Published in Nat Struct Mol Biol on March 09, 2015
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Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells. Curr Opin Hematol (2015) 0.87
The Aging Epigenome. Mol Cell (2016) 0.84
Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet (2016) 0.83
Coupling circadian rhythms of metabolism and chromatin remodelling. Diabetes Obes Metab (2015) 0.81
Methylation gets into rhythm with NAD(+)-SIRT1. Nat Struct Mol Biol (2015) 0.79
Sirtuin-dependent clock control: new advances in metabolism, aging and cancer. Curr Opin Clin Nutr Metab Care (2015) 0.79
Dynamic chromatin regulation at Notch target genes. Transcription (2016) 0.78
Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species. Proc Natl Acad Sci U S A (2016) 0.76
Histone Deacetylase SIRT1 Controls Proliferation, Circadian Rhythm, and Lipid Metabolism during Liver Regeneration in Mice. J Biol Chem (2016) 0.75
Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan. Front Genet (2016) 0.75
Life in a dark biosphere: a review of circadian physiology in "arrhythmic" environments. J Comp Physiol B (2016) 0.75
Systems Biology-Derived Discoveries of Intrinsic Clocks. Front Neurol (2017) 0.75
Yin-yang actions of histone methylation regulatory complexes in the brain. Epigenomics (2016) 0.75
The Circadian NAD(+) Metabolism: Impact on Chromatin Remodeling and Aging. Biomed Res Int (2016) 0.75
Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection. Front Endocrinol (Lausanne) (2017) 0.75
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
The complex language of chromatin regulation during transcription. Nature (2007) 16.97
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature (1996) 10.81
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Posttranslational mechanisms regulate the mammalian circadian clock. Cell (2001) 7.93
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
Altered Hox expression and segmental identity in Mll-mutant mice. Nature (1995) 6.60
Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science (2000) 6.55
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell (2013) 4.85
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science (2012) 4.77
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature (2007) 2.76
CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature (2007) 2.65
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol (2001) 2.58
Metabolic regulation of epigenetics. Cell Metab (2012) 2.55
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell (2010) 2.25
NAD+ and sirtuins in aging and disease. Trends Cell Biol (2014) 2.07
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol (2010) 2.00
H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell (2013) 2.00
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
Clocks, metabolism, and the epigenome. Mol Cell (2012) 1.84
MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proc Natl Acad Sci U S A (2003) 1.83
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J Biol Chem (2002) 1.80
Connecting threads: epigenetics and metabolism. Cell (2012) 1.75
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell (2014) 1.68
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell (2014) 1.26
CK2alpha phosphorylates BMAL1 to regulate the mammalian clock. Nat Struct Mol Biol (2009) 1.23
Genome dynamics in aging mice. Genome Res (2002) 1.20
Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain. Brain Res (2010) 1.18
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15
CLOCK:BMAL1 is a pioneer-like transcription factor. Genes Dev (2014) 1.13
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A (2013) 1.00
Cycles in spatial and temporal chromosomal organization driven by the circadian clock. Nat Struct Mol Biol (2013) 0.96
Deviation of innate circadian period from 24 h reduces longevity in mice. Aging Cell (2012) 0.94
Sirtuins and the circadian clock: bridging chromatin and metabolism. Sci Signal (2014) 0.92
Regulation of an RNA granule during spermatogenesis: acetylation of MVH in the chromatoid body of germ cells. J Cell Sci (2012) 0.92
Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. Proc Natl Acad Sci U S A (2014) 0.85
Circadian clock: linking epigenetics to aging. Curr Opin Genet Dev (2014) 0.83
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