Published in Genes Dev on February 15, 2009
The extracellular matrix: not just pretty fibrils. Science (2009) 8.52
Integrins. Cell Tissue Res (2009) 4.11
Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science (2010) 3.53
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep (2010) 2.32
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
SHARPIN is an endogenous inhibitor of β1-integrin activation. Nat Cell Biol (2011) 2.01
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
Combinatorial and distinct roles of α₅ and α₄ integrins in stress erythropoiesis in mice. Blood (2010) 1.72
Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. Blood (2011) 1.68
Serum response factor is an essential transcription factor in megakaryocytic maturation. Blood (2010) 1.65
A long non-coding RNA signature to improve prognosis prediction of colorectal cancer. Oncotarget (2014) 1.64
The tail of integrin activation. Trends Biochem Sci (2011) 1.62
Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res (2012) 1.56
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Filopodia and adhesion in cancer cell motility. Cell Adh Migr (2011) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
The cell biology of touch. J Cell Biol (2010) 1.45
Extracellular matrix: a dynamic microenvironment for stem cell niche. Biochim Biophys Acta (2014) 1.45
Integrin alpha5beta1 function is regulated by XGIPC/kermit2 mediated endocytosis during Xenopus laevis gastrulation. PLoS One (2010) 1.45
Integrin targeted therapeutics. Theranostics (2011) 1.36
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Adhesion in the stem cell niche: biological roles and regulation. Development (2013) 1.30
The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil Cytoskeleton (2009) 1.29
Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. J Cell Biol (2011) 1.27
Basement membrane components are key players in specialized extracellular matrices. Cell Mol Life Sci (2010) 1.22
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opin Cell Biol (2012) 1.21
TAN lines: a novel nuclear envelope structure involved in nuclear positioning. Nucleus (2011) 1.20
Integrin trafficking at a glance. J Cell Sci (2012) 1.19
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol (2011) 1.16
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J (2009) 1.15
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13
Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis. EMBO J (2011) 1.12
Cell-matrix interactions in dermal repair and scarring. Fibrogenesis Tissue Repair (2010) 1.11
Dystroglycan versatility in cell adhesion: a tale of multiple motifs. Cell Commun Signal (2010) 1.11
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J (2010) 1.10
Integrin cytoplasmic tail interactions. Biochemistry (2014) 1.10
Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev (2012) 1.09
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci (2013) 1.08
Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci (2010) 1.06
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model. J Neurosci (2014) 1.06
Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res (2009) 1.05
β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Res (2011) 1.05
beta2-integrins in demyelinating disease: not adhering to the paradigm. J Leukoc Biol (2009) 1.03
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake. Proc Natl Acad Sci U S A (2010) 1.03
Fibronectin at select sites binds multiple growth factors and enhances their activity: expansion of the collaborative ECM-GF paradigm. J Invest Dermatol (2013) 1.01
Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. J Biol Chem (2011) 1.01
A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Dev Biol (2013) 0.99
Vinculin and talin: focus on the myocardium. J Investig Med (2009) 0.99
Cellular nanotechnology: making biological interfaces smarter. Chem Soc Rev (2013) 0.99
Biochemical and mechanical environment cooperatively regulate skeletal muscle regeneration. FASEB J (2012) 0.98
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms. Biol Reprod (2013) 0.97
Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells. J Clin Invest (2013) 0.96
Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion. J Biol Chem (2013) 0.96
The EMILIN/Multimerin family. Front Immunol (2012) 0.96
Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol (2010) 0.94
Copy number analysis of the murine platelet proteome spanning the complete abundance range. Mol Cell Proteomics (2014) 0.94
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development (2010) 0.93
Beta3-integrin mediates satellite cell differentiation in regenerating mouse muscle. FASEB J (2011) 0.93
Mechanism of regulation of stem cell differentiation by matrix stiffness. Stem Cell Res Ther (2015) 0.93
α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3. J Cell Biol (2015) 0.92
Stabilising influence: integrins in regulation of synaptic plasticity. Neurosci Res (2011) 0.91
Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway. Exp Cell Res (2010) 0.91
Lessons from the embryonic neural stem cell niche for neural lineage differentiation of pluripotent stem cells. Stem Cell Rev (2012) 0.90
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nat Commun (2015) 0.90
Functional differences between kindlin-1 and kindlin-2 in keratinocytes. J Cell Sci (2012) 0.90
Epigenetic regulation of galectin-3 expression by β1 integrins promotes cell adhesion and migration. J Biol Chem (2012) 0.89
Paired immunoglobulin-like receptor B regulates platelet activation. Blood (2014) 0.89
Perspectives on: information and coding in mammalian sensory physiology: probing mammalian touch transduction. J Gen Physiol (2011) 0.89
Mass spectrometry-based proteomic analysis of the matrix microenvironment in pluripotent stem cell culture. Mol Cell Proteomics (2012) 0.88
Integrin βν-mediated phagocytosis of apoptotic cells in Drosophila embryos. J Biol Chem (2011) 0.88
Integrins and chondrocyte-matrix interactions in articular cartilage. Matrix Biol (2014) 0.87
Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1-IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation. J Biol Chem (2012) 0.87
Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway. J Biol Chem (2013) 0.87
Erythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses. Haematologica (2013) 0.87
Hepatic stellate cells: central modulators of hepatic carcinogenesis. BMC Gastroenterol (2015) 0.86
MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. Development (2014) 0.86
NELL-1 in the treatment of osteoporotic bone loss. Nat Commun (2015) 0.86
ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis. Cell Rep (2015) 0.85
CD36 recruits α₅β₁ integrin to promote cytoadherence of P. falciparum-infected erythrocytes. PLoS Pathog (2013) 0.85
Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2. J Cardiovasc Transl Res (2015) 0.84
α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One (2011) 0.84
Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One (2012) 0.84
Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylation. J Neurosci (2013) 0.83
A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells. J Biol Chem (2010) 0.83
Nox family NADPH oxidases in mechano-transduction: mechanisms and consequences. Antioxid Redox Signal (2013) 0.83
Importance of the stem cell microenvironment for ophthalmological cell-based therapy. World J Stem Cells (2015) 0.82
Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. PLoS One (2012) 0.82
ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells. Sci Rep (2016) 0.82
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol Cell Biol (2012) 0.82
Vitamin a deficiency and alterations in the extracellular matrix. Nutrients (2014) 0.82
Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol (2015) 0.82
AT14A mediates the cell wall-plasma membrane-cytoskeleton continuum in Arabidopsis thaliana cells. J Exp Bot (2012) 0.82
The complexity of integrins in cancer and new scopes for therapeutic targeting. Br J Cancer (2016) 0.81
β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis. J Invest Dermatol (2013) 0.81
β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. PLoS One (2013) 0.81
Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption. J Cell Biochem (2010) 0.81
Another look at "Stem cell fate dictated solely by altered nanotube dimension". Proc Natl Acad Sci U S A (2009) 0.81
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
The Kindlins: subcellular localization and expression during murine development. Exp Cell Res (2006) 2.36
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci (2009) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol (2005) 2.10
The role of laminin in embryonic cell polarization and tissue organization. Dev Cell (2003) 2.05
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell (2008) 1.70
Laminin: the crux of basement membrane assembly. J Cell Biol (2004) 1.69
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res (2008) 1.68
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest (2008) 1.67
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep (2003) 1.63
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med (2009) 1.59
The Kindlin protein family: new members to the club of focal adhesion proteins. Trends Cell Biol (2009) 1.57
Cylindroma as tumor of hair follicle origin. J Invest Dermatol (2006) 1.56
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol (2012) 1.48
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol (2002) 1.48
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability. Circ Res (2008) 1.43
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity (2002) 1.38
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J Cell Sci (2008) 1.38
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol (2006) 1.37
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. J Cell Sci (2005) 1.34
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol (2002) 1.31
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J (2003) 1.28
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A (2009) 1.27
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27
Integrin-linked kinase: integrin's mysterious partner. Curr Opin Cell Biol (2004) 1.27
Integrins are required for the differentiation of visceral endoderm. J Cell Sci (2009) 1.26
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci (2006) 1.24
Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis. Sci Signal (2009) 1.24
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol (2008) 1.24
The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol (2013) 1.22
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci (2005) 1.22
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J (2009) 1.21
Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. Methods Enzymol (2007) 1.21
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration. J Neurosci (2012) 1.21
The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. Gene Expr Patterns (2003) 1.21
Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol (2007) 1.20
Mechanoinduction of lymph vessel expansion. EMBO J (2011) 1.19
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation. J Cell Sci (2009) 1.19
Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J (2009) 1.19
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
Adult murine hematopoiesis can proceed without beta1 and beta7 integrins. Blood (2006) 1.16
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev Biol (2007) 1.16
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res (2003) 1.16
Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med (2012) 1.16
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J (2009) 1.15