Published in Nat Rev Genet on February 15, 2016
Network biology concepts in complex disease comorbidities. Nat Rev Genet (2016) 0.82
Genetic variation in MHC proteins is associated with T cell receptor expression biases. Nat Genet (2016) 0.82
The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. Nat Rev Immunol (2016) 0.80
Association of CD40 Gene Polymorphisms with Susceptibility to Neuromyelitis Optica Spectrum Disorders. Mol Neurobiol (2016) 0.78
The multiple pathways to autoimmunity. Nat Immunol (2017) 0.76
DNA-reactive B cells in lupus. Curr Opin Immunol (2016) 0.76
The Clinical Challenge of Autoimmune Psychosis: Learning from Anti-NMDA Receptor Autoantibodies. Front Psychiatry (2017) 0.75
Connecting genetic risk to disease end points through the human blood plasma proteome. Nat Commun (2017) 0.75
Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease. PLoS Genet (2017) 0.75
XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits. Genome Med (2016) 0.75
Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus. Immunol Lett (2016) 0.75
Immunogenomic approaches to understand the function of immune disease variants. Immunology (2017) 0.75
Helminth Immunomodulation in Autoimmune Disease. Front Immunol (2017) 0.75
Genomics and epigenomics in rheumatic diseases: what do they provide in terms of diagnosis and disease management? Clin Rheumatol (2017) 0.75
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy. PLoS One (2017) 0.75
Finding the missing heritability of complex diseases. Nature (2009) 67.95
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Population genomics of human gene expression. Nat Genet (2007) 24.49
Understanding mechanisms underlying human gene expression variation with RNA sequencing. Nature (2010) 16.86
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Transcriptome genetics using second generation sequencing in a Caucasian population. Nature (2010) 14.85
RNA-programmed genome editing in human cells. Elife (2013) 14.82
A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet (2014) 14.56
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Evolving concepts of rheumatoid arthritis. Nature (2003) 14.31
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum (1987) 14.21
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet (2004) 12.25
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32
Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science (2015) 9.92
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (2010) 9.61
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Intracellular pattern recognition receptors in the host response. Nature (2006) 8.04
Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med (1978) 7.97
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50
The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol (2008) 7.23
Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet (2013) 7.13
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61
An atlas of active enhancers across human cell types and tissues. Nature (2014) 6.57
Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature (2013) 6.57
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20
Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium. Nature (1999) 6.07
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Targeted data extraction of the MS/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis. Mol Cell Proteomics (2012) 5.95
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet (2011) 5.58
Promise and pitfalls of the Immunochip. Arthritis Res Ther (2011) 5.38
Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature (2014) 5.22
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet (2012) 5.11
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet (2005) 5.00
A statistical method for predicting classical HLA alleles from SNP data. Am J Hum Genet (2008) 4.65
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet (2004) 4.46
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nat Med (2006) 4.41
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet (1996) 4.33
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
A prescription for human immunology. Immunity (2008) 4.09
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
Genetic analysis of autoimmune disease. Cell (1996) 3.87
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81
Standardizing immunophenotyping for the Human Immunology Project. Nat Rev Immunol (2012) 3.81
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet (2012) 3.77
Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet (2012) 3.67
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet (1996) 3.37
Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet (2002) 3.30
Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res (2000) 3.27
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science (2014) 3.16
Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol (2008) 3.14
A deep profiler's guide to cytometry. Trends Immunol (2012) 3.14
Identification of genetic variants that affect histone modifications in human cells. Science (2013) 3.11
Variation in the human immune system is largely driven by non-heritable influences. Cell (2015) 3.07
Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One (2013) 3.07
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A (2013) 2.93
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet (2014) 2.88
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet (2013) 2.85
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85
Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol (2005) 2.83
Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet (2006) 2.80
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (2014) 2.77
Individualized medicine from prewomb to tomb. Cell (2014) 2.76
Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med (1995) 2.75
Passive and active DNA methylation and the interplay with genetic variation in gene regulation. Elife (2013) 2.70
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription. Science (2013) 2.66
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (2014) 2.63
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet (2015) 2.59
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med (2009) 2.55
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (2011) 2.54
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet (2014) 2.53
Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci U S A (2003) 2.50
The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. J Clin Endocrinol Metab (2004) 2.44
Functional annotation of noncoding sequence variants. Nat Methods (2014) 2.41
Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun (2009) 2.37