Mapping human epigenomes.

Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32

Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature (2014) 5.22

The next-generation sequencing revolution and its impact on genomics. Cell (2013) 3.35

Immunogenetics. Chromatin state dynamics during blood formation. Science (2014) 2.99

Individualized medicine from prewomb to tomb. Cell (2014) 2.76

Super-resolution imaging reveals distinct chromatin folding for different epigenetic states. Nature (2016) 2.21

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state. Nat Biotechnol (2015) 2.03

Absence of a simple code: how transcription factors read the genome. Trends Biochem Sci (2014) 1.84

Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics. Cell Rep (2015) 1.54

Single-molecule decoding of combinatorially modified nucleosomes. Science (2016) 1.48

DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circ Res (2016) 1.44

Integrative analysis of haplotype-resolved epigenomes across human tissues. Nature (2015) 1.40

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature (2016) 1.25

Library construction for next-generation sequencing: overviews and challenges. Biotechniques (2014) 1.20

Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression. Mod Pathol (2014) 1.16

Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat Rev Genet (2016) 1.15

The landscape of accessible chromatin in mammalian preimplantation embryos. Nature (2016) 1.13

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet (2016) 1.06

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. Cell Rep (2015) 1.05

dbSUPER: a database of super-enhancers in mouse and human genome. Nucleic Acids Res (2015) 1.02

Predicting chromatin organization using histone marks. Genome Biol (2015) 0.99

Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome. Epigenetics Chromatin (2015) 0.99

Genetic basis of autoimmunity. J Clin Invest (2015) 0.96

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers. Genome Res (2015) 0.96

Epigenetic inheritance and the missing heritability. Hum Genomics (2015) 0.95

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity. Stem Cell Reports (2015) 0.95

The role of DNA methylation in directing the functional organization of the cancer epigenome. Genome Res (2015) 0.94

LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex. PLoS Pathog (2014) 0.94

Epigenetics across the human lifespan. Front Cell Dev Biol (2014) 0.93

Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol Rev (2014) 0.93

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Mol Cell (2015) 0.91

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proc Natl Acad Sci U S A (2015) 0.89

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo. Oncotarget (2015) 0.89

Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics (2015) 0.88

Strategies for fine-mapping complex traits. Hum Mol Genet (2015) 0.88

Inducible chromatin priming is associated with the establishment of immunological memory in T cells. EMBO J (2016) 0.87

Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution. Cell (2015) 0.87

Approaches for establishing the function of regulatory genetic variants involved in disease. Genome Med (2014) 0.87

Distinct and predictive histone lysine acetylation patterns at promoters, enhancers, and gene bodies. G3 (Bethesda) (2014) 0.86

Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nat Methods (2015) 0.86

Epigenetic mechanisms in schizophrenia. Dialogues Clin Neurosci (2014) 0.85

Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution. J Vis Exp (2015) 0.85

Super-enhancers: Asset management in immune cell genomes. Trends Immunol (2015) 0.84

Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention. Biomed Res Int (2015) 0.84

Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia. Oncotarget (2015) 0.84

Genetics of gene expression in immunity to infection. Curr Opin Immunol (2014) 0.84

Epigenomics of macrophages. Immunol Rev (2014) 0.84

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility. Asian J Androl (2015) 0.83

Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Res (2014) 0.83

Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health. Clin Epigenetics (2015) 0.83

Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes. Int J Mol Sci (2015) 0.82

Using the ENCODE Resource for Functional Annotation of Genetic Variants. Cold Spring Harb Protoc (2015) 0.82

Nutritional systems biology of type 2 diabetes. Genes Nutr (2015) 0.82

RVD2: an ultra-sensitive variant detection model for low-depth heterogeneous next-generation sequencing data. Bioinformatics (2015) 0.82

Reorganization of chromosome architecture in replicative cellular senescence. Sci Adv (2016) 0.81

Computational and experimental methods to decipher the epigenetic code. Front Genet (2014) 0.81

Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells. Genomics (2014) 0.80

De novo deciphering three-dimensional chromatin interaction and topological domains by wavelet transformation of epigenetic profiles. Nucleic Acids Res (2016) 0.80

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr Top Microbiol Immunol (2014) 0.80

BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol (2014) 0.80

RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Mol Cell (2016) 0.80

Epigenetic marks: regulators of livestock phenotypes and conceivable sources of missing variation in livestock improvement programs. Front Genet (2015) 0.79

Endocrine disrupters: the new players able to affect the epigenome. Front Cell Dev Biol (2015) 0.79

Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes. Nucleic Acids Res (2015) 0.79

Epigenetics in lung fibrosis: from pathobiology to treatment perspective. Curr Opin Pulm Med (2015) 0.79

Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biol (2016) 0.78

Cellular reprogramming for understanding and treating human disease. Front Cell Dev Biol (2014) 0.78

DNA methylation and cognitive aging. Oncotarget (2015) 0.78

Forward Individualized Medicine from Personal Genomes to Interactomes. Front Physiol (2015) 0.78

DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated? Front Genet (2015) 0.78

Epigenetic regulation of open chromatin in pluripotent stem cells. Transl Res (2014) 0.78

System level dynamics of post-translational modifications. Curr Opin Biotechnol (2014) 0.77

Spectacle: fast chromatin state annotation using spectral learning. Genome Biol (2015) 0.77

DNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures. Sci Rep (2015) 0.77

Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers. Nat Rev Mol Cell Biol (2016) 0.76

A Comprehensive Characterization of the Function of LincRNAs in Transcriptional Regulation Through Long-Range Chromatin Interactions. Sci Rep (2016) 0.76

The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration. PLoS One (2016) 0.76

Epigenetic Mechanisms of the Aging Human Retina. J Exp Neurosci (2016) 0.76

Elucidating Combinatorial Chromatin States at Single-Nucleosome Resolution. Mol Cell (2016) 0.76

Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states. Sci Rep (2014) 0.76

Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail (2014) 0.76

Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease. J Cell Physiol (2014) 0.76

motifDiverge: a model for assessing the statistical significance of gene regulatory motif divergence between two DNA sequences. Stat Interface (2015) 0.76

Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression. PLoS Genet (2016) 0.76

Epigenetic dynamics of monocyte-to-macrophage differentiation. Epigenetics Chromatin (2016) 0.76

Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation. BMC Genomics (2017) 0.76

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Mol Cell (2017) 0.76

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models. Stem Cells Int (2015) 0.75

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications. Stem Cell Reports (2017) 0.75

Publisher’s Note:Abstraction for data integration:Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction. Comput Biol Chem (2015) 0.75

Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischemic heart? Cardiovasc Res (2017) 0.75

DNA methylation: an epigenetic mark of cellular memory. Exp Mol Med (2017) 0.75

In silico identification of enhancers on the basis of a combination of transcription factor binding motif occurrences. Sci Rep (2016) 0.75

Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits. Int J Obes (Lond) (2016) 0.75

Computational epigenomics: challenges and opportunities. Front Genet (2015) 0.75

Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies. Am J Epidemiol (2015) 0.75

Techniques and Approaches to Genetic Analyses in Nephrological Disorders. J Pediatr Genet (2015) 0.75

Clinical applications of molecular genetic discoveries. Transl Res (2015) 0.75

Genetic and epigenetic regulation of intestinal fibrosis. United European Gastroenterol J (2016) 0.75

Chromatin Dynamics Regulate Mesenchymal Stem Cell Lineage Specification and Differentiation to Osteogenesis. Biochim Biophys Acta (2017) 0.75

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

The sequence of the human genome. Science (2001) 101.55

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

Genome-wide mapping of in vivo protein-DNA interactions. Science (2007) 64.92

Chromatin modifications and their function. Cell (2007) 55.98

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48

Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27

DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell (2008) 32.65

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41

Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83

Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78

The role of chromatin during transcription. Cell (2007) 26.48

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37

A high-resolution map of active promoters in the human genome. Nature (2005) 24.35

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00

Capturing chromosome conformation. Science (2002) 23.93

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72

International network of cancer genome projects. Nature (2010) 20.35

Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82

Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23

The mammalian epigenome. Cell (2007) 18.13

The accessible chromatin landscape of the human genome. Nature (2012) 16.86

High sensitivity mapping of methylated cytosines. Nucleic Acids Res (1994) 16.62

Genetical implications of the structure of deoxyribonucleic acid. Nature (1953) 16.01

High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93

Dynamic regulation of nucleosome positioning in the human genome. Cell (2008) 15.60

Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13

CTCF: master weaver of the genome. Cell (2009) 15.09

Genome-wide map of nucleosome acetylation and methylation in yeast. Cell (2005) 15.08

Genome-scale identification of nucleosome positions in S. cerevisiae. Science (2005) 15.04

Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29

A unique chromatin signature uncovers early developmental enhancers in humans. Nature (2010) 14.02

The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99

Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res (2006) 13.32

Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39

An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16

Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11

Genome regulation by long noncoding RNAs. Annu Rev Biochem (2012) 11.70

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol (2013) 11.58

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature (2008) 10.95

Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71

Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37

High density DNA methylation array with single CpG site resolution. Genomics (2011) 10.35

Architecture of the human regulatory network derived from ENCODE data. Nature (2012) 10.28

Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods (2010) 9.75

Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature (2012) 9.75

Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell (2013) 9.55

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature (2011) 9.33

The long-range interaction landscape of gene promoters. Nature (2012) 9.20

Initial impact of the sequencing of the human genome. Nature (2011) 9.18

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res (2012) 9.13

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99

DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74

A map of the cis-regulatory sequences in the mouse genome. Nature (2012) 8.74

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69

Controlling the double helix. Nature (2003) 8.61

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31

Lessons from the cancer genome. Cell (2013) 8.12

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10

Continuous base identification for single-molecule nanopore DNA sequencing. Nat Nanotechnol (2009) 8.09

A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Res (2008) 7.89

FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res (2006) 7.72

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43

An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09

DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 6.65

CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55

Nucleosome positioning and gene regulation: advances through genomics. Nat Rev Genet (2009) 6.50

Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell (2013) 6.37

Gene body-specific methylation on the active X chromosome. Science (2007) 6.33

Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell (2011) 6.29

DNase I sensitivity QTLs are a major determinant of human expression variation. Nature (2012) 6.17

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06

Central dogma of molecular biology. Nature (1970) 5.89

Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80

Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17

Molecular signals of epigenetic states. Science (2010) 4.81

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. Nucleic Acids Res (2010) 4.79

Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Nat Biotechnol (2011) 4.56

Massively parallel functional dissection of mammalian enhancers in vivo. Nat Biotechnol (2012) 4.51

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nat Rev Genet (2013) 4.38

A decade of 3C technologies: insights into nuclear organization. Genes Dev (2012) 4.25

Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22

Comparative epigenomic analysis of murine and human adipogenesis. Cell (2010) 4.08

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52

Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

A high-resolution map of active promoters in the human genome. Nature (2005) 24.35

ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38

Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23

Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66

The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94

Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74

A map of the cis-regulatory sequences in the mouse genome. Nature (2012) 8.74

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00

Genome-wide analysis of protein-DNA interactions. Annu Rev Genomics Hum Genet (2006) 6.47

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93

Next-generation genomics: an integrative approach. Nat Rev Genet (2010) 5.88

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27

A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18

A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80

ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32

An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08

Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell (2012) 4.00

Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81

An assessment of histone-modification antibody quality. Nat Struct Mol Biol (2010) 3.72

Direct isolation and identification of promoters in the human genome. Genome Res (2005) 3.68

Discovery and annotation of functional chromatin signatures in the human genome. PLoS Comput Biol (2009) 3.61

ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome. PLoS Comput Biol (2008) 3.46

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res (2011) 3.36

Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35

Predictive chromatin signatures in the mammalian genome. Hum Mol Genet (2009) 3.25

Finding distal regulatory elements in the human genome. Curr Opin Genet Dev (2009) 3.02

Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet (2011) 2.87

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells. Proc Natl Acad Sci U S A (2013) 2.71

Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat Genet (2013) 2.41

ChIP-chip: data, model, and analysis. Biometrics (2007) 2.27

Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem (2008) 2.17

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res (2007) 2.16

Fine tuning of craniofacial morphology by distant-acting enhancers. Science (2013) 2.16

Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet (2007) 2.08

Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing. Nat Biotechnol (2013) 2.05

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev (2011) 1.86

Genome-wide prediction of transcription factor binding sites using an integrated model. Genome Biol (2010) 1.84

HiCNorm: removing biases in Hi-C data via Poisson regression. Bioinformatics (2012) 1.77

Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72

The transcriptional regulatory code of eukaryotic cells--insights from genome-wide analysis of chromatin organization and transcription factor binding. Curr Opin Cell Biol (2006) 1.71

Genome-wide mapping of allele-specific protein-DNA interactions in human cells. Nat Methods (2008) 1.69

RFECS: a random-forest based algorithm for enhancer identification from chromatin state. PLoS Comput Biol (2013) 1.66

Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.66

Bayesian inference of spatial organizations of chromosomes. PLoS Comput Biol (2013) 1.66

Prediction of regulatory elements in mammalian genomes using chromatin signatures. BMC Bioinformatics (2008) 1.64

Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Elife (2013) 1.64

Genome organization and long-range regulation of gene expression by enhancers. Curr Opin Cell Biol (2013) 1.63

Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell (2008) 1.57

Transcription: Enhancers make non-coding RNA. Nature (2010) 1.54

PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers. Proc Natl Acad Sci U S A (2011) 1.30

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity (2013) 1.27

beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. Oncogene (2005) 1.21

Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II. Mol Cell (2012) 1.18

An integrated approach to identifying cis-regulatory modules in the human genome. PLoS One (2009) 1.16

Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae. Infect Immun (2003) 1.15

Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae. Microb Pathog (2007) 1.13

Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. Mol Pharmacol (2005) 1.13

ChIP-chip for genome-wide analysis of protein binding in mammalian cells. Curr Protoc Mol Biol (2007) 1.11

CBX3 regulates efficient RNA processing genome-wide. Genome Res (2012) 1.10

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet (2012) 1.07

Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1. Proc Natl Acad Sci U S A (2014) 1.04

Enhancers: multi-dimensional signal integrators. Transcription (2012) 1.02

Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing. Genome Biol (2010) 1.01

Developmental biology. Enhancing pluripotency and lineage specification. Science (2013) 0.99

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat Commun (2013) 0.99

Genome-wide location analysis: insights on transcriptional regulation. Hum Mol Genet (2006) 0.96

Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res (2006) 0.94

Comparative annotation of functional regions in the human genome using epigenomic data. Nucleic Acids Res (2013) 0.94

Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood (2012) 0.92

Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual. Nucleic Acids Res (2011) 0.88

p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell (2010) 0.88

[Continuous veno-venous hemofiltration in treatment of acute severe hyponatremia: a report of 6 cases]. Zhonghua Nei Ke Za Zhi (2003) 0.84

Programmed Death-Ligand 1 Expression Is Common in Gastric Cancer Associated With Epstein-Barr Virus or Microsatellite Instability. Am J Surg Pathol (2016) 0.83

Mapping higher order structure of chromatin domains. Nat Genet (2011) 0.83

Histone acetyltransferase cofactor Trrap maintains self-renewal and restricts differentiation of embryonic stem cells. Stem Cells (2013) 0.83

Clinical observation on removal of small foreign bodies touching the optic nerve in the deep orbital region: a case series. Orbit (2014) 0.82

Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells. Nucleic Acids Res (2012) 0.80

Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells. Genome Res (2013) 0.79

STAR: an integrated solution to management and visualization of sequencing data. Bioinformatics (2013) 0.78

Corrigendum: Human body epigenome maps reveal noncanonical DNA methylation variation. Nature (2015) 0.77

Effects of aminoguanidine on retinal apoptosis in mice with oxygen-induced retinopathy. Int J Ophthalmol (2013) 0.76

Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease. Proc Natl Acad Sci U S A (2014) 0.76

SERPINB13 is a novel RUNX1 target gene. Biochem Biophys Res Commun (2011) 0.76

Effects of minocycline on expression of bcl-2, bax in early retinal neuropathy of diabetes in rats. Int J Ophthalmol (2011) 0.75

Comparative study of modified and conventional secondary hydroxyapatite orbital implantations. Int J Ophthalmol (2013) 0.75

[Near-infrared spectroscopy analysis of adenosine and water in fermentation cordyceps powder and wavelength assignment]. Guang Pu Xue Yu Guang Pu Fen Xi (2012) 0.75

An all-round view of eukaryotic transcription. Genome Biol (2006) 0.75

Preliminary in vivo study of an intra-aortic impeller pump driven by an extracorporeal whirling magnet. Artif Organs (2002) 0.75