Published in Genes Dev on March 11, 2015
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One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci (2016) 1.08
piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals. RNA (2015) 0.88
Long non-coding RNA regulation of reproduction and development. Mol Reprod Dev (2015) 0.82
CLIPSeqTools-a novel bioinformatics CLIP-seq analysis suite. RNA (2015) 0.81
Multiple LINEs of retrotransposon silencing mechanisms in the mammalian germline. Semin Cell Dev Biol (2016) 0.81
RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Genes Dev (2015) 0.80
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Peripheral blood methylation profiling of female Crohn's disease patients. Clin Epigenetics (2016) 0.77
Kc167, a widely used Drosophila cell line, contains an active primary piRNA pathway. RNA (2016) 0.76
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Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice. Biol Reprod (2016) 0.75
Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A (2017) 0.75
Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell (2017) 0.75
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature (2009) 14.07
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
A distinct small RNA pathway silences selfish genetic elements in the germline. Science (2006) 11.63
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science (2007) 10.73
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
A novel class of small RNAs bind to MILI protein in mouse testes. Nature (2006) 8.80
Characterization of the piRNA complex from rat testes. Science (2006) 7.86
Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization. J Cell Biol (1977) 7.69
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev (1998) 6.74
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev (2006) 6.60
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A novel class of small RNAs in mouse spermatogenic cells. Genes Dev (2006) 5.85
miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell (2002) 5.85
PIWI-interacting small RNAs: the vanguard of genome defence. Nat Rev Mol Cell Biol (2011) 5.59
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development (2004) 5.47
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev (2007) 4.68
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell (2009) 4.39
Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development (2001) 4.13
SF1 and SF2 helicases: family matters. Curr Opin Struct Biol (2010) 3.79
A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature (2009) 3.68
NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol (2012) 3.64
Cre-mediated chromosome loss in mice. Nat Genet (1997) 3.36
zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell (2007) 3.29
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Cell (2012) 3.04
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell (2009) 2.96
Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini. Nat Struct Mol Biol (2007) 2.89
Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev Cell (2007) 2.86
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein. Mol Cell Biol (1996) 2.78
piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev Cell (2011) 2.73
A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol (2009) 2.69
Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature (1996) 2.63
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell (2010) 2.53
Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line. Mol Cell Biol (2004) 2.44
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol (2009) 2.42
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev (2010) 2.33
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature (2011) 2.11
3' end formation of PIWI-interacting RNAs in vitro. Mol Cell (2011) 2.05
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature (2012) 1.97
Multiple roles for Piwi in silencing Drosophila transposons. Genes Dev (2013) 1.96
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature (2012) 1.90
A major epigenetic programming mechanism guided by piRNAs. Dev Cell (2013) 1.89
Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila. Genes Dev (2010) 1.84
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature (2011) 1.77
The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA (2007) 1.77
Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol (2012) 1.70
MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A (2010) 1.66
Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol (2006) 1.59
Hen1 is required for oocyte development and piRNA stability in zebrafish. EMBO J (2010) 1.53
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A (2010) 1.52
5'-UTR G-quadruplex structures acting as translational repressors. Nucleic Acids Res (2010) 1.49
Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells. Nat Chem (2013) 1.48
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet (2012) 1.36
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA (2008) 1.34
The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol Cell (2012) 1.34
piRNAs and their involvement in male germline development in mice. Dev Growth Differ (2012) 1.31
Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis. Mol Cell (2013) 1.29
A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell (2012) 1.26
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J (2013) 1.22
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Mol Cell (2014) 1.17
shutdown is a component of the Drosophila piRNA biogenesis machinery. RNA (2012) 1.10
Mitochondrial protein BmPAPI modulates the length of mature piRNAs. RNA (2013) 1.07
A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology. Biochemistry (2011) 1.04
Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet (2012) 1.00
Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc. RNA (2012) 1.00
Duplex unwinding with DEAD-box proteins. Methods Mol Biol (2010) 0.96
Hsp90 facilitates accurate loading of precursor piRNAs into PIWI proteins. RNA (2013) 0.93
Stage-specific synthesis and fucosylation of plasma membrane proteins by mouse pachytene spermatocytes and round spermatids in culture. Biol Reprod (1986) 0.83
HITS-CLIP (CLIP-Seq) for mouse Piwi proteins. Methods Mol Biol (2014) 0.81