Perspectives in Polycystic Ovary Syndrome: From Hair to Eternity.

PubWeight™: 0.81‹?›

🔗 View Article (PMID 26908109)

Published in J Clin Endocrinol Metab on February 23, 2016

Authors

Andrea Dunaif1

Author Affiliations

1: Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.

Articles cited by this

(truncated to the top 100)

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

A haplotype map of the human genome. Nature (2005) 105.70

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79

A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc (2009) 38.62

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97

Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94

Genetic dissection of complex traits. Science (1994) 29.54

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (2004) 21.65

Common genetic variation and human traits. N Engl J Med (2009) 21.03

Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12

MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods (2010) 16.61

A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet (2014) 14.56

Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47

Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet (2005) 12.12

Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res (2011) 10.99

Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet (2010) 9.53

The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20

Genomewide association studies--illuminating biologic pathways. N Engl J Med (2009) 8.83

Role of brain insulin receptor in control of body weight and reproduction. Science (2000) 8.14

Inference of human population history from individual whole-genome sequences. Nature (2011) 8.05

Discerning the ancestry of European Americans in genetic association studies. PLoS Genet (2007) 7.81

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet (2010) 7.08

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med (2015) 6.48

Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85

Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39

Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet (2011) 3.73

Predicting the functional, molecular, and phenotypic consequences of amino acid substitutions using hidden Markov models. Hum Mutat (2012) 3.60

New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38

Genome-wide significance for dense SNP and resequencing data. Genet Epidemiol (2008) 3.26

Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet (2007) 3.13

Bayesian inference of ancient human demography from individual genome sequences. Nat Genet (2011) 3.03

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet (2010) 3.02

Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci U S A (1998) 2.86

Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80

Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol (2006) 2.70

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2013) 2.43

DNA analysis of an early modern human from Tianyuan Cave, China. Proc Natl Acad Sci U S A (2013) 2.31

Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12

Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2009) 2.08

Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet (2012) 2.02

Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab (1980) 1.91

Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2. J Clin Endocrinol Metab (2005) 1.84

Observations on the polycystic ovary syndrome. Am J Obstet Gynecol (1957) 1.81

Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. Genet Epidemiol (2011) 1.78

Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update (2008) 1.77

Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Natl Acad Sci U S A (1999) 1.68

Heritability of polycystic ovary syndrome in a Dutch twin-family study. J Clin Endocrinol Metab (2005) 1.64

Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci U S A (1995) 1.64

Mutations in the insulin receptor gene. Endocr Rev (1992) 1.55

Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet (2010) 1.52

Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts. J Med Genet (2011) 1.51

The PCSK9 decade. J Lipid Res (2012) 1.50

Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab (2012) 1.44

Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome. Proc Natl Acad Sci U S A (2006) 1.38

Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype. J Clin Endocrinol Metab (2007) 1.37

Reducing LDL with PCSK9 Inhibitors--The Clinical Benefit of Lipid Drugs. N Engl J Med (2015) 1.34

Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity. J Clin Endocrinol Metab (2006) 1.31

Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype. Proc Natl Acad Sci U S A (2014) 1.28

Glucose intolerance, insulin resistance, and hyperandrogenemia in first degree relatives of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2003) 1.27

The genetics of the polycystic ovary syndrome. Nat Clin Pract Endocrinol Metab (2007) 1.26

Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol (2011) 1.25

Genome-wide association studies and type 2 diabetes. Brief Funct Genomics (2011) 1.24

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc Natl Acad Sci U S A (2014) 1.21

Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome. Metabolism (2008) 1.20

Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry. J Clin Endocrinol Metab (2012) 1.19

Hereditary factors in the Stein-Leventhal syndrome. Am J Obstet Gynecol (1968) 1.16

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun (2015) 1.14

Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2002) 1.12

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia (2008) 1.12

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J Endocrinol (2014) 1.10

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nat Commun (2015) 1.09

Renaming PCOS--a two-state solution. J Clin Endocrinol Metab (2013) 1.08

Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome. J Clin Endocrinol Metab (2013) 1.07

Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome. Diabetologia (2002) 1.07

Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus. J Clin Endocrinol Metab (2001) 1.05

Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels. J Clin Endocrinol Metab (2010) 1.04

Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes. J Clin Invest (2011) 1.03

Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome. J Clin Endocrinol Metab (2006) 1.01

Epigenetics in polycystic ovary syndrome: a pilot study of global DNA methylation. Fertil Steril (2009) 1.01

Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys. PLoS One (2011) 1.00

Polycystic ovary syndrome: an ancient disorder? Fertil Steril (2010) 0.99

The transmission/disequilibrium test detects cosegregation and linkage. Am J Hum Genet (1994) 0.99

Genetics of the polycystic ovary syndrome. Mol Cell Endocrinol (2012) 0.97

Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes (2013) 0.97

High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity. J Clin Endocrinol Metab (2009) 0.95

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort. Genome Res (2015) 0.94

Effects of increasing the frequency of low doses of gonadotropin-releasing hormone (GnRH) on gonadotropin secretion in GnRH-deficient men. J Clin Endocrinol Metab (1987) 0.94

Hypomethylation of the LH/choriogonadotropin receptor promoter region is a potential mechanism underlying susceptibility to polycystic ovary syndrome. Endocrinology (2014) 0.92

Nonhuman primate models of polycystic ovary syndrome. Mol Cell Endocrinol (2013) 0.91