99
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. Cancer Res (2013) 0.99
Antiangiogenesis enhances intratumoral drug retention. Cancer Res (2011) 0.95
The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Rep (2014) 0.91
Real-time visualization and quantitation of vascular permeability in vivo: implications for drug delivery. PLoS One (2012) 0.85
FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion. Small GTPases (2011) 0.84
Elastin-derived peptides enhance melanoma growth in vivo by upregulating the activation of Mcol-A (MMP-1) collagenase. Br J Cancer (2010) 0.82
Blocking of endothelial-leukocyte interaction (rolling) does not improve reflow in the rat gastric mucosa after hemorrhagic shock and retransfusion. Shock (1994) 0.78
Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue. FEBS J (2013) 0.77
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84
Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell (2005) 3.26
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol (2013) 2.98
Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events. Nat Immunol (2011) 2.75
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell (2011) 2.40
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
Polyene-lipids: a new tool to image lipids. Nat Methods (2004) 2.30
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits. J Cell Sci (2005) 1.89
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol (2004) 1.81
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. J Pathol (2010) 1.79
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
PALM imaging and cluster analysis of protein heterogeneity at the cell surface. J Biophotonics (2010) 1.76
Nanometer targeting of microtubules to focal adhesions. J Cell Biol (2003) 1.69
p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J (2003) 1.68
Safety and efficacy of prophylactic anticoagulation in patients with traumatic brain injury. J Am Coll Surg (2011) 1.67
MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clin Cancer Res (2011) 1.57
Quantitative imaging of membrane lipid order in cells and organisms. Nat Protoc (2011) 1.55
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol (2012) 1.45
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Curr Biol (2010) 1.34
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest (2014) 1.33
Recent advances using green and red fluorescent protein variants. Appl Microbiol Biotechnol (2007) 1.27
Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res (2009) 1.25
The lipid raft hypothesis revisited--new insights on raft composition and function from super-resolution fluorescence microscopy. Bioessays (2012) 1.24
Multiplexed FRET to image multiple signaling events in live cells. Biophys J (2008) 1.23
Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution. Nat Commun (2012) 1.22
CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells. Mol Cell Biol (2002) 1.21
Activation of the IL-6R/Jak/stat pathway is associated with a poor outcome in resected pancreatic ductal adenocarcinoma. J Gastrointest Surg (2013) 1.15
Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle (2012) 1.14
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep (2010) 1.14
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res (2010) 1.12
Mechanically induced actin-mediated rocketing of phagosomes. Mol Biol Cell (2006) 1.10
Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motil Cytoskeleton (2006) 1.10
Hybridization of electronic states in quantum dots through photon emission. Nature (2004) 1.09
High speed unsupervised fluorescence lifetime imaging confocal multiwell plate reader for high content analysis. J Biophotonics (2008) 1.07
The leading edge is a lipid diffusion barrier. J Cell Sci (2005) 1.07
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Curr Biol (2012) 1.05
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. Elife (2013) 1.01
Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus. Oncogene (2005) 1.00
Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context. J Vis Exp (2011) 0.99
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. Cancer Res (2013) 0.99
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity. Nat Cell Biol (2012) 0.97
Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLoS One (2009) 0.97
The relative importance of topography and RGD ligand density for endothelial cell adhesion. PLoS One (2011) 0.97
Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion. Angew Chem Int Ed Engl (2012) 0.96
Imaging membrane lipid order in whole, living vertebrate organisms. Biophys J (2010) 0.96
Imaging molecular dynamics in vivo--from cell biology to animal models. J Cell Sci (2011) 0.93
Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity. Mol Cell Biol (2013) 0.92
Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS One (2012) 0.91
Smart tissue culture: in situ monitoring of the activity of protease enzymes secreted from live cells using nanostructured photonic crystals. Nano Lett (2009) 0.91
Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. Br J Pharmacol (2015) 0.90
Neuropathic pain associated with non-surgical treatment of breast cancer. Pain (2005) 0.90
Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell (2007) 0.89
Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle. J Gen Physiol (2009) 0.89
Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane. Cell Adh Migr (2011) 0.88
Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. J Pathol (2013) 0.86
α- and β-crystallins modulate the head group order of human lens membranes during aging. Invest Ophthalmol Vis Sci (2010) 0.85
Mesoporous silicon photonic crystal microparticles: towards single-cell optical biosensors. Faraday Discuss (2011) 0.85
The multi-FERM-domain-containing protein FrmA is required for turnover of paxillin-adhesion sites during cell migration of Dictyostelium. J Cell Sci (2008) 0.84
FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion. Small GTPases (2011) 0.84
How do cells make decisions: engineering micro- and nanoenvironments for cell migration. J Oncol (2010) 0.84
Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling. PLoS One (2011) 0.83
Actin microridges characterized by laser scanning confocal and atomic force microscopy. FEBS Lett (2005) 0.83
Regulation of Tbx22 during facial and palatal development. Dev Dyn (2010) 0.83
Optical techniques for imaging membrane domains in live cells (live-cell palm of protein clustering). Methods Enzymol (2012) 0.81
Spacing of integrin ligands influences signal transduction in endothelial cells. Biophys J (2011) 0.81
Characterizing system performance in total internal reflection fluorescence microscopy. Methods Mol Biol (2011) 0.81
Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo. Cell Adh Migr (2009) 0.80
Fluorescence lifetime imaging: association of cortical actin with a PIP3-rich membrane compartment. Eur J Cell Biol (2008) 0.80
Live cell in vitro and in vivo imaging applications: accelerating drug discovery. Pharmaceutics (2011) 0.79
Quantitative analysis of three-dimensional fluorescence localization microscopy data. Biophys J (2013) 0.79
Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. Small GTPases (2011) 0.79