Published in J Mol Biol on October 05, 1989
Pre-mRNA splicing within an assembled yeast spliceosome requires an RNA-dependent ATPase and ATP hydrolysis. Proc Natl Acad Sci U S A (1993) 1.62
Evaluation of splicing efficiency in lymphoblastoid cell lines from patients with splicing-factor retinitis pigmentosa. Mol Vis (2008) 0.85
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucleic Acids Res (1979) 21.96
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information. Annu Rev Biochem (1986) 11.03
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell (1993) 10.36
The evolution of genes: the chicken preproinsulin gene. Cell (1980) 10.25
A bacterial clone synthesizing proinsulin. Proc Natl Acad Sci U S A (1978) 10.23
Role of insulin-like growth factors in embryonic and postnatal growth. Cell (1993) 8.22
The nucleotide sequence of the human beta-globin gene. Cell (1980) 8.11
Parental imprinting of the mouse insulin-like growth factor II gene. Cell (1991) 7.11
End labeling of enzymatically decapped mRNA. Nucleic Acids Res (1977) 6.58
Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (1995) 6.18
Insertion of synthetic copies of human globin genes into bacterial plasmids. Nucleic Acids Res (1978) 5.99
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31
Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell (1975) 3.83
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev (1997) 3.83
Construction and characterization of a normalized cDNA library. Proc Natl Acad Sci U S A (1994) 3.73
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet (1995) 3.72
In vivo splicing products of the rabbit beta-globin pre-mRNA. Cell (1984) 3.35
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol (2001) 3.13
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet (2000) 2.95
Conformation of promoter DNA: fine mapping of S1-hypersensitive sites. Cell (1983) 2.90
The structure and transcription of four linked rabbit beta-like globin genes. Cell (1979) 2.81
Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood (2001) 2.73
Molecular evolution of human and rabbit beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.70
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol (1994) 2.65
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A (1993) 2.58
The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 gene defines a glutathione-dependent pathway involved in initiation and maintenance of cell division during postembryonic root development. Plant Cell (2000) 2.51
RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol Cell Biol (1985) 2.35
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev (1997) 2.25
Pre-mRNA splicing and the nuclear matrix. Mol Cell Biol (1987) 2.22
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol (1996) 2.15
Sequence-dependent S1 nuclease hypersensitivity of a heteronomous DNA duplex. J Biol Chem (1986) 2.15
Effects of an Igf1 gene null mutation on mouse reproduction. Mol Endocrinol (1996) 2.08
CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis (2000) 2.04
Anaesthesia for caesarean section in a patient with Charcot-Marie-Tooth disease. Anaesthesia (1998) 2.03
Fractionation of low molecular weight DNA or RNA in polyacrylamide gels containing 98% formamide or 7 M urea. Methods Enzymol (1980) 1.98
Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev (2001) 1.94
Training in obstetric general anaesthesia: a vanishing art? Anaesthesia (2000) 1.94
S1-hypersensitive sites in eukaryotic promoter regions. Nucleic Acids Res (1984) 1.88
"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene. Proc Natl Acad Sci U S A (1985) 1.87
Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Nucleic Acids Res (1985) 1.84
Localization of the binding site for protein S4 on 16 S ribosomal RNA by chemical and enzymatic probing and primer extension. J Mol Biol (1986) 1.83
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol (1997) 1.80
Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice. Neuroscience (2008) 1.76
Cell-specified expression of a selectable hybrid gene. Proc Natl Acad Sci U S A (1984) 1.74
Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family. J Mol Biol (1986) 1.72
Use of a cDNA library for studies on evolution and developmental expression of the chorion multigene families. Cell (1979) 1.72
Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes. Mamm Genome (2000) 1.71
Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics (1997) 1.68
Electrophoretic patterns of deadenylylated chorion and globin mRNAs. Proc Natl Acad Sci U S A (1975) 1.67
Possible structures of homopurine-homopyrimidine S1-hypersensitive sites. Nucleic Acids Res (1984) 1.67
Resistance to several steroids in two sisters. J Clin Endocrinol Metab (1999) 1.57
The eggshell of insects: differentiation-specific proteins and the control of their synthesis and accumulation during development. Results Probl Cell Differ (1977) 1.56
Congenital adrenal hyperplasia (21-hydroxylase deficiency) without demonstrable genetic mutations. J Clin Endocrinol Metab (1999) 1.52
Variations in hospitalization rates for asthma among black and minority ethnic communities. Respir Med (1998) 1.51
Regional blockade for delivery in women with scoliosis or previous spinal surgery. Int J Obstet Anesth (2003) 1.50
Autonomous splicing and complementation of in vivo-assembled spliceosomes. J Cell Biol (1989) 1.49
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease. J Neurosci Res (1999) 1.48
Minimal exon sequence requirements for efficient in vitro splicing of mono-intronic nuclear pre-mRNA. J Biol Chem (1987) 1.48
The 3' noncoding region of beta-globin mRNA is not essential for in vitro translation. Nucleic Acids Res (1979) 1.46
Rat LINE1: the origin and evolution of a family of long interspersed middle repetitive DNA elements. J Mol Evol (1985) 1.36
Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet (1999) 1.36
Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues. Development (1998) 1.35
Cloning of PCR-amplified total cDNA: construction of a mouse oocyte cDNA library. Genet Anal Tech Appl (1990) 1.31
Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development (1990) 1.30
Pattern of the insulin-like growth factor II gene expression during rat embryogenesis. Development (1988) 1.26
Guinea pig preproinsulin gene: an evolutionary compromise? Proc Natl Acad Sci U S A (1984) 1.24
A promoter of the rat insulin-like growth factor II gene consists of minimal control elements. J Mol Biol (1988) 1.23
Prenatal diagnosis for congenital adrenal hyperplasia in 532 pregnancies. J Clin Endocrinol Metab (2001) 1.23
Central electrophysiologic correlates of pulsatile luteinizing hormone secretion in the rhesus monkey. Neuroendocrinology (1984) 1.22
Detection of a sub-set of polysomal mRNAs associated with modulation of hypusine formation at the G1-S boundary. Proposal of a role for eIF-5A in onset of DNA replication. FEBS Lett (1995) 1.21
Cloning vectors for expression of cDNA libraries in mammalian cells. Proc Natl Acad Sci U S A (1987) 1.19
Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci U S A (1997) 1.19
Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene (2001) 1.18
Synthesis of stable unspliced mRNA from an intronless simian virus 40--rat preproinsulin gene recombinant. Proc Natl Acad Sci U S A (1981) 1.18
Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci (1998) 1.16
Variations in admissions to hospital for head injury and assault to the head. Part 1: Age and gender. Br J Oral Maxillofac Surg (1999) 1.15
Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in Caesarean section. Br J Anaesth (2005) 1.12
Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease. Exp Neurol (2000) 1.11
Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. Development (1993) 1.11
Variations in admission to hospital for head injury and assault to the head. Part 2: Ethnic group. Br J Oral Maxillofac Surg (1999) 1.08
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess. J Clin Endocrinol Metab (1998) 1.08
Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells. Cancer Res (1995) 1.07
Avian fracture healing. J Am Vet Med Assoc (1977) 1.07
Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess. Proc Natl Acad Sci U S A (1999) 1.05
Radiotelemetric monitoring of hypothalamic gonadotropin-releasing hormone pulse generator activity throughout the menstrual cycle of the rhesus monkey. Endocrinology (1991) 1.01