Human telomeres contain at least three types of G-rich repeat distributed non-randomly.

PubWeight™: 4.72‹?› | Rank: Top 1%

🔗 View Article (PMC 318019)

Published in Nucleic Acids Res on June 26, 1989

Authors

R C Allshire1, M Dempster, N D Hastie

Author Affiliations

1: MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

Articles citing this

Telomere measurement by quantitative PCR. Nucleic Acids Res (2002) 18.69

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97

Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19

Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18

Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J (1995) 6.03

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet (1993) 4.78

Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci U S A (1994) 3.86

Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell (2008) 3.24

Human telomeres are attached to the nuclear matrix. EMBO J (1992) 3.08

Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol (2008) 2.85

The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics (1994) 2.70

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol (1994) 2.57

Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res (1990) 2.56

Origin of human chromosome 2: an ancestral telomere-telomere fusion. Proc Natl Acad Sci U S A (1991) 2.54

Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol Psychiatry (2012) 2.37

Identification of a nonprocessive telomerase activity from mouse cells. Proc Natl Acad Sci U S A (1993) 2.24

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence. Nucleic Acids Res (2007) 2.23

Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n. Nucleic Acids Res (1990) 2.23

Unusual chromatin in human telomeres. Mol Cell Biol (1994) 2.19

A mammalian factor that binds telomeric TTAGGG repeats in vitro. Mol Cell Biol (1992) 2.04

Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining. Am J Pathol (2002) 1.95

Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92

Polymorphism of human telomeric quadruplex structures. Biochimie (2008) 1.89

Perfect endings: a review of subtelomeric probes and their use in clinical diagnosis. J Med Genet (2000) 1.86

Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation. Nucleic Acids Res (2007) 1.72

Modification of subtelomeric DNA. Mol Cell Biol (2004) 1.60

Pinning down loose ends: mapping telomeres and factors affecting their length. Plant Cell (1992) 1.59

The effect of TERC haploinsufficiency on the inheritance of telomere length. Proc Natl Acad Sci U S A (2005) 1.56

Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56

The structure of a subterminal repeated sequence present on many human chromosomes. Nucleic Acids Res (1990) 1.53

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol (1996) 1.44

Identification of a pentanucleotide telomeric sequence, (TTAGG)n, in the silkworm Bombyx mori and in other insects. Mol Cell Biol (1993) 1.42

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures. Nucleic Acids Res (2009) 1.25

In situ analysis of changes in telomere size during replicative aging and cell transformation. J Cell Biol (1996) 1.23

Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. EMBO J (1995) 1.23

Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic biology. Bioessays (2012) 1.23

Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol Cell Biol (1999) 1.19

Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19

Characterization of terminal deletions at 7q32 and 22q13.3 healed by De novo telomere addition. Am J Hum Genet (2000) 1.17

Macrostructure of the tomato telomeres. Plant Cell (1991) 1.12

Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. EMBO Rep (2003) 1.12

Beyond average: potential for measurement of short telomeres. Aging (Albany NY) (2012) 1.12

Direct comparison of flow-FISH and qPCR as diagnostic tests for telomere length measurement in humans. PLoS One (2014) 1.11

High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution. Am J Hum Genet (2000) 1.08

A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One (2008) 1.08

Characterization of Arabidopsis thaliana telomeres isolated in yeast. Nucleic Acids Res (1992) 1.07

Similarities and differences between "uncapped" telomeres and DNA double-strand breaks. Chromosoma (2011) 1.05

Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome. Nucleic Acids Res (2013) 1.04

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. J Cell Biol (2012) 1.02

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad. Nucleic Acids Res (2009) 1.02

Alternative lengthening of telomeres: remodeling the telomere architecture. Front Oncol (2013) 1.00

Natural variation in a subtelomeric region of Arabidopsis: implications for the genomic dynamics of a chromosome end. Genetics (2006) 0.97

Human telomerase activity regulation. Mol Biol Rep (2010) 0.94

Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity. Nucleic Acids Res (2013) 0.94

Structural and transcriptional analysis of a human subtelomeric repeat. Nucleic Acids Res (1991) 0.94

Analysis of Carica papaya Telomeres and Telomere-Associated Proteins: Insights into the Evolution of Telomere Maintenance in Brassicales. Trop Plant Biol (2008) 0.88

Intranuclear anchoring of repetitive DNA sequences: centromeres, telomeres, and ribosomal DNA. J Cell Biol (1999) 0.87

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline. Nucleic Acids Res (2009) 0.87

Telomere length: a review of methods for measurement. Nurs Res (2014) 0.86

Unwinding protein complexes in ALTernative telomere maintenance. J Cell Biochem (2010) 0.86

Telomere length is associated with types of chromosome 21 nondisjunction: a new insight into the maternal age effect on Down syndrome birth. Hum Genet (2010) 0.86

Telomeres and human reproduction. Fertil Steril (2013) 0.86

No association between mean telomere length and life stress observed in a 30 year birth cohort. PLoS One (2014) 0.85

Robust measurement of telomere length in single cells. Proc Natl Acad Sci U S A (2013) 0.85

Clinical significance of telomerase and its associate genes expression in the maintenance of telomere length in squamous cell carcinoma of the esophagus. World J Gastroenterol (2005) 0.85

Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. Stem Cells Dev (2014) 0.84

TCAGG, an alternative telomeric sequence in insects. Chromosoma (2011) 0.84

PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. J Cell Mol Med (2009) 0.84

Telomere maintenance mechanisms in cancer: clinical implications. Curr Pharm Des (2014) 0.82

Targeting different types of human meningioma and glioma cells using a novel adenoviral vector expressing GFP-TRAIL fusion protein from hTERT promoter. Cancer Cell Int (2011) 0.81

Meiotic instability of chicken ultra-long telomeres and mapping of a 2.8 megabase array to the W-sex chromosome. Chromosome Res (2005) 0.81

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Res (2013) 0.80

Telomere function in colorectal cancer. World J Gastrointest Oncol (2009) 0.79

In vitro and in vivo reconstitution and stability of vertebrate chromosome ends. Nucleic Acids Res (1998) 0.79

Molecular cytogenetics investigation of the telomeres in a case of Philadelphia positive B-ALL with a single telomere expansion. Neoplasia (1999) 0.78

Aloe spp.--plants with vertebrate-like telomeric sequences. Chromosome Res (2002) 0.77

Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells. PLoS One (2014) 0.77

Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops. PLoS One (2013) 0.77

Extracting extra-telomeric phenotypes from telomerase mouse models. Yonsei Med J (2014) 0.76

Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scrambling. PLoS Genet (2012) 0.75

Telomerase activation and human papillomavirus infection in invasive uterine cervical carcinoma in a set of Malaysian patients. J Clin Pathol (2002) 0.75

Characterization of a herpes simplex virus sequence which binds a cellular protein as either a single-stranded or double-stranded DNA or RNA. J Virol (1992) 0.75

A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi. Microbiol Spectr (2017) 0.75

Telomeres and telomerase in prostate cancer development and therapy. Nat Rev Urol (2017) 0.75

Articles cited by this

Genomic sequencing. Proc Natl Acad Sci U S A (1984) 92.36

Isolation of high-molecular-weight DNA from mammalian cells. Eur J Biochem (1973) 24.38

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (1989) 13.18

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A (1988) 11.81

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature (1988) 8.58

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32

The molecular structure of centromeres and telomeres. Annu Rev Biochem (1984) 7.51

DNA sequences of telomeres maintained in yeast. Nature (1984) 6.52

Isolation of a higher eukaryotic telomere from Arabidopsis thaliana. Cell (1988) 4.86

Base sequence and evolution of guinea-pig alpha-satellite DNA. Nature (1970) 4.19

Three-dimensional architecture of a polytene nucleus. Nature (1983) 3.82

Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature (1988) 3.20

Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harb Symp Quant Biol (1986) 3.17

Recombination occurs during telomere formation in yeast. Nature (1989) 2.89

An intervening sequence in the gene coding for 25S ribosomal RNA of Tetrahymena pigmentosa. Cell (1979) 2.69

Molecular cloning of human telomeres in yeast. Nature (1989) 2.67

Cloning of human telomeres by complementation in yeast. Nature (1989) 2.67

Dynamics of telomere length variation in Tetrahymena thermophila. Cell (1987) 2.56

Is there left-handed DNA at the ends of yeast chromosomes? Nature (1983) 2.49

Developmentally controlled telomere addition in wild-type and mutant paramecia. Mol Cell Biol (1988) 2.41

Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1988) 2.32

Nucleotide sequences of HS-alpha satellite DNA from kangaroo rat Dipodomys ordii and characterization of similar sequences in other rodents. Cell (1977) 2.00

Universal restriction endonucleases: designing novel cleavage specificities by combining adapter oligodeoxynucleotide and enzyme moieties. Gene (1985) 1.85

Identification of a telomeric DNA sequence in Plasmodium berghei. EMBO J (1985) 1.78

Restriction enzymes and their isoschizomers. Nucleic Acids Res (1987) 1.65

Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum polycephalum. Nucleic Acids Res (1987) 1.62

Automatic reading of DNA sequencing gel autoradiographs using a large format digital scanner. Nucleic Acids Res (1986) 1.54

Telomeric site position heterogeneity in macronuclear DNA of Paramecium primaurelia. Nucleic Acids Res (1987) 1.45

Sequence and hairpin structure of an inverted repeat series at termini of the Physarum extrachromosomal rDNA molecule. Cell (1983) 1.05

Similarity of satilite DNA properties in the order Rodentia. Nucleic Acids Res (1977) 0.94

The use of cloned Y chromosome-specific DNA probes for fetal sex determination in first trimester prenatal diagnosis. Hum Genet (1984) 0.91

Articles by these authors

(truncated to the top 100)

Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24

Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature (1992) 6.32

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature (1998) 6.29

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region. Cell (1991) 5.84

The expression of three abundance classes of messenger RNA in mouse tissues. Cell (1976) 5.58

Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature (1988) 3.20

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell (1996) 3.01

YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development (1999) 2.71

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell (1995) 2.63

Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res (1990) 2.56

Multiple genes coding for the androgen-regulated major urinary proteins of the mouse. Cell (1979) 2.52

Accelerated evolution in the reactive centre regions of serine protease inhibitors. Nature (1987) 2.40

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Nature (1993) 2.26

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev (1993) 2.26

Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. EMBO J (1984) 2.09

The gene family for major urinary proteins: expression in several secretory tissues of the mouse. Cell (1983) 2.09

Most highly repeated dispersed DNA families in the mouse genome. Mol Cell Biol (1984) 2.04

Analysis of mRNA populations by cDNA.mRNA hybrid-mediated inhibition of cell-free protein synthesis. Proc Natl Acad Sci U S A (1978) 1.92

Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript. Science (1992) 1.71

A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition. J Biol Chem (1996) 1.70

Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice. Proc Natl Acad Sci U S A (2001) 1.69

Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches. Ann Hum Genet (2006) 1.68

Developmentally regulated mRNAs in mouse liver. Proc Natl Acad Sci U S A (1982) 1.66

Mapping the structural genes coding for the major urinary proteins in the mouse: combined use of recombinant inbred strains and somatic cell hybrids. Proc Natl Acad Sci U S A (1982) 1.60

A fission yeast chromosome can replicate autonomously in mouse cells. Cell (1987) 1.60

Human telomeres: fusion and interstitial sites. Trends Genet (1989) 1.58

YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb. Mech Dev (1998) 1.54

The challenge of patients' unmet palliative care needs in the final stages of chronic illness. Palliat Med (2007) 1.54

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev (1998) 1.50

Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours. Oncogene (1992) 1.50

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions. Nature (1984) 1.48

Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. Dev Biol (2007) 1.47

Inhibition of influenza virus replication by -amanitin: mode of action. Proc Natl Acad Sci U S A (1972) 1.39

Heterogeneity analysis in 40 X-linked retinitis pigmentosa families. Am J Hum Genet (1994) 1.38

Cross-talk in kidney development. Curr Opin Genet Dev (2000) 1.38

Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene. Hum Genet (1996) 1.36

Construction of a small Mus musculus repetitive DNA library: identification of a new satellite sequence in Mus musculus. Nucleic Acids Res (1983) 1.36

RNA binding by the Wilms tumor suppressor zinc finger proteins. Proc Natl Acad Sci U S A (1996) 1.27

Zinc finger point mutations within the WT1 gene in Wilms tumor patients. Proc Natl Acad Sci U S A (1992) 1.26

Hybridization of nuclear matrix attached deoxyribonucleic acid fragments. Biochemistry (1981) 1.26

A genetic locus closely linked to a protease inhibitor gene complex controls the level of multiple RNA transcripts. Mol Cell Biol (1985) 1.24

Molecular and physical arrangements of human DNA in HRAS1-selected, chromosome-mediated transfectants. Mol Cell Biol (1986) 1.17

No homology between double-stranded RNA and nuclear DNA of yeast. J Virol (1978) 1.15

Identification of WTAP, a novel Wilms' tumour 1-associating protein. Hum Mol Genet (2000) 1.12

Wilms' tumour: reconciling genetics and biology. Trends Genet (1992) 1.12

An abundant androgen-regulated mRNA in the mouse kidney. Cell (1979) 1.11

Identification of a cDNA clone for mouse apoprotein A-1 (apo A-1) and its use in characterization of apo A-1 mRNA expression in liver and small intestine. Proc Natl Acad Sci U S A (1983) 1.10

Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol (2011) 1.10

Extent of linkage disequilibrium in a Sardinian sub-isolate: sampling and methodological considerations. Hum Mol Genet (2003) 1.08

The evolution of WT1 sequence and expression pattern in the vertebrates. Oncogene (1995) 1.08

Looking for relationships between the most repeated dispersed DNA sequences in the mouse: small R elements are found associated consistently with long MIF repeats. EMBO J (1984) 1.07

Linkage relationships between X-linked retinitis pigmentosa and nine short-arm markers: exclusion of the disease locus from Xp21 and localization to between DXS7 and DXS14. Am J Hum Genet (1987) 1.03

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Biochem J (1988) 1.03

A molecular genetic linkage map of mouse chromosome 2. Genomics (1990) 1.00

DNA-RNA hybridization. Philos Trans R Soc Lond B Biol Sci (1975) 0.99

Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion. Hum Mol Genet (1993) 0.99

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10. Am J Hum Genet (1988) 0.98

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A (1999) 0.98

Unusual chromosome structure of fission yeast DNA in mouse cells. J Cell Sci (1994) 0.97

Genetic linkage between X-linked retinitis pigmentosa and DNA probe DXS7 (L1.28): further linkage data, heterogeneity testing, and risk estimation. Hum Genet (1986) 0.97

Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein. J Biol Chem (1999) 0.94

Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers. Nucleic Acids Res (1988) 0.93

Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour. Nat Genet (1998) 0.93

Complex genetic diseases: controversy over the Croesus code. Genome Biol (2001) 0.92

Use of repetitive DNA sequences to distinguish Mus musculus and Mus caroli cells by in situ hybridization. J Embryol Exp Morphol (1983) 0.90

Studies of genetic linkage between adult polycystic kidney disease and three markers on chromosome 16. J Med Genet (1987) 0.89

20-hydroxyecdysone stimulates tissue-specific yolk-protein gene transcription in both male and female Drosophila. J Embryol Exp Morphol (1983) 0.89

Inherited Creutzfeldt-Jakob disease in a British family associated with a novel 144 base pair insertion of the prion protein gene. J Neurol Neurosurg Psychiatry (1995) 0.88

Regulation of the Wilms' tumor gene during spermatogenesis. Dev Dyn (1996) 0.87

CpG islands surround a DNA segment located between translocation breakpoints associated with genitourinary dysplasia and aniridia. Genomics (1989) 0.87

The adaptations of a quality of life questionnaire for routine use in clinical practice: the Chronic Respiratory Disease Questionnaire in cystic fibrosis. Qual Life Res (1999) 0.87

RNA-dependent RNA polymerase in nuclei of cells infected with influenza virus. J Virol (1973) 0.86

Does the Wilms' tumour suppressor gene, WT1, play roles in both splicing and transcription? J Cell Sci Suppl (1995) 0.86

Expression of the yolk-protein genes in the mutant doublesex dominant (dsxD) of Drosophila melanogaster. J Embryol Exp Morphol (1983) 0.84

Wilms' tumour as a paradigm for the relationship of cancer to development. Cancer Surv (1990) 0.84

Analysis of WAGR deletions and related translocations with gene-specific DNA probes, using FACS-selected cell hybrids. Somat Cell Mol Genet (1988) 0.83

Effects of -amanitin in vivo on RNA polymerase activity of cultured chick embryo fibroblast cell nuclei: resistance of ribosomal RNA synthesis to the drug. FEBS Lett (1973) 0.83

Wilms' tumour--a case of disrupted development. J Cell Sci Suppl (1994) 0.83

Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression. Genes Chromosomes Cancer (1995) 0.82

Mechanism of endonuclease banding of chromosomes. Exp Cell Res (1984) 0.82

A genetic linkage study of choroideremia. Ophthalmic Paediatr Genet (1986) 0.82

Patient anxiety and IV sedation in Northern Ireland. Br Dent J (2011) 0.81

The Wilms' tumor suppressor WT1: approaches to gene function. Kidney Int (1998) 0.81

Do people with diabetes who need to talk want to talk? Diabet Med (2006) 0.81

Repression of promoters for the mouse insulin-like growth factor II-encoding gene (Igf-2) by products of the Wilms' tumour suppressor gene wt1. Gene (1995) 0.80

Did nucleotides or amino acids drive evolutionary conservation of the WT1 +/-KTS alternative splice? Hum Mol Genet (2000) 0.80

A candidate marsupial PrP gene reveals two domains conserved in mammalian PrP proteins. Gene (1995) 0.79

The regulation of yolk protein gene expression in Drosophila melanogaster. Ciba Found Symp (1983) 0.79

Characterisation of a new tumorous-head mutant of Drosophila melanogaster. Mol Gen Genet (1981) 0.79

Sexing the human pre-embryo by DNA-DNA in-situ hybridisation. Lancet (1987) 0.79

Mouse Small eye results from mutations in a paired-like homeobox-containing gene. Nature (1992) 0.78

Nonclinical aspects of biopharmaceutical development: discussion of case studies at a PhRMA-FDA workshop. Int J Toxicol (2008) 0.78

Linkage heterogeneity and fragile X. Hum Genet (1988) 0.77

Self-perception in overweight and obese children: a cross-sectional study. Child Care Health Dev (2009) 0.77

Gonadal effects of a mouse Denys-Drash syndrome mutation. Transgenic Res (2005) 0.77

Aniridia, Wilms' tumor and human chromosome 11. Ophthalmic Paediatr Genet (1989) 0.77

Neuropathological phenotype and 'prion protein' genotype correlation in sporadic Creutzfeldt-Jakob disease. Neurosci Lett (1994) 0.76

A mouse homeo box-containing gene maps near a developmental mutation. Cytogenet Cell Genet (1987) 0.76

Familial Alzheimer's disease. Beta amyloid resurrected. Nature (1991) 0.75

Changes to basic life support guidelines--evidence-based practice? Resuscitation (2001) 0.75