Published in J Exp Neurosci on February 03, 2016
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors. Eye Vis (Lond) (2016) 0.78
Epigenetics and Signaling Pathways in Glaucoma. Biomed Res Int (2017) 0.75
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
The language of covalent histone modifications. Nature (2000) 44.92
10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med (2008) 35.49
Global data on visual impairment in the year 2002. Bull World Health Organ (2004) 28.05
The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol (2006) 25.47
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (2001) 23.83
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48
Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol (2004) 18.86
Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell (2002) 9.80
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev (2002) 8.78
Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care (2012) 7.83
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
Age-related macular degeneration. N Engl J Med (2008) 7.49
Lamin A-dependent nuclear defects in human aging. Science (2006) 6.71
The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol (2004) 6.53
Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell (2012) 6.50
The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology (1997) 6.47
Pioneer transcription factors: establishing competence for gene expression. Genes Dev (2011) 6.01
Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol (2004) 5.44
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect (2012) 4.89
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period. Eur J Hum Genet (2002) 4.33
Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26
An operational definition of epigenetics. Genes Dev (2009) 4.26
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev (2001) 4.25
Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95
Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev (2008) 3.93
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell (1990) 3.75
A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch Ophthalmol (2005) 3.74
Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci (1996) 3.69
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J (1998) 3.63
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One (2009) 3.41
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell (2007) 3.27
Elevated histone expression promotes life span extension. Mol Cell (2010) 3.09
The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol Cell Biol (2006) 2.93
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays (2004) 2.84
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature (2009) 2.83
The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences. Arch Ophthalmol (2005) 2.83
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab (2009) 2.76
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature (2010) 2.67
Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab (2012) 2.46
Mapping human epigenomes. Cell (2013) 2.44
DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum Mol Genet (2010) 2.33
Glaucoma is second leading cause of blindness globally. Bull World Health Organ (2004) 2.30
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24
Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet (2012) 2.20
Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res (2008) 2.14
In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. J Biol Chem (2004) 2.07
HIF1 and oxygen sensing in the brain. Nat Rev Neurosci (2004) 2.01
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet (2014) 1.94
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One (2010) 1.89
HDAC4 regulates neuronal survival in normal and diseased retinas. Science (2009) 1.86
The genetic and epigenetic basis of type 2 diabetes and obesity. Clin Pharmacol Ther (2012) 1.84
The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol (2010) 1.83
Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med (2009) 1.83
Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv Nutr (2012) 1.80
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics (2011) 1.76
DNA methylation map of human atherosclerosis. Circ Cardiovasc Genet (2014) 1.68
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest (2007) 1.65
Human body epigenome maps reveal noncanonical DNA methylation variation. Nature (2015) 1.63
The role of genomic imprinting in biology and disease: an expanding view. Nat Rev Genet (2014) 1.56
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes (2014) 1.55
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet (2015) 1.55
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes (2012) 1.54
Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch Ophthalmol (2004) 1.52
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol (2013) 1.52
Screening and prevention of diabetic blindness. Acta Ophthalmol Scand (2000) 1.51
A genome-wide methylation study on obesity: differential variability and differential methylation. Epigenetics (2013) 1.51
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia (2008) 1.50
Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48
Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol (2013) 1.48
The role of DNA methylation in mammalian development. Reprod Biomed Online (2011) 1.48
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics (2014) 1.47
Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster. Eur Heart J (2014) 1.47
Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes. Diabetes (2008) 1.46
Induction of DNA hypomethylation by tumor hypoxia. Epigenetics (2007) 1.45
Distinct epigenomic features in end-stage failing human hearts. Circulation (2011) 1.39
Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J Biol Chem (2006) 1.39
Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study. Diabetes (2013) 1.38
Oxidative stress in glaucoma: a burden of evidence. J Glaucoma (2007) 1.36
Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect (2014) 1.35
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy. Epigenetics (2011) 1.33
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep (2012) 1.28
Glaucoma risk factors observed in the Baltimore Eye Survey. Curr Opin Ophthalmol (1996) 1.28
Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci (2014) 1.27
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet (2015) 1.26
Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation. Hum Mol Genet (2015) 1.25
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. Hum Mol Genet (2013) 1.24
DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. Clin Epigenetics (2015) 1.24
Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med (2013) 1.23
Generation of an epigenetic signature by chronic hypoxia in prostate cells. Hum Mol Genet (2009) 1.21