Published in CRC Crit Rev Biochem on January 01, 1983
Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells. Mol Cell Biol (1985) 5.83
Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00
Localization of topoisomerase II in mitotic chromosomes. J Cell Biol (1985) 3.35
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A (1984) 2.84
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome. Proc Natl Acad Sci U S A (1984) 2.69
Topoisomerase II: A specific marker for cell proliferation. J Cell Biol (1986) 2.22
Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc Natl Acad Sci U S A (1985) 2.21
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA. EMBO J (1985) 1.89
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. Proc Natl Acad Sci U S A (1987) 1.72
Biochemical characteristics and physiological significance of major DNA topoisomerases. Antimicrob Agents Chemother (1989) 1.55
DNA gyrase complex with DNA: determinants for site-specific DNA breakage. EMBO J (1986) 1.52
Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents. Antimicrob Agents Chemother (1989) 1.51
DNA topoisomerase I is essential in Drosophila melanogaster. Proc Natl Acad Sci U S A (1993) 1.44
Chromatin structure, not DNA sequence specificity, is the primary determinant of topoisomerase II sites of action in vivo. Mol Cell Biol (1991) 1.32
Inhibition of DNA synthesis by aphidicolin induces supercoiling in simian virus 40 replicative intermediates. EMBO J (1985) 1.26
Isolation and characterization of the gene encoding Drosophila DNA topoisomerase II. Proc Natl Acad Sci U S A (1986) 1.18
Replication forks are underrepresented in chromosomal DNA of Xenopus laevis embryos. Proc Natl Acad Sci U S A (1986) 1.15
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs. Antimicrob Agents Chemother (1992) 1.09
Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase. Proc Natl Acad Sci U S A (1986) 1.03
Functional expression of a Drosophila gene in yeast: genetic complementation of DNA topoisomerase II. Proc Natl Acad Sci U S A (1988) 1.02
In vitro assays used to measure the activity of topoisomerases. Antimicrob Agents Chemother (1990) 0.98
Inhibition of HeLa cell DNA topoisomerase I by ATP and phosphate. Nucleic Acids Res (1985) 0.95
Mechanism of inhibition of mammalian DNA topoisomerase I by heparin. Biochem J (1987) 0.95
ATP inhibits nuclear and mitochondrial type I topoisomerases from human leukemia cells. Proc Natl Acad Sci U S A (1986) 0.94
Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation). EMBO J (1985) 0.92
Interaction of topoisomerase 1 with the transcribed region of the Drosophila HSP 70 heat shock gene. Nucleic Acids Res (1989) 0.88
Effects of the antitumor drug VP16 (etoposide) on the archaebacterial Halobacterium GRB 1.7 kb plasmid in vivo. Nucleic Acids Res (1987) 0.88
Archaebacterial reverse gyrase cleavage-site specificity is similar to that of eubacterial DNA topoisomerases I. Nucleic Acids Res (1990) 0.87
Aggregation of DNA by analogs of spermidine; enzymatic and structural studies. Nucleic Acids Res (1987) 0.85
DNA topoisomerase II activity in nonreplicating, transcriptionally inactive, chicken late spermatids. EMBO J (1989) 0.85
Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35. Clin Exp Immunol (2000) 0.84
Autonomous parvovirus DNA replication requires topoisomerase I and its activity is increased during infection. J Virol (1991) 0.80
The epsilon subunit of DNA polymerase III Is involved in the nalidixic acid-induced SOS response in Escherichia coli. J Bacteriol (2008) 0.80
Topoisomerase I inhibitors and drug resistance. Cytotechnology (1998) 0.78
Topoisomerase I is the predominant nuclear protein from avian erythrocytes that can be covalently linked to DNA. Biochem J (1985) 0.75
Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells. Proc Natl Acad Sci U S A (1986) 0.75
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60
Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73
Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res (1989) 4.01
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98
Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc Natl Acad Sci U S A (1981) 3.98
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell (1980) 3.83
Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. J Biol Chem (1978) 3.35
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res (1988) 3.26
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
DNA topoisomerases: essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol (1994) 3.18
A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem (1981) 3.07
Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05
Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies. Cell (1989) 3.00
Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol (2001) 2.97
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A (1984) 2.84
T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature (1979) 2.76
DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme. Cell (1978) 2.60
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res (1990) 2.49
Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. Nucleic Acids Res (1981) 2.39
Integration of the DNA of filamentous bacteriophage Cflt into the chromosomal DNA of its host. J Virol (1987) 2.31
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. Biochim Biophys Acta (1975) 2.25
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem (1996) 2.20
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science (1989) 2.11
Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. J Mol Biol (1976) 2.05
Purification and characterization of a type II DNA topoisomerase from bovine calf thymus. J Biol Chem (1985) 2.04
Topoisomerase-targeting antitumor drugs. Biochim Biophys Acta (1989) 1.92
Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I. Proc Natl Acad Sci U S A (1995) 1.89
Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 1.88
Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. Cancer Res (1993) 1.88
Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA. Nucleic Acids Res (1982) 1.78
recA-independent and recA-dependent intramolecular plasmid recombination. Differential homology requirement and distance effect. J Mol Biol (1994) 1.72
Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. Proc Natl Acad Sci U S A (1988) 1.70
Intra- and intermolecular strand transfer by HeLa DNA topoisomerase I. J Biol Chem (1982) 1.67
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Cancer Res (2001) 1.63
Processing of topoisomerase I cleavable complexes into DNA damage by transcription. Nucleic Acids Res (1997) 1.63
Knotted DNA from bacteriophage capsids. Proc Natl Acad Sci U S A (1981) 1.59
In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin. Cell (1985) 1.57
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem (1997) 1.56
Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells. Cancer Res (1985) 1.53
In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin. Mol Cell Biol (1986) 1.52
26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J Biol Chem (2001) 1.50
Expression of alpha-amylases, carbohydrate metabolism, and autophagy in cultured rice cells is coordinately regulated by sugar nutrient. Plant J (1994) 1.49
SUMO-1 conjugation to human DNA topoisomerase II isozymes. J Biol Chem (2000) 1.48
Metabolic derepression of alpha-amylase gene expression in suspension-cultured cells of rice. J Biol Chem (1991) 1.48
SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage. Proc Natl Acad Sci U S A (2000) 1.47
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B. Cancer Res (1992) 1.42
Interaction between DNA and Escherichia coli DNA topoisomerase I. Formation of complexes between the protein and superhelical and nonsuperhelical duplex DNAs. J Biol Chem (1979) 1.41
Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives. J Med Chem (1993) 1.41
Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. Cancer Res (1988) 1.41
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res (1989) 1.40
DNA topoisomerases as anticancer drug targets. Adv Pharmacol (1990) 1.38
Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor. EMBO J (1991) 1.34
DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II. Cancer Res (1986) 1.33
DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. Cancer Res (1989) 1.31
Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells. Nature (1986) 1.31
Identification of the breakage-reunion subunit of T4 DNA topoisomerase. J Biol Chem (1984) 1.31
Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons. J Biol Chem (1989) 1.31
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors. Proc Natl Acad Sci U S A (1993) 1.30
DNA rearrangement mediated by inverted repeats. Proc Natl Acad Sci U S A (1996) 1.30
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry (2001) 1.29
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev (1999) 1.25
Template supercoiling during ATP-dependent DNA helix tracking: studies with simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A (1989) 1.21
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. Cancer Res (1991) 1.20
Sugars act as signal molecules and osmotica to regulate the expression of alpha-amylase genes and metabolic activities in germinating cereal grains. Plant Mol Biol (1996) 1.19
ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB. Proc Natl Acad Sci U S A (1991) 1.18
A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures. Cancer Res (1993) 1.17
Hypernegative supercoiling of the DNA template during transcription elongation in vitro. J Biol Chem (1994) 1.16
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res (1988) 1.16
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. Cancer Res (1990) 1.16
Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance. Cancer Res (1990) 1.15
Periodic ZnO nanorod arrays defined by polystyrene microsphere self-assembled monolayers. Nano Lett (2006) 1.14
Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. Nucleic Acids Res (1979) 1.13
Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2. Proc Natl Acad Sci U S A (1988) 1.11
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. Biochemistry (1999) 1.10
Inversion/dimerization of plasmids mediated by inverted repeats. J Mol Biol (1999) 1.10
DNA looping alters local DNA conformation during transcription. J Mol Biol (1991) 1.08
Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Nucleic Acids Res (1999) 1.07
A model for tumor cell killing by topoisomerase poisons. Cancer Cells (1990) 1.05
In vitro functional characterization of bacterially expressed human fibroblast tropomyosin isoforms and their chimeric mutants. Cell Motil Cytoskeleton (1993) 1.05
Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis. J Biol Chem (2001) 1.04
Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne. Cancer Res (1996) 1.03
Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins. Nucleic Acids Res (1983) 1.03
Topoisomerase II levels during granulocytic maturation in vitro and in vivo. Cancer Res (1991) 0.97
Atp-bound topoisomerase ii as a target for antitumor drugs. J Biol Chem (2001) 0.94
Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas. Cancer Res (1987) 0.93
Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res (1997) 0.93
Differentially and developmentally regulated expression of three rice sucrose synthase genes. Plant Cell Physiol (1999) 0.93
HeLa toposiomerase I. Methods Enzymol (1983) 0.92
Tyr115, gln165 and trp209 contribute to the 1, 2-epoxy-3-(p-nitrophenoxy)propane-conjugating activity of glutathione S-transferase cGSTM1-1. J Mol Biol (2000) 0.92
A protein factor from Xenopus oocytes with simian virus 40 large tumor antigen-like DNA supercoiling activity. Proc Natl Acad Sci U S A (1990) 0.92
A replicational model for DNA recombination between direct repeats. J Mol Biol (1996) 0.91
Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs. Mol Pharmacol (1989) 0.90
Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. Biochem Pharmacol (1997) 0.90
Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. Eur J Biochem (1996) 0.89
Ubiquitin, SUMO-1, and UCRP in camptothecin sensitivity and resistance. Ann N Y Acad Sci (2000) 0.89