Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.

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Published in Nat Rev Mol Cell Biol on March 01, 2010

Authors

Mary Ellen Moynahan1, Maria Jasin

Author Affiliations

1: Developmental Biology Program, New York, New York 10065, USA.

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Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell Rep (2013) 1.07

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet (2011) 1.02

Loss of 53BP1 is a gain for BRCA1 mutant cells. Cancer Cell (2010) 1.01

RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) (2012) 1.00

Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol (2004) 0.98

Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96

Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair. J Biol Chem (2007) 0.95

Homologous recombination assay for interstrand cross-link repair. Methods Mol Biol (2011) 0.95

Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-x(L). Cancer Res (2002) 0.94

Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome. Proc Natl Acad Sci U S A (2007) 0.93

Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line. DNA Repair (Amst) (2005) 0.91

Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases. J Natl Cancer Inst Monogr (2008) 0.91

The tricky path to recombining X and Y chromosomes in meiosis. Ann N Y Acad Sci (2012) 0.90

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res (2013) 0.90

p21 promotes error-free replication-coupled DNA double-strand break repair. Nucleic Acids Res (2012) 0.89

Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. PLoS One (2012) 0.89

Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells. PLoS Genet (2011) 0.88

Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching. Eur J Immunol (2002) 0.87

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. Cancer Genet Cytogenet (2010) 0.86

DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested. Cell Cycle (2011) 0.86

Isolation of meiotic recombinants from mouse sperm. Methods Mol Biol (2011) 0.86

Preaching about the converted: how meiotic gene conversion influences genomic diversity. Ann N Y Acad Sci (2012) 0.85

Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex. Nucleic Acids Res (2012) 0.85

Attenuating homologous recombination stimulates an AID-induced antileukemic effect. J Exp Med (2013) 0.85

Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo. Mol Immunol (2008) 0.85

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS Genet (2013) 0.84

RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability. Neuro Oncol (2011) 0.82

53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma. Cancer Res (2012) 0.82

How much is enough? Control of DNA double-strand break numbers in mouse meiosis. Cell Cycle (2013) 0.80

Analysis of recombinants in female mouse meiosis. Methods Mol Biol (2013) 0.76

Seeking new meiotic genes. Proc Natl Acad Sci U S A (2003) 0.76

Immunology. Antibodies get a break. Science (2006) 0.75

Measuring recombination proficiency in mouse embryonic stem cells. Methods Mol Biol (2014) 0.75