Published in Prog Biophys Mol Biol on March 01, 2015
Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature (1953) 47.27
Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov (2004) 15.57
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys (2007) 9.07
The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature (2003) 8.68
DNA repair pathways as targets for cancer therapy. Nat Rev Cancer (2008) 6.69
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature (2001) 6.29
The double helix: a personal view. Nature (1974) 4.56
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature (1996) 4.46
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. Nature (2000) 4.40
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell (2008) 4.26
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell (2001) 3.81
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
Accurate assessment of mass, models and resolution by small-angle scattering. Nature (2013) 3.18
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell (2008) 3.14
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell (2009) 2.90
Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet (2003) 2.88
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law. Biopolymers (2011) 2.87
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. Cell (2000) 2.73
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. Cell (2011) 2.44
Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. Nature (1984) 2.36
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. DNA Repair (Amst) (2007) 2.26
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell (2006) 2.23
DNA base damage recognition and removal: new twists and grooves. Mutat Res (2005) 2.21
Structure of the DNA repair helicase XPD. Cell (2008) 2.16
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature (2009) 1.97
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst) (2010) 1.96
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell (2013) 1.93
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell (2011) 1.73
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol (1999) 1.62
The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. J Biol Chem (1989) 1.60
Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc Natl Acad Sci U S A (2014) 1.50
Protein mimicry of DNA and pathway regulation. DNA Repair (Amst) (2005) 1.46
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase. DNA Repair (Amst) (2011) 1.45
Comprehensive macromolecular conformations mapped by quantitative SAXS analyses. Nat Methods (2013) 1.29
Therapeutic opportunities within the DNA damage response. Nat Rev Cancer (2015) 1.29
Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation. EMBO J (2011) 1.28
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol (2008) 1.25
Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy. Cancer Discov (2014) 1.21
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J (2014) 1.14
Cancer, cadmium and genome integrity. Nat Genet (2003) 1.11
Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery. Q Rev Biophys (2012) 1.09
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. Prog Biophys Mol Biol (2015) 1.07
The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once. DNA Repair (Amst) (2014) 1.04
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. DNA Repair (Amst) (2014) 1.03
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c. J Biol Chem (1991) 0.98
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol (2014) 0.96
DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals. Proc Natl Acad Sci U S A (2013) 0.95
The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. J Mol Biol (2013) 0.93
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. J Biol Chem (2010) 0.92
The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures. FEBS J (2014) 0.88
DNA ligases as therapeutic targets. Transl Cancer Res (2013) 0.85
Structure of the Rad50 DNA double-strand break repair protein in complex with DNA. EMBO J (2014) 0.83
Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal. Prog Biophys Mol Biol (2015) 0.82
I came to a fork in the DNA and there was RecG. Prog Biophys Mol Biol (2015) 0.82
Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA. Prog Biophys Mol Biol (2014) 0.81
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease. Prog Biophys Mol Biol (2015) 0.81
Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif. Prog Biophys Mol Biol (2015) 0.79
XPB: An unconventional SF2 DNA helicase. Prog Biophys Mol Biol (2015) 0.78
Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair. Cold Spring Harb Symp Quant Biol (2000) 0.76
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V. Prog Biophys Mol Biol (2015) 0.75