Published in Nat Genet on June 08, 2015
Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet (2016) 1.32
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nat Genet (2016) 1.03
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet (2016) 0.89
Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet (2016) 0.88
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet (2016) 0.85
Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet (2017) 0.82
Dissecting the genetics of complex traits using summary association statistics. Nat Rev Genet (2016) 0.80
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78
Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Nat Genet (2016) 0.77
Constraints on eQTL Fine Mapping in the Presence of Multi-site Local Regulation of Gene Expression. G3 (Bethesda) (2017) 0.77
Update on the genetic architecture of rheumatoid arthritis. Nat Rev Rheumatol (2016) 0.76
A method for identifying genetic heterogeneity within phenotypically defined disease subgroups. Nat Genet (2016) 0.75
Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Nat Genet (2015) 0.75
Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis. Hum Mol Genet (2015) 0.75
Joint genetic analysis using variant sets reveals polygenic gene-context interactions. PLoS Genet (2017) 0.75
Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era. Genome Biol (2017) 0.75
Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation. Cancer Inform (2016) 0.75
Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives. Mult Scler Int (2017) 0.75
Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. Am J Hum Genet (2017) 0.75
Immunogenomic approaches to understand the function of immune disease variants. Immunology (2017) 0.75
The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age. Diabetologia (2017) 0.75
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Why most discovered true associations are inflated. Epidemiology (2008) 11.22
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Promise and pitfalls of the Immunochip. Arthritis Res Ther (2011) 5.38
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun (2008) 3.48
Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet (2013) 2.85
A statistical framework for joint eQTL analysis in multiple tissues. PLoS Genet (2013) 2.46
What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. Int J Epidemiol (2011) 2.13
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet (2015) 2.04
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics (2008) 1.72
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet (2014) 1.71
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'. Eur J Hum Genet (2014) 1.41
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet (2012) 1.20
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. J Clin Endocrinol Metab (2013) 1.14
An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes (2011) 1.13
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. Eur J Hum Genet (2009) 1.05
A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations. Genet Epidemiol (2014) 0.89
Statistical testing of shared genetic control for potentially related traits. Genet Epidemiol (2013) 0.87
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet (2015) 2.04
Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat Commun (2015) 1.31
Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci. Nat Commun (2015) 1.18