Published in J Mol Biol on September 15, 1976
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Escherichia coli DNA topoisomerase I catalyzed linking of single-stranded rings of complementary base sequences. Nucleic Acids Res (1978) 1.46
Synthesis of a molecular trefoil knot by folding and closing on an octahedral coordination template. Nat Chem (2010) 1.22
Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex. Nucleic Acids Res (1980) 1.10
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A simple topological method for describing stereoisomers of DNA catenanes and knots. Proc Natl Acad Sci U S A (1984) 1.02
Escherichia coli strains containing mutations in the structural gene for topoisomerase I are recombination deficient. J Bacteriol (1984) 0.92
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DNA topoisomerase from Agrobacterium tumefaciens: purification and catalytic properties. Nucleic Acids Res (1981) 0.75
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Conformational fluctuations of DNA helix. Proc Natl Acad Sci U S A (1975) 8.72
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60
DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08
Helical repeat of DNA in solution. Proc Natl Acad Sci U S A (1979) 5.90
Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73
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The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline cesium chloride density gradients. J Mol Biol (1974) 5.44
Sequence dependence of the helical repeat of DNA in solution. Nature (1981) 5.21
Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71
Mapping the active site tyrosine of Escherichia coli DNA gyrase. J Biol Chem (1987) 4.68
Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase. J Mol Biol (1987) 4.66
Structure and mechanism of DNA topoisomerase II. Nature (1996) 4.56
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52
Variation of the average rotation angle of the DNA helix and the superhelical turns of covalently closed cyclic lambda DNA. J Mol Biol (1969) 4.48
Interactions between twisted DNAs and enzymes: the effects of superhelical turns. J Mol Biol (1974) 4.43
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med (1996) 4.42
Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling. Proc Natl Acad Sci U S A (1982) 4.35
Thermodynamic properties of superhelical DNAs. Biochemistry (1975) 4.20
Torsional rigidity of DNA and length dependence of the free energy of DNA supercoiling. J Mol Biol (1984) 4.03
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res (1989) 4.01
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98
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Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A (1997) 3.84
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell (1980) 3.83
On the probability of ring closure of lambda DNA. J Mol Biol (1966) 3.82
Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding. Cell (1982) 3.80
Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA. J Mol Biol (1966) 3.76
Energetics of B-to-Z transition in DNA. Proc Natl Acad Sci U S A (1983) 3.66
Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. J Biol Chem (1978) 3.35
Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA. J Biol Chem (1980) 3.31
DNA supercoiling and its effects on DNA structure and function. Cold Spring Harb Symp Quant Biol (1983) 3.29
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res (1988) 3.26
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
DNA topoisomerases: essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol (1994) 3.18
DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc Natl Acad Sci U S A (1988) 3.10
A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem (1981) 3.07
Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05
Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies. Cell (1989) 3.00
Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol (2001) 2.97
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A (1984) 2.84
Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Cell (1984) 2.80
T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature (1979) 2.76
Angular alteration of the DNA helix by E. coli RNA polymerase. Nat New Biol (1972) 2.75
Supercoiling of intracellular DNA can occur in eukaryotic cells. Cell (1988) 2.69
Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions. Cell (1983) 2.69
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome. Proc Natl Acad Sci U S A (1984) 2.69
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae. J Mol Biol (1999) 2.66
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Topoisomerase I interacts with transcribed regions in Drosophila cells. Cell (1986) 2.65
DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme. Cell (1978) 2.60
Deoxyribonucleic acid gyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an alpha 2 beta 2 protein core. Biochemistry (1980) 2.59
On the sequence determinants and flexibility of the kinetoplast DNA fragment with abnormal gel electrophoretic mobilities. J Mol Biol (1985) 2.57
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res (1990) 2.49
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature (1994) 2.48
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases. Cell (1992) 2.48
Knotting of a DNA chain during ring closure. Science (1993) 2.45
Use of light for footprinting DNA in vivo. Nature (1984) 2.42
Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loop. J Mol Biol (1985) 2.42
Mapping of single-stranded regions in duplex DNA at the sequence level: single-strand-specific cytosine methylation in RNA polymerase-promoter complexes. Proc Natl Acad Sci U S A (1983) 2.41
Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. Nucleic Acids Res (1981) 2.39
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings. Cell (1989) 2.37
Mapping the topography of DNA wrapped around gyrase by nucleolytic and chemical probing of complexes of unique DNA sequences. Cell (1981) 2.36
Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J Biol Chem (1989) 2.33
Integration of the DNA of filamentous bacteriophage Cflt into the chromosomal DNA of its host. J Virol (1987) 2.31
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. Biochim Biophys Acta (1975) 2.25
Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc Natl Acad Sci U S A (1985) 2.21
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. J Biol Chem (1998) 2.20
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem (1996) 2.20
Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science (1978) 2.20
DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA. CRC Crit Rev Biochem (1983) 2.20
Interaction between yeast sgs1 helicase and DNA topoisomerase III. J Biol Chem (2000) 2.19
DNA topoisomerase IIbeta and neural development. Science (2000) 2.14
Effect of circularity and superhelicity on transcription from bacteriophagelambda DNA. Proc Natl Acad Sci U S A (1973) 2.13
An omega protein from Drosophila melanogaster. Biochemistry (1974) 2.12
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science (1989) 2.11
Yeast DNA topoisomerase II. An ATP-dependent type II topoisomerase that catalyzes the catenation, decatenation, unknotting, and relaxation of double-stranded DNA rings. J Biol Chem (1982) 2.09
Role of Bacillus subtilis SpoIIIE in DNA transport across the mother cell-prespore division septum. Science (2000) 2.08
Degree of superhelicity of covalently closed cyclic DNA's from Escherichia coli. J Mol Biol (1969) 2.08
Physiochemical studies on interactions between DNA and RNA polymerase. Unwinding of the DNA helix by Escherichia coli RNA polymerase. Nucleic Acids Res (1977) 2.07
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Purification and characterization of a type II DNA topoisomerase from bovine calf thymus. J Biol Chem (1985) 2.04
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism. Cell (1994) 2.04
Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med (1997) 2.03
Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence. Cell (1985) 2.00
Measurements of unwinding of lac operator by repressor. Nature (1974) 1.98