The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle.

Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts. J Cell Biol (1992) 3.99

The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc Natl Acad Sci U S A (1992) 1.79

Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc Natl Acad Sci U S A (1992) 1.45

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc Natl Acad Sci U S A (1994) 1.45

The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin. Proc Natl Acad Sci U S A (1998) 1.05

Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation. BMC Syst Biol (2009) 0.99

Toward system-level understanding of baculovirus-host cell interactions: from molecular fundamental studies to large-scale proteomics approaches. Front Microbiol (2012) 0.90

Alterations in the distribution of histone H3 phosphorylation in mitotic plant chromosomes in response to cold treatment and the protein phosphatase inhibitor cantharidin. Chromosome Res (2002) 0.81

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17

p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (1993) 13.68

Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell (1999) 8.55

Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (1994) 8.22

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25

Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell (1988) 6.88

Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J (1994) 6.83

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell (1988) 6.45

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (1993) 5.70

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51

Human D-type cyclin. Cell (1991) 5.47

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (1995) 5.46

Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell (1989) 5.35

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev (1993) 5.32

Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet (1982) 5.17

Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00

Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell (1989) 4.68

The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. EMBO J (1987) 4.45

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A (1996) 4.33

Cdc25 cell-cycle phosphatase as a target of c-myc. Nature (1996) 4.23

cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell (1988) 4.12

p21-containing cyclin kinases exist in both active and inactive states. Genes Dev (1994) 4.08

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell (1995) 4.08

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J (1987) 3.91

Functionally homologous cell cycle control genes in budding and fission yeast. Nature (1982) 3.78

Myc activates telomerase. Genes Dev (1998) 3.74

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70

Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61

Construction of an improved host strain for two hybrid screening. Nucleic Acids Res (1994) 3.43

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell (1991) 3.37

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell (1991) 3.34

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J (1988) 3.27

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature (1994) 3.21

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell (1987) 3.12

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell (1989) 3.08

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature (1989) 3.07

CDC25 phosphatases as potential human oncogenes. Science (1995) 2.84

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A (1990) 2.77

Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J (1989) 2.75

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature (1989) 2.67

Repression of cyclin D1: a novel function of MYC. Mol Cell Biol (1994) 2.67

Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1986) 2.66

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J (1994) 2.64

Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Plasmid (1986) 2.58

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell (1993) 2.57

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet (1986) 2.46

Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature (1990) 2.46

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc Natl Acad Sci U S A (1992) 2.43

Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science (1995) 2.42

Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J (1986) 2.31

Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst (1995) 2.25

Isolation of chromosomal origins of replication in yeast. Nature (1980) 2.20

Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell (1993) 2.19

Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control. Cell (1989) 2.16

Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe. Mol Cell Biol (1987) 2.13

Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J (1987) 2.10

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell (1990) 2.08

Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene (1995) 2.05

A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe. Nature (1988) 1.87

Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes Dev (1990) 1.86

Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit. Proc Natl Acad Sci U S A (1989) 1.80

Homology between the ran1+ gene of fission yeast and protein kinases. EMBO J (1986) 1.76

Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J (1991) 1.72

Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics (1992) 1.70

Mutations associated with familial melanoma impair p16INK4 function. Nat Genet (1995) 1.69

Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast. Dev Cell (2001) 1.60

MaRX: an approach to genetics in mammalian cells. Science (1999) 1.58

Two new multi-purpose multicopy Schizosaccharomyces pombe shuttle vectors, pSP1 and pSP2. Curr Genet (1993) 1.58

Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis. J Cell Sci (1993) 1.58

A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Mol Biol Cell (1996) 1.55

Physical interaction of mammalian CDC37 with CDK4. J Biol Chem (1996) 1.53

Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle. Mol Cell Biol (1994) 1.50

p53-independent role of MDM2 in TGF-beta1 resistance. Science (1998) 1.48

Population explosion in the cyclin family. Curr Biol (1991) 1.46

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc Natl Acad Sci U S A (1994) 1.45

Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B. Cell (1992) 1.44

14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci U S A (1995) 1.44

Prospective evaluation of three smoking interventions in 205 recovering alcoholics: one-year results of Project SCRAP-Tobacco. J Consult Clin Psychol (1997) 1.42

Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun (1990) 1.41

Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol (1996) 1.41

Molecular rearrangement of mating-type genes in fission yeast. Nature (1982) 1.41

Human p53 inhibits growth in Schizosaccharomyces pombe. Mol Cell Biol (1992) 1.38

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25. EMBO J (1996) 1.37

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev (1995) 1.33

cdc2 and the regulation of mitosis: six interacting mcs genes. Genetics (1989) 1.32

An alternative eukaryotic DNA excision repair pathway. Mol Cell Biol (1995) 1.31

Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J (1993) 1.31

A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle. EMBO J (1991) 1.30

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene (1999) 1.29