Published in Nat Rev Genet on February 01, 2005
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Mapping determinants of human gene expression by regional and genome-wide association. Nature (2005) 17.24
SNP detection for massively parallel whole-genome resequencing. Genome Res (2009) 15.96
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Genetic diagnosis by whole exome capture and massively parallel DNA sequencing. Proc Natl Acad Sci U S A (2009) 15.09
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genomewide association studies and human disease. N Engl J Med (2009) 9.05
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet (2005) 6.86
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61
Predicting quantitative traits with regression models for dense molecular markers and pedigree. Genetics (2009) 5.18
Genetic design and statistical power of nested association mapping in maize. Genetics (2008) 4.92
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Bioinformatics challenges for genome-wide association studies. Bioinformatics (2010) 4.45
Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. Am J Hum Genet (2006) 4.40
Bayesian statistical methods for genetic association studies. Nat Rev Genet (2009) 4.37
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
A Bayesian measure of the probability of false discovery in genetic epidemiology studies. Am J Hum Genet (2007) 4.21
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet (2005) 3.76
Missing data imputation and haplotype phase inference for genome-wide association studies. Hum Genet (2008) 3.65
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet (2007) 3.31
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies. Nat Genet (2009) 3.06
Perspectives on human genetic variation from the HapMap Project. PLoS Genet (2005) 2.91
Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Mol Psychiatry (2007) 2.85
Plasma lipoproteins: genetic influences and clinical implications. Nat Rev Genet (2009) 2.80
Linkage and association mapping of Arabidopsis thaliana flowering time in nature. PLoS Genet (2010) 2.76
Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One (2009) 2.72
Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come. Am J Hum Genet (2010) 2.64
Machine learning for detecting gene-gene interactions: a review. Appl Bioinformatics (2006) 2.56
Transethnic meta-analysis of genomewide association studies. Genet Epidemiol (2011) 2.53
A high-density screen for linkage in multiple sclerosis. Am J Hum Genet (2005) 2.50
The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev (2011) 2.44
What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet (2008) 2.35
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull (2008) 2.35
Methodological challenges of genome-wide association analysis in Africa. Nat Rev Genet (2010) 2.27
Discovering genetic associations with high-dimensional neuroimaging phenotypes: A sparse reduced-rank regression approach. Neuroimage (2010) 2.27
Biases and reconciliation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet (2006) 2.26
TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia (2007) 2.22
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22
Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. Am J Psychiatry (2012) 2.20
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Med Genomics (2008) 2.20
Estimating odds ratios in genome scans: an approximate conditional likelihood approach. Am J Hum Genet (2008) 2.12
GSA-SNP: a general approach for gene set analysis of polymorphisms. Nucleic Acids Res (2010) 2.09
HaploRec: efficient and accurate large-scale reconstruction of haplotypes. BMC Bioinformatics (2006) 2.08
Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes Brain Behav (2008) 2.08
Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. PLoS Genet (2006) 2.02
Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances. Nucleic Acids Res (2009) 1.98
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet (2009) 1.93
Neurodevelopmental hypothesis of schizophrenia. Br J Psychiatry (2011) 1.87
The Generation R Study: design and cohort update 2010. Eur J Epidemiol (2010) 1.85
Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster. Genetics (2007) 1.78
Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS. Bioinformatics (2010) 1.76
Towards a complete resolution of the genetic architecture of disease. Trends Genet (2010) 1.75
Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases. Hum Genet (2008) 1.72
Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. PLoS One (2007) 1.69
Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics (2011) 1.68
The complex genetics of multiple sclerosis: pitfalls and prospects. Brain (2008) 1.68
Bayesian graphical models for genomewide association studies. Am J Hum Genet (2006) 1.66
Fine mapping versus replication in whole-genome association studies. Am J Hum Genet (2007) 1.64
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63
Genome-wide analysis reveals a complex pattern of genomic imprinting in mice. PLoS Genet (2008) 1.63
Classifying severity of cystic fibrosis lung disease using longitudinal pulmonary function data. Am J Respir Crit Care Med (2006) 1.63
Sequencing multiple and diverse rice varieties. Connecting whole-genome variation with phenotypes. Plant Physiol (2006) 1.61
Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size. Genetics (2007) 1.60
Evaluating cost efficiency of SNP chips in genome-wide association studies. Genet Epidemiol (2008) 1.60
Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59
Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease. Nat Rev Neurosci (2012) 1.58
The 'common disease-common variant' hypothesis and familial risks. PLoS One (2008) 1.56
Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better? Lancet Infect Dis (2006) 1.56
The genetics of NAFLD. Nat Rev Gastroenterol Hepatol (2013) 1.55
Genetic causes of high and low serum HDL-cholesterol. J Lipid Res (2010) 1.55
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet (2008) 1.53
The effect of polymorphisms in the enhancer of split gene complex on bristle number variation in a large wild-caught cohort of Drosophila melanogaster. Genetics (2005) 1.52
Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. Neuroimage (2011) 1.48
Genome-wide association studies of cancer. J Clin Oncol (2010) 1.45
DNA sequence variation and selection of tag single-nucleotide polymorphisms at candidate genes for drought-stress response in Pinus taeda L. Genetics (2005) 1.44
Investigation of susceptibility genes triggering lachrymal/salivary gland lesion complications in Japanese patients with type 1 autoimmune pancreatitis. PLoS One (2015) 1.41
Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide association mapping. Genetics (2009) 1.41
Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. BMC Genomics (2016) 1.41
New virologic tools for management of chronic hepatitis B and C. Gastroenterology (2012) 1.41
Prioritized subset analysis: improving power in genome-wide association studies. Hum Hered (2007) 1.40
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies. Hum Genet (2012) 1.37
Drug resistance and genetic mapping in Plasmodium falciparum. Curr Genet (2008) 1.36
Enabling personal genomics with an explicit test of epistasis. Pac Symp Biocomput (2010) 1.33
Intraspecific variation of recombination rate in maize. Genome Biol (2013) 1.32
Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer. Hum Mol Genet (2012) 1.31
No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening. Am J Hum Genet (2006) 1.31
Quantifying the underestimation of relative risks from genome-wide association studies. PLoS Genet (2011) 1.30
Regions of homozygosity and their impact on complex diseases and traits. Hum Genet (2010) 1.30
From obesity genetics to the future of personalized obesity therapy. Nat Rev Endocrinol (2013) 1.29
Genomewide association, Parkinson disease, and PARK10. Am J Hum Genet (2006) 1.28
A note on permutation tests in multistage association scans. Am J Hum Genet (2006) 1.28
Nonmetric multidimensional scaling corrects for population structure in association mapping with different sample types. Genetics (2009) 1.25
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet (2001) 8.47
Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med (2012) 6.93
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med (2007) 6.47
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes (2004) 4.81
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet (2010) 3.50
Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol (2004) 3.39
Betting odds and genetic associations. J Natl Cancer Inst (2004) 3.39
Genetic association studies. Lancet (2005) 3.35
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res (2006) 3.25
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) (2007) 3.17
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes (2005) 2.85
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes (2008) 2.74
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet (2009) 2.38
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. PLoS One (2008) 2.28
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Circ Cardiovasc Genet (2012) 2.26
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet (2011) 2.25
The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci (2006) 2.22
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02
Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes (2004) 2.02
Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping. Am J Hum Genet (2006) 2.01
Metagenomics and personalized medicine. Cell (2011) 2.00
Parameters for reliable results in genetic association studies in common disease. Nat Genet (2002) 2.00
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol (2006) 1.79
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes (2011) 1.78
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics (2008) 1.72
Experimental aspects of copy number variant assays at CCL3L1. Nat Med (2009) 1.71
Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Res (2002) 1.68
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes (2007) 1.68
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab (2004) 1.60
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol (2004) 1.59
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci (2006) 1.56
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet (2004) 1.48
Regression mapping of association between the human leukocyte antigen region and Graves disease. Am J Hum Genet (2004) 1.47
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet (2013) 1.47
T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acids Res (2005) 1.44
SNP allele frequency estimation in DNA pools and variance components analysis. Biotechniques (2004) 1.44
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs. Diabetes (2011) 1.44
Copy number, linkage disequilibrium and disease association in the FCGR locus. Hum Mol Genet (2010) 1.41
Gene-gene interactions in the NOD mouse model of type 1 diabetes. Adv Immunol (2008) 1.39
Genetic analysis of autoimmune type 1 diabetes mellitus in mice. 1991. J Immunol (2014) 1.37
A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Hum Mol Genet (2007) 1.35
Type 1 diabetes genes and pathways shared by humans and NOD mice. J Autoimmun (2005) 1.34
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol (2012) 1.31
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30