Published in J Biol Chem on January 25, 1978
Energy coupling in DNA gyrase and the mechanism of action of novobiocin. Proc Natl Acad Sci U S A (1978) 6.33
O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus. Proc Natl Acad Sci U S A (1978) 4.68
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54
DNA gyrase: affinity chromatography on novobiocin-Sepharose and catalytic properties. Nucleic Acids Res (1981) 4.16
Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc Natl Acad Sci U S A (1981) 3.98
Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site. Nucleic Acids Res (1985) 2.58
Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast. Proc Natl Acad Sci U S A (1995) 2.56
Association of the virD2 protein with the 5' end of T strands in Agrobacterium tumefaciens. J Bacteriol (1988) 2.44
Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. Nucleic Acids Res (1981) 2.39
Reverse gyrase: a helicase-like domain and a type I topoisomerase in the same polypeptide. Proc Natl Acad Sci U S A (1993) 2.04
Genome-linked protein associated with the 5' termini of bacteriophage phi29 DNA. J Virol (1978) 1.92
Covalent association of protein with replicative form DNA of parvovirus H-1. Proc Natl Acad Sci U S A (1979) 1.92
Identification and localization of a gene that specifies production of Escherichia coli DNA topoisomerase I. Proc Natl Acad Sci U S A (1981) 1.89
Identification of a vaccinia virus gene encoding a type I DNA topoisomerase. Proc Natl Acad Sci U S A (1987) 1.80
Two juxtaposed tyrosyl-OH groups participate in phi X174 gene A protein catalysed cleavage and ligation of DNA. Nucleic Acids Res (1986) 1.74
DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate. Proc Natl Acad Sci U S A (1981) 1.62
The F plasmid origin of transfer: DNA sequence of wild-type and mutant origins and location of origin-specific nicks. EMBO J (1984) 1.54
Escherichia coli DNA topoisomerase I catalyzed linking of single-stranded rings of complementary base sequences. Nucleic Acids Res (1978) 1.46
Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I. Proc Natl Acad Sci U S A (1989) 1.45
Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli. Proc Natl Acad Sci U S A (1987) 1.41
Identification of gene products programmed by restriction endonuclease DNA fragments using an E. coli in vitro system. Nucleic Acids Res (1981) 1.40
Effects of ATP and inhibitory factors on the activity of vaccinia virus type I topoisomerase. J Virol (1984) 1.34
Biochemical characterization of topoisomerase I purified from avian erythrocytes. Nucleic Acids Res (1983) 1.23
Inhibition of Micrococcus luteus DNA topoisomerase I by UV photoproducts. Proc Natl Acad Sci U S A (1983) 1.17
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity. J Biol Chem (2005) 1.17
Cloning of the gene topA encoding for DNA topoisomerase I and the physical mapping of the cysB-topA-trp region of Escherichia coli. Nucleic Acids Res (1983) 1.14
Genetic recombination of bacterial plasmid DNA: electron microscopic analysis of in vitro intramolecular recombination. Proc Natl Acad Sci U S A (1980) 1.12
Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex. Nucleic Acids Res (1980) 1.10
Reverse gyrase binding to DNA alters the double helix structure and produces single-strand cleavage in the absence of ATP. EMBO J (1989) 1.08
Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli. J Mol Biol (2008) 1.07
Drosophila topoisomerase I: isolation, purification and characterization. Nucleic Acids Res (1982) 1.05
Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region. Nucleic Acids Res (2008) 1.05
Eukaryotic DNA topoisomerase I reaction is topology dependent. Nucleic Acids Res (1988) 1.03
The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I. BMC Biochem (2002) 1.02
Enrichment and depletion of Hela topoisomerase I recognition sites among specific types of DNA elements. Nucleic Acids Res (1988) 0.96
Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I. Nucleic Acids Res (2007) 0.96
Inhibition of HeLa cell DNA topoisomerase I by ATP and phosphate. Nucleic Acids Res (1985) 0.95
Salmonella typhimurium mutants with reduced levels of transfer ribonucleic acid-inhibitable endodeoxyribonucleolytic activity. J Bacteriol (1980) 0.94
Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I. Nucleic Acids Res (2006) 0.93
Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery. Antimicrob Agents Chemother (1992) 0.92
Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I. Antimicrob Agents Chemother (1987) 0.89
Isolation and characterization of a gene encoding DNA topoisomerase I in Drosophila melanogaster. Nucleic Acids Res (1992) 0.89
The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining. J Biol Chem (2011) 0.87
Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. Pharmacogn Rev (2010) 0.87
Archaebacterial reverse gyrase cleavage-site specificity is similar to that of eubacterial DNA topoisomerases I. Nucleic Acids Res (1990) 0.87
Mechanistic study of E. coli DNA topoisomerase I: cleavage of oligonucleotides. Nucleic Acids Res (1983) 0.84
Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase. Nucleic Acids Res (1990) 0.84
A rapid procedure to purify Escherichia coli DNA topoisomerase I. Protein Expr Purif (2011) 0.84
Adenovirus infection elevates levels of cellular topoisomerase I. Proc Natl Acad Sci U S A (1985) 0.83
Incomplete reversion of double stranded DNA cleavage mediated by Drosophila topoisomerase II: formation of single stranded DNA cleavage complex in the presence of an anti-tumor drug VM26. Nucleic Acids Res (1992) 0.83
Determination of the recognition sequence of Mycobacterium smegmatis topoisomerase I on mycobacterial genomic sequences. Nucleic Acids Res (2000) 0.82
DNA topoisomerase from Agrobacterium tumefaciens: purification and catalytic properties. Nucleic Acids Res (1981) 0.75
ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism. Nucleic Acids Res (2010) 0.75
Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex. Sci Rep (2015) 0.75
Identification of proximal sites for unwound DNA substrate in E. coli topoisomerase I with oxidative crosslinking. FEBS Lett (2016) 0.75
Supercoiling of the DNA template during transcription. Proc Natl Acad Sci U S A (1987) 14.25
DNA topoisomerases. Annu Rev Biochem (1985) 13.01
Interaction between DNA and an Escherichia coli protein omega. J Mol Biol (1971) 11.03
Conformational fluctuations of DNA helix. Proc Natl Acad Sci U S A (1975) 8.72
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60
DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08
Helical repeat of DNA in solution. Proc Natl Acad Sci U S A (1979) 5.90
Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73
Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition. Proc Natl Acad Sci U S A (1981) 5.60
The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline cesium chloride density gradients. J Mol Biol (1974) 5.44
Sequence dependence of the helical repeat of DNA in solution. Nature (1981) 5.21
Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71
Mapping the active site tyrosine of Escherichia coli DNA gyrase. J Biol Chem (1987) 4.68
Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase. J Mol Biol (1987) 4.66
Structure and mechanism of DNA topoisomerase II. Nature (1996) 4.56
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52
Variation of the average rotation angle of the DNA helix and the superhelical turns of covalently closed cyclic lambda DNA. J Mol Biol (1969) 4.48
Interactions between twisted DNAs and enzymes: the effects of superhelical turns. J Mol Biol (1974) 4.43
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med (1996) 4.42
Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling. Proc Natl Acad Sci U S A (1982) 4.35
Thermodynamic properties of superhelical DNAs. Biochemistry (1975) 4.20
Torsional rigidity of DNA and length dependence of the free energy of DNA supercoiling. J Mol Biol (1984) 4.03
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res (1989) 4.01
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98
Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc Natl Acad Sci U S A (1981) 3.98
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A (1997) 3.84
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell (1980) 3.83
On the probability of ring closure of lambda DNA. J Mol Biol (1966) 3.82
Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding. Cell (1982) 3.80
Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA. J Mol Biol (1966) 3.76
Energetics of B-to-Z transition in DNA. Proc Natl Acad Sci U S A (1983) 3.66
Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA. J Biol Chem (1980) 3.31
DNA supercoiling and its effects on DNA structure and function. Cold Spring Harb Symp Quant Biol (1983) 3.29
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res (1988) 3.26
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
DNA topoisomerases: essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol (1994) 3.18
DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc Natl Acad Sci U S A (1988) 3.10
A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem (1981) 3.07
Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05
Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies. Cell (1989) 3.00
Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol (2001) 2.97
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A (1984) 2.84
Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Cell (1984) 2.80
T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature (1979) 2.76
Angular alteration of the DNA helix by E. coli RNA polymerase. Nat New Biol (1972) 2.75
Supercoiling of intracellular DNA can occur in eukaryotic cells. Cell (1988) 2.69
Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions. Cell (1983) 2.69
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome. Proc Natl Acad Sci U S A (1984) 2.69
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae. J Mol Biol (1999) 2.66
Recent studies of DNA topoisomerases. Biochim Biophys Acta (1987) 2.65
Topoisomerase I interacts with transcribed regions in Drosophila cells. Cell (1986) 2.65
DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme. Cell (1978) 2.60
Deoxyribonucleic acid gyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an alpha 2 beta 2 protein core. Biochemistry (1980) 2.59
On the sequence determinants and flexibility of the kinetoplast DNA fragment with abnormal gel electrophoretic mobilities. J Mol Biol (1985) 2.57
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res (1990) 2.49
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature (1994) 2.48
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases. Cell (1992) 2.48
Knotting of a DNA chain during ring closure. Science (1993) 2.45
Use of light for footprinting DNA in vivo. Nature (1984) 2.42
Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loop. J Mol Biol (1985) 2.42
Mapping of single-stranded regions in duplex DNA at the sequence level: single-strand-specific cytosine methylation in RNA polymerase-promoter complexes. Proc Natl Acad Sci U S A (1983) 2.41
Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. Nucleic Acids Res (1981) 2.39
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings. Cell (1989) 2.37
Mapping the topography of DNA wrapped around gyrase by nucleolytic and chemical probing of complexes of unique DNA sequences. Cell (1981) 2.36
Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J Biol Chem (1989) 2.33
Integration of the DNA of filamentous bacteriophage Cflt into the chromosomal DNA of its host. J Virol (1987) 2.31
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. Biochim Biophys Acta (1975) 2.25
Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc Natl Acad Sci U S A (1985) 2.21
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem (1996) 2.20
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. J Biol Chem (1998) 2.20
Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science (1978) 2.20
DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA. CRC Crit Rev Biochem (1983) 2.20
Interaction between yeast sgs1 helicase and DNA topoisomerase III. J Biol Chem (2000) 2.19
DNA topoisomerase IIbeta and neural development. Science (2000) 2.14
Effect of circularity and superhelicity on transcription from bacteriophagelambda DNA. Proc Natl Acad Sci U S A (1973) 2.13
An omega protein from Drosophila melanogaster. Biochemistry (1974) 2.12
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science (1989) 2.11
Yeast DNA topoisomerase II. An ATP-dependent type II topoisomerase that catalyzes the catenation, decatenation, unknotting, and relaxation of double-stranded DNA rings. J Biol Chem (1982) 2.09
Role of Bacillus subtilis SpoIIIE in DNA transport across the mother cell-prespore division septum. Science (2000) 2.08
Degree of superhelicity of covalently closed cyclic DNA's from Escherichia coli. J Mol Biol (1969) 2.08
Physiochemical studies on interactions between DNA and RNA polymerase. Unwinding of the DNA helix by Escherichia coli RNA polymerase. Nucleic Acids Res (1977) 2.07
Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. J Mol Biol (1976) 2.05
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol Psychiatry (2011) 2.05
Purification and characterization of a type II DNA topoisomerase from bovine calf thymus. J Biol Chem (1985) 2.04
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism. Cell (1994) 2.04
Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med (1997) 2.03
Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence. Cell (1985) 2.00
Measurements of unwinding of lac operator by repressor. Nature (1974) 1.98