Published in Nature on December 13, 2007
The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal (2009) 3.19
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol (2010) 2.00
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
Clocks, metabolism, and the epigenome. Mol Cell (2012) 1.84
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol (2009) 1.80
Post-translational modifications in circadian rhythms. Trends Biochem Sci (2009) 1.80
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Genes Dev (2010) 1.57
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol (2015) 1.55
Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55
Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53
Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol (2008) 1.52
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One (2010) 1.44
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock. PLoS Biol (2015) 1.42
Plasticity and specificity of the circadian epigenome. Nat Neurosci (2010) 1.41
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Epigenetics and lifestyle. Epigenomics (2011) 1.34
Rev-erb-alpha: an integrator of circadian rhythms and metabolism. J Appl Physiol (1985) (2009) 1.34
KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chembiochem (2010) 1.32
Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab (2011) 1.32
Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription. Proc Natl Acad Sci U S A (2012) 1.28
Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem (2011) 1.27
bHLH-PAS proteins in cancer. Nat Rev Cancer (2013) 1.23
CK2alpha phosphorylates BMAL1 to regulate the mammalian clock. Nat Struct Mol Biol (2009) 1.23
High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chem Biol (2009) 1.21
Clock genes, intestinal transport and plasma lipid homeostasis. Trends Endocrinol Metab (2009) 1.21
Tuning the mammalian circadian clock: robust synergy of two loops. PLoS Comput Biol (2011) 1.18
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab (2013) 1.16
CHD1 remodels chromatin and influences transient DNA methylation at the clock gene frequency. PLoS Genet (2011) 1.16
SIRT1 is a circadian deacetylase for core clock components. Cell (2008) 1.15
Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging (Albany NY) (2010) 1.14
Circadian rhythms and mood regulation: insights from pre-clinical models. Eur Neuropsychopharmacol (2011) 1.13
Circadian rhythms and memory: not so simple as cogs and gears. EMBO Rep (2009) 1.12
Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A (2013) 1.11
Torpor induction in mammals: recent discoveries fueling new ideas. Trends Endocrinol Metab (2009) 1.10
Stoichiometric relationship among clock proteins determines robustness of circadian rhythms. J Biol Chem (2011) 1.09
The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci (2012) 1.08
Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex. PLoS One (2011) 1.07
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. Diabetes Metab J (2013) 1.05
Circadian regulation of ion channels and their functions. J Neurochem (2009) 1.02
A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J Biol Chem (2012) 1.02
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A (2013) 1.00
Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver. Mol Cell Biol (2010) 1.00
Circadian rhythm connections to oxidative stress: implications for human health. Antioxid Redox Signal (2013) 1.00
Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter. Nucleic Acids Res (2009) 0.99
Rhythmic expression of microRNA-26a regulates the L-type voltage-gated calcium channel alpha1C subunit in chicken cone photoreceptors. J Biol Chem (2009) 0.99
Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression. BMC Med (2013) 0.99
Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation. Aging (Albany NY) (2011) 0.98
The circadian epigenome: how metabolism talks to chromatin remodeling. Curr Opin Cell Biol (2013) 0.98
Unwinding the molecular basis of interval and circadian timing. Front Integr Neurosci (2011) 0.98
PML regulates PER2 nuclear localization and circadian function. EMBO J (2012) 0.98
Emerging models for the molecular basis of mammalian circadian timing. Biochemistry (2014) 0.98
A time to remember: the role of circadian clocks in learning and memory. Behav Neurosci (2014) 0.97
Joining the dots: from chromatin remodeling to neuronal plasticity. Curr Opin Neurobiol (2010) 0.97
The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann N Y Acad Sci (2012) 0.96
Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience (2013) 0.96
Cycles in spatial and temporal chromosomal organization driven by the circadian clock. Nat Struct Mol Biol (2013) 0.96
Circadian rhythm and its role in malignancy. J Circadian Rhythms (2010) 0.94
Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals. PLoS One (2008) 0.94
Circadian CLOCK-mediated regulation of target-tissue sensitivity to glucocorticoids: implications for cardiometabolic diseases. Endocr Dev (2010) 0.93
The epigenetic landscape of alcoholism. Int Rev Neurobiol (2014) 0.91
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci (2014) 0.91
Minireview: NAD+, a circadian metabolite with an epigenetic twist. Endocrinology (2011) 0.91
Effect of chronic ethanol exposure on the liver of Clock-mutant mice. J Circadian Rhythms (2009) 0.90
Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. J Biol Chem (2011) 0.90
Circadian rhythms in urinary functions: possible roles of circadian clocks? Int Neurourol J (2011) 0.89
Circadian clocks, epigenetics, and cancer. Curr Opin Oncol (2015) 0.89
Nuclear receptors rock around the clock. EMBO Rep (2014) 0.89
Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. J Biol Chem (2014) 0.89
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. Genes Dev (2012) 0.89
The circadian clock and cell cycle: interconnected biological circuits. Curr Opin Cell Biol (2013) 0.89
A central role for ubiquitination within a circadian clock protein modification code. Front Mol Neurosci (2014) 0.88
The role of circadian clocks in metabolic disease. Yale J Biol Med (2012) 0.87
Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol (2010) 0.87
Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci. Mol Cells (2012) 0.87
Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Mol Metab (2016) 0.87
Metabolic regulation of histone post-translational modifications. ACS Chem Biol (2015) 0.87
Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression. PLoS One (2011) 0.87
Oxidation-reduction cycles of peroxiredoxin proteins and nontranscriptional aspects of timekeeping. Biochemistry (2014) 0.86
Transcriptional control of antioxidant defense by the circadian clock. Antioxid Redox Signal (2014) 0.86
Working around the clock: circadian rhythms and skeletal muscle. J Appl Physiol (1985) (2009) 0.86
Clock genes: their role in colorectal cancer. World J Gastroenterol (2014) 0.86
Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. Proc Natl Acad Sci U S A (2014) 0.85
Clk post-transcriptional control denoises circadian transcription both temporally and spatially. Nat Commun (2015) 0.84
A potential role for CHH DNA methylation in cotton fiber growth patterns. PLoS One (2013) 0.84
The Molecular Circadian Clock and Alcohol-Induced Liver Injury. Biomolecules (2015) 0.84
The biological clock is regulated by adrenergic signaling in brown fat but is dispensable for cold-induced thermogenesis. PLoS One (2013) 0.83
Mammalian molecular clocks. Exp Neurobiol (2011) 0.83
Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol (2015) 0.83
Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet (2016) 0.83
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism. Genome Integr (2013) 0.82
The circadian control of skin and cutaneous photodamage. Photochem Photobiol (2012) 0.81
Circadian rhythms and memory formation: regulation by chromatin remodeling. Front Mol Neurosci (2012) 0.81
Coupling circadian rhythms of metabolism and chromatin remodelling. Diabetes Obes Metab (2015) 0.81
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell (2004) 5.27
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50
A web of circadian pacemakers. Cell (2002) 4.39
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A (2002) 3.03
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc Natl Acad Sci U S A (2006) 2.75
Chromatin remodelling and epigenetic features of germ cells. Nature (2005) 2.49
Circadian clock control by SUMOylation of BMAL1. Science (2005) 2.30
Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A (2012) 2.22
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
The chromatoid body: a germ-cell-specific RNA-processing centre. Nat Rev Mol Cell Biol (2007) 2.15
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol (2010) 2.00
Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol (2009) 1.99
Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Mol Biol (2004) 1.94
PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab (2010) 1.91
Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis. Nat Methods (2004) 1.91
RNA granules in germ cells. Cold Spring Harb Perspect Biol (2011) 1.80
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood (2008) 1.80
Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element. J Biol Chem (2005) 1.77
Connecting threads: epigenetics and metabolism. Cell (2012) 1.75
Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell (2002) 1.71
Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci (2003) 1.70
Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A (2013) 1.64
The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1. Proc Natl Acad Sci U S A (2003) 1.64
Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. Proc Natl Acad Sci U S A (2005) 1.59
Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55
Key role of Src kinase in S100B-induced activation of the receptor for advanced glycation end products in vascular smooth muscle cells. J Biol Chem (2006) 1.52
Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci (2006) 1.52
Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD. Mol Cell (2005) 1.51
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway. Cell Cycle (2012) 1.51
Riding tandem: circadian clocks and the cell cycle. Cell (2007) 1.49
Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM. Exp Cell Res (2002) 1.48
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One (2010) 1.44
Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells. Neuron (2007) 1.43
Plasticity and specificity of the circadian epigenome. Nat Neurosci (2010) 1.41
Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Development (2002) 1.37
Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism. Mol Cell Biol (2010) 1.35
Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol (2002) 1.34
Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1. Int J Biochem Cell Biol (2008) 1.33
Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A (2006) 1.32
Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab (2011) 1.32
Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts. Genes Cells (2003) 1.31
Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. FASEB J (2004) 1.30
The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. J Cell Sci (2003) 1.30
Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol Endocrinol (2006) 1.30
Signaling to the circadian clock: plasticity by chromatin remodeling. Curr Opin Cell Biol (2007) 1.30
Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases. Curr Biol (2002) 1.23
CK2alpha phosphorylates BMAL1 to regulate the mammalian clock. Nat Struct Mol Biol (2009) 1.23
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A (2010) 1.20
CREM-dependent transcription in male germ cells controlled by a kinesin. Science (2002) 1.20
Testis-specific transcription mechanisms promoting male germ-cell differentiation. Reproduction (2004) 1.16
Common pathways in circadian and cell cycle clocks: light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1. Proc Natl Acad Sci U S A (2005) 1.16
Circadian clock and breast cancer: a molecular link. Cell Cycle (2007) 1.14
DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation. Mol Endocrinol (2003) 1.14
Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress. J Neurosci (2005) 1.14
CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics. Nat Methods (2012) 1.14
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A (2006) 1.13
A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc Natl Acad Sci U S A (2002) 1.12
No circadian rhythms in testis: Period1 expression is clock independent and developmentally regulated in the mouse. Mol Endocrinol (2003) 1.12
Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. BMC Genomics (2010) 1.12
Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish. Proc Natl Acad Sci U S A (2007) 1.11
Structural and functional features of transcription factors controlling the circadian clock. Curr Opin Genet Dev (2005) 1.11
Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein. J Neurosci (2005) 1.11
Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A (2013) 1.11
Synchronization of circadian Per2 rhythms and HSF1-BMAL1:CLOCK interaction in mouse fibroblasts after short-term heat shock pulse. PLoS One (2011) 1.09
The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci (2012) 1.08
Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Mol Pharmacol (2011) 1.07
Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A (2013) 1.07
A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell (2004) 1.07
Hippocalcin, new Ca(2+) sensor of a ROS-GC subfamily member, ONE-GC, membrane guanylate cyclase transduction system. Mol Cell Biochem (2009) 1.06
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.05
The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Mol Cell Biol (2005) 1.04
Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev Biol (2008) 1.03
Environmental stimulus perception and control of circadian clocks. Curr Opin Neurobiol (2002) 1.02
Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis. J Biol Chem (2003) 1.01
Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility. Hum Fertil (Camb) (2006) 1.00
Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons. J Biol Rhythms (2007) 1.00
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A (2013) 1.00
Production of fertile offspring from genetically infertile male mice. Proc Natl Acad Sci U S A (2004) 0.99
Glutamate-induced assembly of bacterial cell division protein FtsZ. J Biol Chem (2002) 0.98
Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation. Aging (Albany NY) (2011) 0.98
Negative control of circadian clock regulator E4BP4 by casein kinase Iepsilon-mediated phosphorylation. Curr Biol (2004) 0.98
Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2008) 0.98