Published in Cell on February 12, 2015
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell (2016) 2.27
The MAGE protein family and cancer. Curr Opin Cell Biol (2015) 1.00
Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies. Mol Cancer Res (2015) 0.97
Advances in Autophagy Regulatory Mechanisms. Cells (2016) 0.90
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J (2016) 0.87
Molecular Pathways: Is AMPK a Friend or a Foe in Cancer? Clin Cancer Res (2015) 0.87
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J Cell Biol (2015) 0.86
AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy (2016) 0.81
Regulation and function of AMPK in physiology and diseases. Exp Mol Med (2016) 0.80
Gene and miRNA expression changes in squamous cell carcinoma of larynx and hypopharynx. Genes Cancer (2015) 0.80
Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types. Nat Commun (2016) 0.80
Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding. PLoS One (2016) 0.79
mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK. Oncotarget (2016) 0.78
Targeting LKB1 in cancer - exposing and exploiting vulnerabilities. Br J Cancer (2015) 0.78
BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma. Oncotarget (2016) 0.78
Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1. PLoS One (2016) 0.78
Expression of Phosphorylated AMP-Activated Protein Kinase Predicts Response to Transarterial Chemoembolization in Postoperative Cases of Hepatocellular Carcinoma. Medicine (Baltimore) (2016) 0.77
Functional annotation of rare gene aberration drivers of pancreatic cancer. Nat Commun (2016) 0.77
SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling. Nat Commun (2015) 0.77
Deubiquitination and Activation of AMPK by USP10. Mol Cell (2016) 0.77
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Mol Cell (2017) 0.76
Hypothalamic AMPK as a Regulator of Energy Homeostasis. Neural Plast (2016) 0.76
AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms. Transl Oncol (2016) 0.75
The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Sci Rep (2016) 0.75
Cancer cells activate damage-tolerant and error-prone DNA synthesis. Mol Cell Oncol (2016) 0.75
Expression and prognostic relevance of MAGE-A3 and MAGE-C2 in non-small cell lung cancer. Oncol Lett (2017) 0.75
MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation. Oncogenesis (2017) 0.75
AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget (2016) 0.75
Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator. Oncoimmunology (2016) 0.75
Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells. Oncol Lett (2016) 0.75
TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci (2016) 0.75
A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases. J Mol Biol (2017) 0.75
Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation. Mol Cell Endocrinol (2016) 0.75
The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling. Oncogene (2016) 0.75
Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK. Curr Biol (2015) 0.75
A quantitative transcriptomic analysis of the physiological significance of mTOR signaling in goat fetal fibroblasts. BMC Genomics (2016) 0.75
Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer. Stem Cells Int (2017) 0.75
Spontaneous CD4(+) and CD8(+) T cell responses directed against cancer testis antigens are present in the peripheral blood of testicular cancer patients. Eur J Immunol (2017) 0.75
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science (2002) 14.20
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Comprehensive molecular profiling of lung adenocarcinoma. Nature (2014) 11.02
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer (2005) 9.46
Autophagy in human health and disease. N Engl J Med (2013) 8.71
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 8.43
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 7.15
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22
Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer (2012) 6.14
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab (2006) 4.64
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol (1985) (2000) 3.37
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem (2006) 3.31
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell (2010) 3.28
An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res (2001) 3.08
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett (1987) 3.04
Structure, chromosomal localization, and expression of 12 genes of the MAGE family. Immunogenetics (1994) 2.93
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun (2001) 2.86
Metformin--mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol (2014) 2.68
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell (2013) 2.66
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell (2013) 2.63
Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene (2007) 2.27
Somatic LKB1 mutations promote cervical cancer progression. PLoS One (2009) 2.21
MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. Cancer Res (2007) 2.08
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A (2009) 2.08
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. PLoS One (2009) 2.03
AMP-activated protein kinase: a target for drugs both ancient and modern. Chem Biol (2012) 2.00
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat (2011) 1.90
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine. Cancer Res (1994) 1.86
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J (2005) 1.85
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. Proc Natl Acad Sci U S A (2006) 1.82
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci (2002) 1.79
LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol (2013) 1.73
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology (2009) 1.72
Repositioning metformin for cancer prevention and treatment. Trends Endocrinol Metab (2013) 1.68
Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Res Treat (2012) 1.66
The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. Cancer Res (2008) 1.53
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res (2012) 1.52
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J (2008) 1.38
Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer (2009) 1.38
Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res (2013) 1.32
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell (2013) 1.32
Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin. Cancer Res (2010) 1.27
Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis. Cancer Res (2001) 1.24
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse. Development (2002) 1.06
AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Res (2014) 1.04
When MAGE meets RING: insights into biological functions of MAGE proteins. Protein Cell (2011) 1.00
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (2013) 0.91
Metabolism of round spermatids: evidence that lactate is preferred substrate. Am J Physiol (1984) 0.90
MAGE-A3 is highly expressed in a subset of colorectal cancer patients. Cancer Immun (2012) 0.83
5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors. J Biol Chem (2014) 0.81