Published in J Biol Chem on October 15, 1989
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol (1990) 3.30
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci U S A (1995) 2.99
A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol (1990) 2.95
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
Post-translational modifications of Hsp90 and their contributions to chaperone regulation. Biochim Biophys Acta (2011) 1.56
The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo. Mol Cell Biol (1994) 1.54
Hsp90: A New Player in DNA Repair? Biomolecules (2015) 1.45
Heat shock proteins: cellular and molecular mechanisms in the central nervous system. Prog Neurobiol (2010) 1.37
Hsp90, an unlikely ally in the war on cancer. FEBS J (2013) 1.33
Phosphorylation sites in the amino-terminal region of mouse p53. Proc Natl Acad Sci U S A (1992) 1.18
Gene expression profiles of cytosolic heat shock proteins Hsp70 and Hsp90 from symbiotic dinoflagellates in response to thermal stress: possible implications for coral bleaching. Cell Stress Chaperones (2010) 1.13
Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci. J Biol Chem (2012) 1.10
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucleic Acids Res (1993) 1.04
The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites. J Virol (1991) 1.02
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci U S A (2012) 1.01
Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy. Curr Mol Med (2012) 0.99
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol (2014) 0.96
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity. Oncotarget (2011) 0.96
DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes: involvement of protein phosphorylation in nucleosome spacing. EMBO J (1991) 0.94
Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code. Biochim Biophys Acta (2013) 0.90
Plastid casein kinase 2 knockout reduces abscisic acid (ABA) sensitivity, thermotolerance, and expression of ABA- and heat-stress-responsive nuclear genes. J Exp Bot (2014) 0.88
A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells. J Proteome Res (2006) 0.87
Hsp-90 and the biology of nematodes. BMC Evol Biol (2009) 0.86
Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins. Proc Natl Acad Sci U S A (2001) 0.86
Dimerization and DNA binding alter phosphorylation of Fos and Jun. Proc Natl Acad Sci U S A (1993) 0.84
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. Am J Physiol Cell Physiol (2008) 0.84
Alternative approaches to Hsp90 modulation for the treatment of cancer. Future Med Chem (2014) 0.84
Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex. Am J Physiol Cell Physiol (2011) 0.83
Regulation and function of the human HSP90AA1 gene. Gene (2015) 0.80
DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation. PLoS One (2013) 0.79
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J Biol Chem (2009) 0.79
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells. Nucleic Acids Res (2013) 0.78
Cloning and characterization of the HSP90 beta gene from Tanichthys albonubes Lin (Cyprinidae): effect of copper and cadmium exposure. Fish Physiol Biochem (2011) 0.76
Dynamic structures in DNA damage responses & cancer. Prog Biophys Mol Biol (2015) 0.75
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab (2017) 0.75
ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation. Oncotarget (2016) 0.75
Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition. Sci Rep (2016) 0.75
Safety control for apoptotic irreversibility. Proc Natl Acad Sci U S A (2012) 0.75
Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature (1981) 16.61
Processing of adenovirus 2-induced proteins. J Virol (1973) 12.52
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein. Cell (1986) 5.53
Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. Proc Natl Acad Sci U S A (1982) 5.50
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas. Cell (1988) 5.49
Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem (2001) 5.43
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64
Mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments. Proc Natl Acad Sci U S A (1975) 4.35
Identification of the SV40 agnogene product: a DNA binding protein. Nature (1981) 3.80
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68
Identification of the initiation site of poliovirus polyprotein synthesis. J Virol (1982) 3.62
Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus. Proc Natl Acad Sci U S A (1983) 3.58
Location and identification of the genes for adenovirus type 2 early polypeptides. Cell (1976) 3.58
Cell-free synthesis of adenovirus 2 proteins programmed by fractionated messenger RNA: a comparison of polypeptide products and messenger RNA lengths. Proc Natl Acad Sci U S A (1974) 3.52
A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature (1996) 3.50
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J (1999) 3.46
Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells. J Virol (1984) 3.38
Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon. Proc Natl Acad Sci U S A (1985) 3.31
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol (1990) 3.30
Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides. Virology (1983) 3.28
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide. Cell (1982) 3.07
Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing. Proc Natl Acad Sci U S A (1981) 2.91
Further mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments. Cell (1977) 2.78
Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem (1995) 2.62
DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats. Genes Dev (1992) 2.56
Preparation of a cell-free protein-synthesizing system from wheat germ. Methods Enzymol (1983) 2.43
Normal tRNAs promote ribosomal frameshifting. Cell (1979) 2.41
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38
Identification and characterization of an immunologically conserved adenovirus early region 11,000 Mr protein and its association with the nuclear matrix. J Mol Biol (1982) 2.36
Pattern of protein synthesis in monkey cells infected by simian virus 40. J Virol (1972) 2.35
Protein processing map of poliovirus. J Virol (1984) 2.33
Expression of a cloned gene segment of poliovirus in E. coli: evidence for autocatalytic production of the viral proteinase. Cell (1984) 2.29
The amino acid sequence of murine p53 determined from a c-DNA clone. Virology (1984) 2.15
Block to multiplication of adenovirus serotype 2 in monkey cells. J Virol (1975) 2.10
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem (2000) 2.08
Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem (1992) 2.08
Cleavage sites in the polypeptide precursors of poliovirus protein P2-X. Virology (1981) 2.04
Adenovirus type 2 early proteins: assignment of the early region 1A proteins synthesized in vivo and in vitro to specific mRNAs. Virology (1981) 2.04
Cleavage sites within the poliovirus capsid protein precursors. J Virol (1982) 1.95
Enhanced differential synthesis of proteins in a mammalian cell-free system by addition of polyamines. J Biol Chem (1975) 1.93
Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor. Nat Struct Biol (2001) 1.91
Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity. Nature (1993) 1.86
Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J Biol Chem (1997) 1.84
A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J Biol Chem (1995) 1.82
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A (2000) 1.80
The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc Natl Acad Sci U S A (1994) 1.79
Conditional lethal mutants of adenovirus type 2-simian virus 40 hybrids. II. Ad2+ND1 host-range mutants that synthesize fragments of the Ad2+ND1 30K protein. J Virol (1976) 1.76
Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells. Proc Natl Acad Sci U S A (1986) 1.72
Signaling to p53: breaking the posttranslational modification code. Pathol Biol (Paris) (2000) 1.67
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry (1997) 1.66
Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts. EMBO J (1985) 1.64
Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene (1993) 1.63
Binding of mammalian ribosomes to MS2 phage RNA reveals an overlapping gene encoding a lysis function. Cell (1979) 1.56
Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II. J Biol Chem (1989) 1.56
DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J Biol Chem (1994) 1.56
Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residues. J Virol (1984) 1.51
Poliovirus RNA synthesis in vitro: structural elements and antibody inhibition. Virology (1983) 1.51
Interaction of human adenovirus serotype 2 with human lymphoid cells. Virology (1988) 1.49
The origin and destiny of adenovirus proteins. Cold Spring Harb Symp Quant Biol (1975) 1.46
Adenovirus coded deoxyribonucleic acid binding protein. Isolation, physical properties, and effects of proteolytic digestion. Biochemistry (1980) 1.46
Breakdown and exclusion of superinfecting T-even bacteriophage in Escherichia coli. J Virol (1971) 1.43
Can ACG serve as an initiation codon for protein synthesis in eucaryotic cells? Mol Cell Biol (1985) 1.41
The p53 tumor suppressor protein, a modulator of cell proliferation. J Biol Chem (1992) 1.41
Amino-terminal sequence of adenovirus type 2 proteins: hexon, fiber, component IX, and early protein 1B-15K. Virology (1980) 1.39
Polypeptide structure and encoding location of the adenovirus serotype 2 late, nonstructural 33K protein. J Virol (1983) 1.28
Catalysis of poliovirus VP0 maturation cleavage is not mediated by serine 10 of VP2. J Virol (1991) 1.25
The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities. Oncogene (1994) 1.15
Simian virus 40-specific polypeptides in AD2+ ND1- and Ad2+ ND4-infected cells. J Virol (1976) 1.13
Redox-mediated regulation of p21(waf1/cip1) expression involves a post-transcriptional mechanism and activation of the mitogen-activated protein kinase pathway. Eur J Biochem (1997) 1.12
Bacteriophage T3 and T7 early RNAs are translated by eukaryotic 80S ribosomes: active phage T3 coded S-adenosylmethionine cleaving enzyme is synthesized. Proc Natl Acad Sci U S A (1976) 1.11
Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc Natl Acad Sci U S A (1995) 1.11
The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. Genomics (1998) 1.11
Changing trends in the indications for penetrating keratoplasty. Arch Ophthalmol (1992) 1.10
Drosophila proliferating cell nuclear antigen. Structural and functional homology with its mammalian counterpart. J Biol Chem (1990) 1.10
Localization of parental deoxyribonucleic acid from superinfecting T4 bacteriophage in Escherichia coli. J Virol (1971) 1.10
Adenovirus interaction with its cellular receptor CAR. Curr Top Microbiol Immunol (2003) 1.10
Spontaneous mutants of the adenovirus-simian virus 40 hybrid, Ad2+ND3, that grow efficiently in monkey cells. Virology (1981) 1.10
Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents. J Biol Chem (2000) 1.06
DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues. Oncogene (1999) 1.04
The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events. Cancer Cells (1991) 1.04
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes. Mol Carcinog (1997) 1.04
Proteins encoded near the adenovirus late messenger RNA leader segments. Virology (1983) 1.03
The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites. J Virol (1991) 1.02
Adenovirus type 2 expresses fiber in monkey-human hybrids and reconstructed cells. J Virol (1981) 1.01
The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. J Biol Chem (1991) 1.01
Adenovirus type 2 terminal protein: purification and comparison of tryptic peptides with known adenovirus-coded proteins. J Virol (1979) 0.99
Presence in infected cells of nonvirion proteins encoded by adenovirus messenger RNAs of the major late transcription regions L0 and L1. Virology (1985) 0.98
Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53. Proc Natl Acad Sci U S A (1993) 0.97
Spontaneous deletion formation in several classes of Escherichia coli mutants deficient in recombination ability. Mutat Res (1970) 0.97
Identification of adenovirus type 2 early region 1B proteins that share the same amino terminus as do the 495R and 155R proteins. J Virol (1987) 0.94