Published in Science on December 21, 2006
Germinal-center organization and cellular dynamics. Immunity (2007) 5.62
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49
Follicular helper T cells: lineage and location. Immunity (2009) 4.75
From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer (2009) 4.15
Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol (2007) 3.63
Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol Rev (2009) 3.56
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol (2010) 3.51
The who, how and where of antigen presentation to B cells. Nat Rev Immunol (2009) 3.12
Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity (2009) 2.98
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell (2012) 2.98
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol (2008) 2.86
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol (2010) 2.85
Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol (2009) 2.82
Molecular programming of B cell memory. Nat Rev Immunol (2011) 2.73
Control systems and decision making for antibody production. Nat Immunol (2010) 2.60
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol (2009) 2.49
Development and migration of plasma cells in the mouse lymph node. Immunity (2010) 2.44
Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood (2012) 2.30
Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol (2008) 2.20
Clonal selection in the germinal centre by regulated proliferation and hypermutation. Nature (2014) 2.16
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J Exp Med (2009) 2.12
Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nat Med (2009) 2.03
A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med (2011) 1.97
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat Immunol (2008) 1.96
A decade of imaging cellular motility and interaction dynamics in the immune system. Science (2012) 1.94
New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol (2009) 1.92
Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med (2009) 1.91
Class-switched memory B cells remodel BCRs within secondary germinal centers. Nat Immunol (2015) 1.90
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol (2012) 1.90
Genetic analysis of basophil function in vivo. Nat Immunol (2011) 1.82
T follicular helper cell dynamics in germinal centers. Science (2013) 1.80
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells. Immunity (2016) 1.79
Follicular helper T cells as cognate regulators of B cell immunity. Curr Opin Immunol (2009) 1.77
B cell follicles and antigen encounters of the third kind. Nat Immunol (2010) 1.76
Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol (2010) 1.73
Signals that influence T follicular helper cell differentiation and function. Semin Immunopathol (2010) 1.62
Dynamics of B cells in germinal centres. Nat Rev Immunol (2015) 1.61
A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis. PLoS Pathog (2014) 1.58
A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice. J Virol (2009) 1.56
In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J Immunol (2010) 1.54
Analysing immune cell migration. Nat Rev Immunol (2009) 1.52
Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science (2014) 1.51
Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J Immunol (2009) 1.49
Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. Immunity (2009) 1.49
Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci U S A (2010) 1.48
B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. Curr Opin Hematol (2008) 1.47
Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med (2008) 1.44
Plasma cells negatively regulate the follicular helper T cell program. Nat Immunol (2010) 1.42
In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo. Nat Commun (2011) 1.41
CD40L is transferred to antigen-presenting B cells during delivery of T-cell help. Eur J Immunol (2016) 1.40
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature (2012) 1.39
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol (2011) 1.39
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα. Nat Immunol (2012) 1.34
Germinal center reutilization by newly activated B cells. J Exp Med (2009) 1.34
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J Exp Med (2013) 1.33
Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity (2013) 1.27
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies. Cell (2015) 1.27
Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci U S A (2012) 1.26
Adjuvant-specific regulation of long-term antibody responses by ZBTB20. J Exp Med (2014) 1.25
Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice. J Exp Med (2010) 1.25
Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS One (2012) 1.24
Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol Cell Biol (2010) 1.24
CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci (2012) 1.24
T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature (2014) 1.23
Regulation of AID, the B-cell genome mutator. Genes Dev (2013) 1.21
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination. Crit Rev Immunol (2007) 1.19
From seeing to believing: labelling strategies for in vivo cell-tracking experiments. Interface Focus (2013) 1.17
Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy. Proc Natl Acad Sci U S A (2009) 1.14
Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells. Proc Natl Acad Sci U S A (2011) 1.14
Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs. Blood (2010) 1.10
Germinal centers in human lymph nodes contain reactivated memory B cells. J Exp Med (2007) 1.09
AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans. PLoS Pathog (2012) 1.07
TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones. J Exp Med (2009) 1.04
Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells. Blood (2008) 1.04
The microanatomy of B cell activation. Curr Opin Immunol (2009) 1.04
Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med (2014) 1.04
Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Immunity (2012) 1.02
CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol (2012) 1.02
Visualizing antibody affinity maturation in germinal centers. Science (2016) 1.01
Functional immunoimaging: the revolution continues. Nat Rev Immunol (2012) 1.01
Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes. Vaccine (2012) 1.01
Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas. Leuk Lymphoma (2008) 1.00
Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. J Exp Med (2012) 1.00
B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci U S A (2011) 1.00
IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol (2013) 0.99
The LRF transcription factor regulates mature B cell development and the germinal center response in mice. J Clin Invest (2011) 0.99
Towards estimating the true duration of dendritic cell interactions with T cells. J Immunol Methods (2009) 0.98
HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway. Blood (2010) 0.97
HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells. Science (2015) 0.97
Regulated selection of germinal-center cells into the memory B cell compartment. Nat Immunol (2016) 0.97
EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature (2016) 0.96
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol (2011) 0.94
Modular design of immunological synapses and kinapses. Cold Spring Harb Perspect Biol (2009) 0.94
Optimality of mutation and selection in germinal centers. PLoS Comput Biol (2010) 0.93
S1PR2 links germinal center confinement and growth regulation. Immunol Rev (2012) 0.93
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 7.17
Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04
Germinal-center organization and cellular dynamics. Immunity (2007) 5.62
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science (2005) 5.50
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol (2007) 5.22
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol (2007) 5.14
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol (2007) 4.46
Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol (2007) 4.42
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol (2004) 4.22
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity (2004) 4.00
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol (2004) 3.65
Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol (2007) 3.63
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 3.41
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature (2002) 3.35
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity (2007) 3.05
Integrin-mediated long-term B cell retention in the splenic marginal zone. Science (2002) 3.00
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity (2005) 2.97
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant (2004) 2.70
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68
CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity (2002) 2.67
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity (2011) 2.60
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med (2005) 2.57
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol (2002) 2.55
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol (2009) 2.49
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
EBI2 mediates B cell segregation between the outer and centre follicle. Nature (2009) 2.20
Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol (2008) 2.20
Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med (2003) 2.16
Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis. J Immunol (2011) 2.16
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest (2013) 2.04
How T cells earn the follicular rite of passage. Immunity (2011) 2.03
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol (2009) 1.96
Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat Immunol (2008) 1.96
CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol (2007) 1.91
Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med (2009) 1.91
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest (2010) 1.83
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol (2004) 1.81
Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol (2011) 1.77
Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol (2010) 1.73
Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes. J Exp Med (2002) 1.73
CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. J Biol Chem (2010) 1.69
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science (2010) 1.68
CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol (2004) 1.67
B cell migration and interactions in the early phase of antibody responses. Curr Opin Immunol (2006) 1.62
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58
Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med (2003) 1.57
Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci U S A (2010) 1.56
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med (2005) 1.52
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med (2006) 1.51
DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol (2011) 1.46
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion. Clin Immunol (2008) 1.46
Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity (2012) 1.44
Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J Exp Med (2011) 1.44
Deficiency in IL-17-committed Vγ4(+) γδ T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat Immunol (2013) 1.43
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science (2011) 1.40
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature (2012) 1.39
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol (2011) 1.39
Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med (2003) 1.38
Lymph node macrophages. J Innate Immun (2012) 1.36
Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity (2013) 1.27
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc Natl Acad Sci U S A (2006) 1.25
Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS One (2012) 1.24
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J Exp Med (2011) 1.22
Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol (2004) 1.22
Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am J Pathol (2011) 1.21
BANK negatively regulates Akt activation and subsequent B cell responses. Immunity (2006) 1.21
A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS One (2010) 1.20
A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A (2008) 1.19
Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells. J Immunol (2004) 1.13
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci (2012) 1.05
The microanatomy of B cell activation. Curr Opin Immunol (2009) 1.04
EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife (2013) 1.03
CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood (2013) 1.02
Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Blood (2009) 1.00
B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci U S A (2011) 1.00
Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Am J Pathol (2004) 0.99
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. J Physiol (2005) 0.99
CXCR4 promotes B cell egress from Peyer's patches. J Exp Med (2013) 0.99
EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol (2011) 0.95
FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. J Immunol (2011) 0.93
S1PR2 links germinal center confinement and growth regulation. Immunol Rev (2012) 0.93
Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells. Blood (2010) 0.93
Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies. Elife (2013) 0.90
Tetrahydroquinoline derivatives as CRTH2 antagonists. Bioorg Med Chem Lett (2009) 0.84
Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. Curr Top Microbiol Immunol (2014) 0.83