Published in Annu Rev Pharmacol Toxicol on January 01, 2001
Homologous recombination in DNA repair and DNA damage tolerance. Cell Res (2008) 3.86
The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A (2002) 3.71
DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition. Chem Rev (2009) 2.65
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature (2009) 2.33
Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc Natl Acad Sci U S A (2002) 2.00
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A (2007) 1.92
Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. Cell Cycle (2011) 1.87
Quinolones: action and resistance updated. Curr Top Med Chem (2009) 1.73
Transcriptional consequences of topoisomerase inhibition. Mol Cell Biol (2001) 1.55
Human DNA topoisomerase I: relaxation, roles, and damage control. Chromosoma (2005) 1.51
Discovery of cellular regulation by protein degradation. J Biol Chem (2008) 1.48
An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene (2005) 1.47
Transcription-dependent degradation of topoisomerase I-DNA covalent complexes. Mol Cell Biol (2003) 1.43
A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes. J Biol Chem (2008) 1.31
Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response. J Biol Chem (2009) 1.31
Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage. Nucleic Acids Res (2005) 1.30
From bench to drug: human seizure modeling using Drosophila. Prog Neurobiol (2007) 1.24
Liver metastases from colorectal cancer: radioembolization with systemic therapy. Nat Rev Clin Oncol (2009) 1.24
Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination. Nucleic Acids Res (2004) 1.22
8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress. Free Radic Biol Med (2010) 1.20
ISG15 as a novel tumor biomarker for drug sensitivity. Mol Cancer Ther (2008) 1.19
The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway. Proc Natl Acad Sci U S A (2003) 1.18
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Res (2008) 1.17
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity. J Biol Chem (2005) 1.17
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol (2008) 1.15
Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res (2010) 1.14
Numerical analysis of etoposide induced DNA breaks. PLoS One (2009) 1.13
Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli. Mol Cell Biol (2006) 1.12
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry (2006) 1.12
Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks. J Biol Chem (2009) 1.11
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry (2007) 1.10
Noxa/Mcl-1 balance regulates susceptibility of cells to camptothecin-induced apoptosis. Neoplasia (2007) 1.09
Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair. Genetics (2007) 1.05
NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem (2008) 1.04
Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure. EMBO Rep (2005) 1.02
Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients. BMC Cancer (2008) 1.02
Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A (2003) 1.02
The binding orientation of a norindenoisoquinoline in the topoisomerase I-DNA cleavage complex is primarily governed by pi-pi stacking interactions. J Phys Chem B (2008) 1.02
An unusual type IB topoisomerase from African trypanosomes. Proc Natl Acad Sci U S A (2003) 1.01
Mouse spermatozoa contain a nuclease that is activated by pretreatment with EGTA and subsequent calcium incubation. J Cell Biochem (2008) 1.00
Topoisomerase assays. Curr Protoc Pharmacol (2012) 0.99
Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem Res Toxicol (2008) 0.99
RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression. Nucleic Acids Res (2011) 0.98
Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Oncogene (2006) 0.97
DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy. Neuroscience (2008) 0.95
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Mol Cell Biol (2005) 0.95
Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin. J Biol Chem (2007) 0.94
Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. Mol Cell Biol (2011) 0.93
Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxation. Nucleic Acids Res (2005) 0.93
Antibody-based screen for ionizing radiation-dependent changes in the Mammalian proteome for use in biodosimetry. Radiat Res (2009) 0.92
Single-molecule measurements of DNA topology and topoisomerases. J Biol Chem (2010) 0.92
Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. Nucleic Acids Res (2003) 0.92
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Res (2008) 0.92
Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. J Biol Chem (2011) 0.92
Distribution of gyrase and topoisomerase IV on bacterial nucleoid: implications for nucleoid organization. Nucleic Acids Res (2006) 0.91
Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid. Mol Biol Cell (2008) 0.91
The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes. Oncogene (2005) 0.91
Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence. Nucleic Acids Res (2008) 0.89
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol (2007) 0.89
TREX1 acts in degrading damaged DNA from drug-treated tumor cells. DNA Repair (Amst) (2009) 0.88
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. Biochemistry (2008) 0.88
Acidic pH induces topoisomerase II-mediated DNA damage. Proc Natl Acad Sci U S A (2003) 0.87
A G-quadruplex stabilizer induces M-phase cell cycle arrest. J Biol Chem (2009) 0.87
Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. Nucleic Acids Res (2006) 0.87
Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents. Bioorg Med Chem (2010) 0.87
Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia. Biologics (2008) 0.85
Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II. Invest New Drugs (2010) 0.84
Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response. J Biol Chem (2008) 0.84
Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents. J Med Chem (2014) 0.84
Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma. Bone Marrow Transplant (2009) 0.84
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem (2008) 0.83
Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II. Eur J Pharmacol (2008) 0.83
Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1. Nucleic Acids Res (2007) 0.83
Novel molecular markers of malignancy in histologically normal and benign breast. Patholog Res Int (2011) 0.82
Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites. Biochem J (2002) 0.82
Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents. Bioorg Med Chem (2011) 0.82
Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. Antimicrob Agents Chemother (2007) 0.82
Immunodetection of human topoisomerase I-DNA covalent complexes. Nucleic Acids Res (2016) 0.82
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. Bioorg Med Chem (2008) 0.82
A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma. Oncotarget (2012) 0.81
Inhibition of p53 by adenovirus type 12 E1B-55K deregulates cell cycle control and sensitizes tumor cells to genotoxic agents. J Virol (2011) 0.81
Double-stranded DNA breaks hidden in the neutral Comet assay suggest a role of the sperm nuclear matrix in DNA integrity maintenance. Mol Hum Reprod (2013) 0.81
'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani. Nucleic Acids Res (2006) 0.81
Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis. J Biol Chem (2013) 0.81
Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks. J Biol Chem (2008) 0.80
DNA-AP sites generation by etoposide in whole blood cells. BMC Cancer (2009) 0.80
Characterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase II. Nucleic Acids Res (2005) 0.79
FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance. Mol Cancer (2015) 0.79
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships. Bioorg Med Chem (2009) 0.79
Ultrasensitive isolation, identification and quantification of DNA-protein adducts by ELISA-based RADAR assay. Nucleic Acids Res (2014) 0.79
Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep (2016) 0.79
Targeting topoisomerase II with the chiral DNA-intercalating ruthenium(II) polypyridyl complexes. J Biol Inorg Chem (2007) 0.79
Topoisomerase II inhibition involves characteristic chromosomal expression patterns. BMC Genomics (2008) 0.78
Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives. PLoS One (2011) 0.77
Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters. PLoS One (2016) 0.77
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem (1985) 8.60
Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73
Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biol (1985) 5.00
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res (1989) 4.01
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98
Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc Natl Acad Sci U S A (1981) 3.98
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell (1980) 3.83
Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. J Biol Chem (1978) 3.35
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res (1988) 3.26
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
DNA topoisomerases: essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol (1994) 3.18
A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem (1981) 3.07
Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05
Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies. Cell (1989) 3.00
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc Natl Acad Sci U S A (1984) 2.84
T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature (1979) 2.76
DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme. Cell (1978) 2.60
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res (1990) 2.49
Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. Nucleic Acids Res (1981) 2.39
Integration of the DNA of filamentous bacteriophage Cflt into the chromosomal DNA of its host. J Virol (1987) 2.31
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. Biochim Biophys Acta (1975) 2.25
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem (1996) 2.20
DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA. CRC Crit Rev Biochem (1983) 2.20
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. Science (1989) 2.11
Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. J Mol Biol (1976) 2.05
Purification and characterization of a type II DNA topoisomerase from bovine calf thymus. J Biol Chem (1985) 2.04
Topoisomerase-targeting antitumor drugs. Biochim Biophys Acta (1989) 1.92
Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I. Proc Natl Acad Sci U S A (1995) 1.89
Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 1.88
Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. Cancer Res (1993) 1.88
Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA. Nucleic Acids Res (1982) 1.78
recA-independent and recA-dependent intramolecular plasmid recombination. Differential homology requirement and distance effect. J Mol Biol (1994) 1.72
Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. Proc Natl Acad Sci U S A (1988) 1.70
Intra- and intermolecular strand transfer by HeLa DNA topoisomerase I. J Biol Chem (1982) 1.67
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Cancer Res (2001) 1.63
Processing of topoisomerase I cleavable complexes into DNA damage by transcription. Nucleic Acids Res (1997) 1.63
Knotted DNA from bacteriophage capsids. Proc Natl Acad Sci U S A (1981) 1.59
In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin. Cell (1985) 1.57
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem (1997) 1.56
Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells. Cancer Res (1985) 1.53
In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin. Mol Cell Biol (1986) 1.52
26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J Biol Chem (2001) 1.50
Expression of alpha-amylases, carbohydrate metabolism, and autophagy in cultured rice cells is coordinately regulated by sugar nutrient. Plant J (1994) 1.49
SUMO-1 conjugation to human DNA topoisomerase II isozymes. J Biol Chem (2000) 1.48
Metabolic derepression of alpha-amylase gene expression in suspension-cultured cells of rice. J Biol Chem (1991) 1.48
SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage. Proc Natl Acad Sci U S A (2000) 1.47
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B. Cancer Res (1992) 1.42
Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives. J Med Chem (1993) 1.41
Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. Cancer Res (1988) 1.41
Interaction between DNA and Escherichia coli DNA topoisomerase I. Formation of complexes between the protein and superhelical and nonsuperhelical duplex DNAs. J Biol Chem (1979) 1.41
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res (1989) 1.40
DNA topoisomerases as anticancer drug targets. Adv Pharmacol (1990) 1.38
Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor. EMBO J (1991) 1.34
DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II. Cancer Res (1986) 1.33
DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. Cancer Res (1989) 1.31
Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells. Nature (1986) 1.31
Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons. J Biol Chem (1989) 1.31
Identification of the breakage-reunion subunit of T4 DNA topoisomerase. J Biol Chem (1984) 1.31
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors. Proc Natl Acad Sci U S A (1993) 1.30
DNA rearrangement mediated by inverted repeats. Proc Natl Acad Sci U S A (1996) 1.30
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry (2001) 1.29
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. Genes Dev (1999) 1.25
Template supercoiling during ATP-dependent DNA helix tracking: studies with simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A (1989) 1.21
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. Cancer Res (1991) 1.20
Sugars act as signal molecules and osmotica to regulate the expression of alpha-amylase genes and metabolic activities in germinating cereal grains. Plant Mol Biol (1996) 1.19
ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB. Proc Natl Acad Sci U S A (1991) 1.18
A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures. Cancer Res (1993) 1.17
Hypernegative supercoiling of the DNA template during transcription elongation in vitro. J Biol Chem (1994) 1.16
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res (1988) 1.16
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. Cancer Res (1990) 1.16
Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance. Cancer Res (1990) 1.15
Periodic ZnO nanorod arrays defined by polystyrene microsphere self-assembled monolayers. Nano Lett (2006) 1.14
Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. Nucleic Acids Res (1979) 1.13
Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2. Proc Natl Acad Sci U S A (1988) 1.11
Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. Biochemistry (1999) 1.10
Inversion/dimerization of plasmids mediated by inverted repeats. J Mol Biol (1999) 1.10
DNA looping alters local DNA conformation during transcription. J Mol Biol (1991) 1.08
Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. Nucleic Acids Res (1999) 1.07
In vitro functional characterization of bacterially expressed human fibroblast tropomyosin isoforms and their chimeric mutants. Cell Motil Cytoskeleton (1993) 1.05
A model for tumor cell killing by topoisomerase poisons. Cancer Cells (1990) 1.05
Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis. J Biol Chem (2001) 1.04
Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins. Nucleic Acids Res (1983) 1.03
Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne. Cancer Res (1996) 1.03
Topoisomerase II levels during granulocytic maturation in vitro and in vivo. Cancer Res (1991) 0.97
Atp-bound topoisomerase ii as a target for antitumor drugs. J Biol Chem (2001) 0.94
Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas. Cancer Res (1987) 0.93
Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. Cancer Res (1997) 0.93
Differentially and developmentally regulated expression of three rice sucrose synthase genes. Plant Cell Physiol (1999) 0.93
HeLa toposiomerase I. Methods Enzymol (1983) 0.92
Tyr115, gln165 and trp209 contribute to the 1, 2-epoxy-3-(p-nitrophenoxy)propane-conjugating activity of glutathione S-transferase cGSTM1-1. J Mol Biol (2000) 0.92
A protein factor from Xenopus oocytes with simian virus 40 large tumor antigen-like DNA supercoiling activity. Proc Natl Acad Sci U S A (1990) 0.92
A replicational model for DNA recombination between direct repeats. J Mol Biol (1996) 0.91
Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs. Mol Pharmacol (1989) 0.90
Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. Biochem Pharmacol (1997) 0.90
Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. Eur J Biochem (1996) 0.89
Ubiquitin, SUMO-1, and UCRP in camptothecin sensitivity and resistance. Ann N Y Acad Sci (2000) 0.89