Published in Cell on October 27, 2000
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol (2006) 2.83
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. EMBO J (2002) 2.62
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol (2007) 2.54
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev (2009) 2.50
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev (2009) 2.44
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev (2009) 1.96
Autoantigen discovery with a synthetic human peptidome. Nat Biotechnol (2011) 1.90
Replication protein A: directing traffic at the intersection of replication and repair. Front Biosci (Landmark Ed) (2010) 1.77
Identification of SMARCAL1 as a component of the DNA damage response. J Biol Chem (2009) 1.74
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair. EMBO J (2001) 1.74
Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions. Mol Cell Biol (2003) 1.68
Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.58
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res (2004) 1.56
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome. Nat Struct Mol Biol (2005) 1.50
Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair. Mol Cell (2015) 1.49
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Mol Cell Biol (2003) 1.48
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO J (2007) 1.46
Functional dynamics in replication protein A DNA binding and protein recruitment domains. Structure (2015) 1.40
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Biochemistry (2006) 1.38
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem (2010) 1.37
Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch. EMBO J (2004) 1.36
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. Nucleic Acids Res (2007) 1.30
Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem (2005) 1.29
Structural basis for the recognition of methylated histone H3K36 by the Eaf3 subunit of histone deacetylase complex Rpd3S. Structure (2008) 1.29
Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J (2006) 1.25
The MukF subunit of Escherichia coli condensin: architecture and functional relationship to kleisins. EMBO J (2005) 1.24
Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase. Proc Natl Acad Sci U S A (2010) 1.21
HARPing on about the DNA damage response during replication. Genes Dev (2009) 1.21
Identification of the SSB binding site on E. coli RecQ reveals a conserved surface for binding SSB's C terminus. J Mol Biol (2009) 1.20
Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes. Nucleic Acids Res (2010) 1.19
Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc Natl Acad Sci U S A (2009) 1.19
Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem (2009) 1.19
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Crystal structure of an mRNA-binding fragment of Moorella thermoacetica elongation factor SelB. EMBO J (2002) 1.17
Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA. Biochemistry (2005) 1.14
A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Res (2013) 1.12
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition. Mutat Res (2009) 1.09
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. Oncogene (2012) 1.07
Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. Biochemistry (2010) 1.04
Torsional regulation of hRPA-induced unwinding of double-stranded DNA. Nucleic Acids Res (2010) 1.01
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol (2008) 1.01
Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein. Proc Natl Acad Sci U S A (2005) 1.00
Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular ruler. Biochemistry (2007) 0.99
Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Res (2011) 0.99
Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem (2009) 0.99
Archaeology of eukaryotic DNA replication. Cold Spring Harb Perspect Biol (2013) 0.98
Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett (2013) 0.95
ETAA1 acts at stalled replication forks to maintain genome integrity. Nat Cell Biol (2016) 0.95
Human replication protein A-Rad52-single-stranded DNA complex: stoichiometry and evidence for strand transfer regulation by phosphorylation. Biochemistry (2009) 0.94
Activation of the ATR kinase by the RPA-binding protein ETAA1. Nat Cell Biol (2016) 0.94
Identification of plant RAD52 homologs and characterization of the Arabidopsis thaliana RAD52-like genes. Plant Cell (2011) 0.94
An alternative form of replication protein a expressed in normal human tissues supports DNA repair. J Biol Chem (2009) 0.93
APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion. Cancer Res (2013) 0.92
BID binds to replication protein A and stimulates ATR function following replicative stress. Mol Cell Biol (2011) 0.91
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res (2012) 0.90
Mutational analysis of simian virus 40 T-antigen primosome activities in viral DNA replication. J Virol (2002) 0.90
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch. Nat Commun (2014) 0.90
Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA). J Biol Chem (2008) 0.89
XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase. PLoS One (2011) 0.88
Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1. J Virol (2011) 0.88
Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. J Biol Chem (2011) 0.87
The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat Struct Mol Biol (2015) 0.85
UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. PLoS One (2013) 0.85
Structural anatomy of telomere OB proteins. Crit Rev Biochem Mol Biol (2011) 0.84
Redefining the DNA-binding domain of human XPA. J Am Chem Soc (2014) 0.83
Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins. Mol Cell (2015) 0.83
Structural analysis of replication protein A recruitment of the DNA damage response protein SMARCAL1. Biochemistry (2014) 0.83
Other proteins interacting with XP proteins. Adv Exp Med Biol (2008) 0.82
Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure (2015) 0.82
Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus. Proteins (2009) 0.81
Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA. Prog Biophys Mol Biol (2014) 0.81
Dynamic binding of replication protein a is required for DNA repair. Nucleic Acids Res (2016) 0.80
Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex. Nucleic Acids Res (2014) 0.80
Preparation of the modular multi-domain protein RPA for study by NMR spectroscopy. Methods Mol Biol (2012) 0.78
Denaturation of replication protein A reveals an alternative conformation with intact domain structure and oligonucleotide binding activity. Protein Sci (2004) 0.78
Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis. Biophys J (2017) 0.78
Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans. Biochem J (2013) 0.77
Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Nucleic Acids Res (2005) 0.77
Predicting protein-DNA interactions by full search computational docking. Proteins (2013) 0.77
Sample preparation methods to analyze DNA-induced structural changes in replication protein A. Methods Mol Biol (2012) 0.76
Role of the XPA protein in the NER pathway: A perspective on the function of structural disorder in macromolecular assembly. Comput Struct Biotechnol J (2015) 0.75
Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination. Retrovirology (2016) 0.75
Replication-mediated disassociation of replication protein A-XPA complex upon DNA damage: implications for RPA handing off. Cell Biol Int (2012) 0.75
Dynamic structures in DNA damage responses & cancer. Prog Biophys Mol Biol (2015) 0.75
XPA: A key scaffold for human nucleotide excision repair. DNA Repair (Amst) (2016) 0.75
Crystal structure of mimivirus uracil-DNA glycosylase. PLoS One (2017) 0.75
Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem (2017) 0.75
The phylogeny of prokaryotes. Science (1980) 24.57
Detailed analysis of the higher-order structure of 16S-like ribosomal ribonucleic acids. Microbiol Rev (1983) 23.08
Timing the ancestor of the HIV-1 pandemic strains. Science (2000) 10.42
Secondary structure model for bacterial 16S ribosomal RNA: phylogenetic, enzymatic and chemical evidence. Nucleic Acids Res (1980) 9.50
Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases. Cell (1985) 8.45
Secondary structure model for 23S ribosomal RNA. Nucleic Acids Res (1981) 7.12
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID. Nature (1990) 7.11
Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet (2009) 6.83
Community-based treatment of advanced HIV disease: introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull World Health Organ (2001) 6.07
Sequence of the 16S Ribosomal RNA from Halobacterium volcanii, an Archaebacterium. Science (1983) 5.66
Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India (2009) 5.45
Architecture of RNA polymerase II and implications for the transcription mechanism. Science (2000) 5.12
The phylogeny of purple bacteria: the alpha subdivision. Syst Appl Microbiol (1984) 4.96
Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Nature (1997) 4.61
Speaking the same language: treatment outcome definitions for multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2005) 4.57
Homology requirements for recombination in Escherichia coli. Proc Natl Acad Sci U S A (1985) 4.46
Screening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies. BMJ (2001) 4.15
Were the original eubacteria thermophiles? Syst Appl Microbiol (1987) 4.06
Mianserin hydrochloride: a novel antidepressant. Br J Psychiatry (1976) 3.92
Rooting the archaebacterial tree: the pivotal role of Thermococcus celer in archaebacterial evolution. Syst Appl Microbiol (1988) 3.76
Factors affecting uptake of antenatal HIV testing in London: results of a multicentre study. BMJ (1998) 3.72
Putative introns in tRNA genes of prokaryotes. Proc Natl Acad Sci U S A (1983) 3.60
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. Mol Cell Biol (1994) 3.46
Structural proteomics of an archaeon. Nat Struct Biol (2000) 3.46
Analgesic efficacy of pre-operative stellate ganglion block on postoperative pain relief: a randomised controlled trial. Anaesthesia (2014) 3.30
The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function. Mol Cell Biol (1988) 3.26
Halobacterium volcanii tRNAs. Identification of 41 tRNAs covering all amino acids, and the sequences of 33 class I tRNAs. J Biol Chem (1984) 3.25
Sequence of the 16S rRNA gene from the thermoacidophilic archaebacterium Sulfolobus solfataricus and its evolutionary implications. J Mol Evol (1985) 3.20
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature (1995) 3.06
Adverse events in the treatment of multidrug-resistant tuberculosis: results from the DOTS-Plus initiative. Int J Tuberc Lung Dis (2004) 2.87
Antimicrobial susceptibility and frequency of occurrence of clinical blood isolates in Europe from the SENTRY antimicrobial surveillance program, 1997 and 1998. Clin Infect Dis (2000) 2.87
Herpes simplex virus triggers and then disarms a host antiviral response. J Virol (2001) 2.82
Prediction of human protein function according to Gene Ontology categories. Bioinformatics (2003) 2.54
Transcription and excision of a large intron in the tRNATrp gene of an archaebacterium, Halobacterium volcanii. J Biol Chem (1985) 2.45
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol Cell Biol (1995) 2.44
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet (1998) 2.34
The transactivator proteins VP16 and GAL4 bind replication factor A. Cell (1993) 2.32
Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. Cell (1996) 2.25
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr Biol (1997) 2.24
Rotational diffusion anisotropy of proteins from simultaneous analysis of 15N and 13C alpha nuclear spin relaxation. J Biomol NMR (1997) 2.18
Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing. Immunity (1997) 2.18
The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. EMBO J (1999) 2.15
Blood pressure cuffs: friend or foe? J Hosp Infect (2006) 2.15
Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein. J Biol Chem (1993) 2.15
Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol (1995) 2.13
Itopride in functional dyspepsia: results of two phase III multicentre, randomised, double-blind, placebo-controlled trials. Gut (2007) 2.11
EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance. J Virol (1999) 2.07
Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein. Mol Cell Biol (1994) 2.07
Lymphatic manifestations of lymphangioleiomyomatosis. Lymphology (2014) 2.06
With a pinch of salt. Clin Med (2010) 2.06
Prediction of human protein function from post-translational modifications and localization features. J Mol Biol (2002) 2.05
Sodium cromoglicate: an ineffective drug or meta-analysis misused? Pharm Stat (2007) 2.02
Surgical decisions in the elderly: the importance of biological age. J R Soc Med (2001) 2.02
Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis. Plant Cell (1999) 2.02
Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India (2001) 2.01
Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1. Cell (1995) 1.87
Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding. EMBO J (2001) 1.87
The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry (1995) 1.84
Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial dna mutant. J Biol Chem (2000) 1.80
Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke. Neurology (2008) 1.80
Recombination activities of HsDmc1 protein, the meiotic human homolog of RecA protein. Proc Natl Acad Sci U S A (1997) 1.79
Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS. J Biol Chem (1997) 1.79
The phylogenetic relationships of three sulfur dependent archaebacteria. Syst Appl Microbiol (1984) 1.79
Mutations in RNA polymerase II enhance or suppress mutations in GAL4. Proc Natl Acad Sci U S A (1989) 1.78
Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14). J Infect Dis (2000) 1.76
High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14. J Biol Chem (1998) 1.76
Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms. Biochemistry (1997) 1.73
Identification, molecular cloning, and mutagenesis of Saccharomyces cerevisiae RNA polymerase genes. Proc Natl Acad Sci U S A (1984) 1.72
Pseudomonas aeruginosa community-acquired pneumonia in previously healthy adults: case report and review of the literature. Clin Infect Dis (2000) 1.72
Waist circumference cutoff points and action levels for Asian Indians for identification of abdominal obesity. Int J Obes (Lond) (2006) 1.71
RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability. Yeast (1993) 1.71
Total hip arthroplasty in ankylosing spondylitis: outcome in 340 patients. J Rheumatol (2001) 1.71
Multiple retinal haemorrhages (decompression retinopathy) following paracentesis for macular branch artery occlusion. Eye (Lond) (2005) 1.70
Improved survival in the treatment of squamous carcinoma of the oral tongue. Am J Surg (1993) 1.69
Amphotericin B lipid complex compared with amphotericin B in the treatment of cryptococcal meningitis in patients with AIDS. Clin Infect Dis (1996) 1.68
Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest (2001) 1.66
Prevalence of tobacco use and awareness of risks among school children in Jaipur. J Assoc Physicians India (2006) 1.66
Distinction between hyperaldosteronism due to bilateral hyperplasia and unilateral aldosteronoma: reliability of CT. Radiology (1992) 1.66
Effect of a chimeric antibody to tumor necrosis factor-alpha on cytokine and physiologic responses in patients with severe sepsis--a randomized, clinical trial. Crit Care Med (1998) 1.65
Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN). Neurology (2008) 1.60
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis (1998) 1.59
Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria). J Bacteriol (1991) 1.57
Mouse B7-H3 induces antitumor immunity. Gene Ther (2003) 1.57
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
The burden of drug-resistant tuberculosis and mechanisms for its control. Ann N Y Acad Sci (2001) 1.55
Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. Neurology (2004) 1.55
The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain. J Biol Chem (1998) 1.55
Ascitic fluid cholesterol in malignant and tubercular ascites. J Assoc Physicians India (1995) 1.54
Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases. Plant Physiol (2000) 1.53
Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos. Nature (1992) 1.53
SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics. Nucleic Acids Res (2001) 1.52
Structure of a modified nucleoside in archaebacterial tRNA which replaces ribosylthymine. 1-Methylpseudouridine. J Biol Chem (1982) 1.51