Topoisomerase-targeting antitumor drugs.

PubWeight™: 1.92‹?› | Rank: Top 3%

🔗 View Article (PMID 2557085)

Published in Biochim Biophys Acta on December 17, 1989

Authors

P D'Arpa1, L F Liu

Author Affiliations

1: Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Articles citing this

Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda. Microbiol Mol Biol Rev (1999) 6.92

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med (2006) 5.80

Single-strand interruptions in replicating chromosomes cause double-strand breaks. Proc Natl Acad Sci U S A (2001) 2.31

DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination. Proc Natl Acad Sci U S A (2001) 2.11

Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging. Biomaterials (2008) 1.70

Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. J Cell Biol (1994) 1.36

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase. Proc Natl Acad Sci U S A (1994) 1.34

Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin Microbiol Rev (1999) 1.21

Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet (2008) 1.19

Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives. Biochem J (1992) 1.19

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.18

Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies. Am J Pathol (1995) 1.17

Inhibition of human immunodeficiency virus integrase by bis-catechols. Antimicrob Agents Chemother (1995) 1.15

High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction. Br J Cancer (2009) 1.08

Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex. Proc Natl Acad Sci U S A (1994) 1.06

Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitors. EMBO J (1993) 1.01

Selection of a subpopulation with fewer DNA topoisomerase II alpha gene copies in a doxorubicin-resistant cell line panel. Br J Cancer (1996) 1.00

Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury. Free Radic Biol Med (2007) 0.99

Processing of damaged DNA ends for double-strand break repair in mammalian cells. ISRN Mol Biol (2012) 0.98

Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical development. Br J Cancer (1997) 0.98

A phase I study of paclitaxel, topotecan, cisplatin and Filgrastim in patients with newly diagnosed advanced ovarian epithelial malignancies: a Gynecologic Oncology Group study. Gynecol Oncol (2007) 0.98

Using breast cancer cell CXCR4 surface expression to predict liposome binding and cytotoxicity. Biomaterials (2012) 0.97

Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide. Br J Cancer (1997) 0.95

Quantitative confocal spectral imaging analysis of mitoxantrone within living K562 cells: intracellular accumulation and distribution of monomers, aggregates, naphtoquinoxaline metabolite, and drug-target complexes. Biophys J (1997) 0.93

Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative. Nucleic Acids Res (1991) 0.92

Localization and molecular interactions of mitoxantrone within living K562 cells as probed by confocal spectral imaging analysis. Biophys J (1997) 0.92

Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: influence of growth kinetics, growth environment and DNA packaging. Br J Cancer (1993) 0.90

Acidic pH induces topoisomerase II-mediated DNA damage. Proc Natl Acad Sci U S A (2003) 0.87

Using yeast to study resistance to topoisomerase II-targeting drugs. Cancer Chemother Pharmacol (1994) 0.87

Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites. Environ Health Perspect (1996) 0.86

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation. DNA Repair (Amst) (2008) 0.82

Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae. Mol Genet Genomics (2004) 0.82

Effect of P-glycoprotein modulators on the pharmacokinetics of camptothecin using microdialysis. Br J Pharmacol (2001) 0.82

Integration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide). Mol Cell Biol (1993) 0.81

Autonomous parvovirus DNA replication requires topoisomerase I and its activity is increased during infection. J Virol (1991) 0.80

A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning. Proc Natl Acad Sci U S A (1997) 0.80

The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli. J Bacteriol (2008) 0.80

Purification and characterization of a proteolytic active fragment of DNA topoisomerase I from the brine shrimp Artemia franciscana (Crustacea Anostraca). Biochem J (1992) 0.79

Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II. J Exp Med (1992) 0.79

Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha. Nucleic Acids Res (2003) 0.79

Clinical, pharmacokinetic and biological studies of topotecan. Cancer Chemother Pharmacol (1994) 0.79

Phase I and pharmacological study of the new topoisomerase I inhibitor GI147211, using a daily x 5 intravenous administration. Br J Cancer (1996) 0.79

Topoisomerase I inhibitors and drug resistance. Cytotechnology (1998) 0.78

The reversible DNA-alkylating activity of duocarmycin and its analogues. Nucleic Acids Res (1994) 0.78

Review of the management of relapsed small-cell lung cancer with amrubicin hydrochloride. Clin Med Insights Oncol (2011) 0.78

Structure-activity relationships of VP-16 analogues. Cancer Chemother Pharmacol (1994) 0.78

DNA of a circular minichromosome linearized by restriction enzymes or other reagents is resistant to further cleavage: an influence of chromatin topology on the accessibility of DNA. Nucleic Acids Res (2012) 0.77

Functions of Fun30 chromatin remodeler in regulating cellular resistance to genotoxic stress. PLoS One (2015) 0.76

Expression profiling and putative mechanisms of resistance to doxorubicin of human lung cancer cells. Dokl Biochem Biophys (2010) 0.76

Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors. PLoS One (2013) 0.76

A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B. Sci Rep (2017) 0.75

The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS One (2015) 0.75

Expression of anionic glutathione S transferase (GST pi) gene in carcinomas of the uterine cervix and in normal cervices. Br J Cancer (1991) 0.75

Inhibition of cancer antioxidant defense by natural compounds. Oncotarget (2016) 0.75

A phase I study of topotecan and gemcitabine in advanced solid tumors. Invest New Drugs (2010) 0.75

Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells. Cancer Chemother Pharmacol (1994) 0.75

Articles by these authors

(truncated to the top 100)

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60

Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73

Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00

Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res (1989) 4.01

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc Natl Acad Sci U S A (1981) 3.98

Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell (1980) 3.83

Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. J Biol Chem (1978) 3.35

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res (1988) 3.26

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21

DNA topoisomerases: essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol (1994) 3.18

A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem (1981) 3.07

Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05

Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies. Cell (1989) 3.00

Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol (2001) 2.97

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A (1984) 2.84

T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature (1979) 2.76

DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme. Cell (1978) 2.60

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res (1990) 2.49

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. Nucleic Acids Res (1981) 2.39

Integration of the DNA of filamentous bacteriophage Cflt into the chromosomal DNA of its host. J Virol (1987) 2.31

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26

On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. Biochim Biophys Acta (1975) 2.25

Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem (1996) 2.20

DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA. CRC Crit Rev Biochem (1983) 2.20

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science (1989) 2.11

Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. J Mol Biol (1976) 2.05

Purification and characterization of a type II DNA topoisomerase from bovine calf thymus. J Biol Chem (1985) 2.04

Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I. Proc Natl Acad Sci U S A (1995) 1.89

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 1.88

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. Cancer Res (1993) 1.88

Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA. Nucleic Acids Res (1982) 1.78

recA-independent and recA-dependent intramolecular plasmid recombination. Differential homology requirement and distance effect. J Mol Biol (1994) 1.72

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. Proc Natl Acad Sci U S A (1988) 1.70

Intra- and intermolecular strand transfer by HeLa DNA topoisomerase I. J Biol Chem (1982) 1.67

Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Cancer Res (2001) 1.63

Processing of topoisomerase I cleavable complexes into DNA damage by transcription. Nucleic Acids Res (1997) 1.63

Knotted DNA from bacteriophage capsids. Proc Natl Acad Sci U S A (1981) 1.59

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin. Cell (1985) 1.57

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem (1997) 1.56

Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells. Cancer Res (1985) 1.53

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin. Mol Cell Biol (1986) 1.52

26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J Biol Chem (2001) 1.50

Expression of alpha-amylases, carbohydrate metabolism, and autophagy in cultured rice cells is coordinately regulated by sugar nutrient. Plant J (1994) 1.49

SUMO-1 conjugation to human DNA topoisomerase II isozymes. J Biol Chem (2000) 1.48

Metabolic derepression of alpha-amylase gene expression in suspension-cultured cells of rice. J Biol Chem (1991) 1.48

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage. Proc Natl Acad Sci U S A (2000) 1.47

The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B. Cancer Res (1992) 1.42

Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives. J Med Chem (1993) 1.41

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. Cancer Res (1988) 1.41

Interaction between DNA and Escherichia coli DNA topoisomerase I. Formation of complexes between the protein and superhelical and nonsuperhelical duplex DNAs. J Biol Chem (1979) 1.41

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res (1989) 1.40

DNA topoisomerases as anticancer drug targets. Adv Pharmacol (1990) 1.38

Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor. EMBO J (1991) 1.34

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II. Cancer Res (1986) 1.33

DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. Cancer Res (1989) 1.31

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells. Nature (1986) 1.31

Identification of the breakage-reunion subunit of T4 DNA topoisomerase. J Biol Chem (1984) 1.31

Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons. J Biol Chem (1989) 1.31

DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors. Proc Natl Acad Sci U S A (1993) 1.30

DNA rearrangement mediated by inverted repeats. Proc Natl Acad Sci U S A (1996) 1.30

Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry (2001) 1.29

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev (1999) 1.25

Template supercoiling during ATP-dependent DNA helix tracking: studies with simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A (1989) 1.21

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. Cancer Res (1991) 1.20

Sugars act as signal molecules and osmotica to regulate the expression of alpha-amylase genes and metabolic activities in germinating cereal grains. Plant Mol Biol (1996) 1.19

ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB. Proc Natl Acad Sci U S A (1991) 1.18

A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures. Cancer Res (1993) 1.17

Hypernegative supercoiling of the DNA template during transcription elongation in vitro. J Biol Chem (1994) 1.16

Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res (1988) 1.16

Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. Cancer Res (1990) 1.16

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance. Cancer Res (1990) 1.15

Periodic ZnO nanorod arrays defined by polystyrene microsphere self-assembled monolayers. Nano Lett (2006) 1.14

Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. Nucleic Acids Res (1979) 1.13

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2. Proc Natl Acad Sci U S A (1988) 1.11

Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. Biochemistry (1999) 1.10

Inversion/dimerization of plasmids mediated by inverted repeats. J Mol Biol (1999) 1.10

DNA looping alters local DNA conformation during transcription. J Mol Biol (1991) 1.08

Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Nucleic Acids Res (1999) 1.07

A model for tumor cell killing by topoisomerase poisons. Cancer Cells (1990) 1.05

In vitro functional characterization of bacterially expressed human fibroblast tropomyosin isoforms and their chimeric mutants. Cell Motil Cytoskeleton (1993) 1.05

Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis. J Biol Chem (2001) 1.04

Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne. Cancer Res (1996) 1.03

Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins. Nucleic Acids Res (1983) 1.03

Topoisomerase II levels during granulocytic maturation in vitro and in vivo. Cancer Res (1991) 0.97

Atp-bound topoisomerase ii as a target for antitumor drugs. J Biol Chem (2001) 0.94

Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas. Cancer Res (1987) 0.93

Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res (1997) 0.93

Differentially and developmentally regulated expression of three rice sucrose synthase genes. Plant Cell Physiol (1999) 0.93

HeLa toposiomerase I. Methods Enzymol (1983) 0.92

A protein factor from Xenopus oocytes with simian virus 40 large tumor antigen-like DNA supercoiling activity. Proc Natl Acad Sci U S A (1990) 0.92

Tyr115, gln165 and trp209 contribute to the 1, 2-epoxy-3-(p-nitrophenoxy)propane-conjugating activity of glutathione S-transferase cGSTM1-1. J Mol Biol (2000) 0.92

A replicational model for DNA recombination between direct repeats. J Mol Biol (1996) 0.91

Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. Biochem Pharmacol (1997) 0.90

Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs. Mol Pharmacol (1989) 0.90

Ubiquitin, SUMO-1, and UCRP in camptothecin sensitivity and resistance. Ann N Y Acad Sci (2000) 0.89

Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. Eur J Biochem (1996) 0.89