Published in Curr HIV Res on January 01, 2016
Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links. Front Mol Biosci (2017) 0.75
Macrophages and Phospholipases at the Intersection between Inflammation and the Pathogenesis of HIV-1 Infection. Int J Mol Sci (2017) 0.75
JC Polyomavirus Attachment and Entry: Potential Sites for PML Therapeutics. Curr Clin Microbiol Rep (2017) 0.75
Updated research nosology for HIV-associated neurocognitive disorders. Neurology (2007) 16.18
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology (2010) 12.32
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 11.07
The neuropathogenesis of AIDS. Nat Rev Immunol (2005) 6.54
Nanotubular highways for intercellular organelle transport. Science (2004) 6.04
Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem (1987) 4.99
Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev (2003) 4.87
Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol (1999) 4.87
Exosome function: from tumor immunology to pathogen biology. Traffic (2008) 4.50
Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol (2007) 4.37
Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol (2008) 4.34
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol (2006) 4.33
Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta (2012) 4.33
Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem (2002) 3.99
Exosomes: from biogenesis and secretion to biological function. Immunol Lett (2006) 3.82
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest (1998) 3.66
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J Virol (2007) 3.58
Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol (2009) 3.55
The Trojan exosome hypothesis. Proc Natl Acad Sci U S A (2003) 3.45
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17
Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J Neurosci (2003) 3.14
Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nat Med (2000) 3.10
Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap. Ann Neurol (2010) 2.96
Functional connectivity between immune cells mediated by tunneling nanotubules. Immunity (2005) 2.83
Neuronal loss in the frontal cortex in HIV infection. Lancet (1991) 2.71
Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. Annu Rev Immunol (1990) 2.69
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol (2006) 2.65
HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ (2005) 2.54
HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic (2010) 2.47
Cutting edge: Membrane nanotubes connect immune cells. J Immunol (2004) 2.47
Proteomic analysis of exosomes isolated from human malignant pleural effusions. Am J Respir Cell Mol Biol (2004) 2.44
Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A (2010) 2.34
Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PLoS Biol (2007) 2.30
New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci (2003) 2.25
HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat Immunol (2009) 2.23
MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem (2003) 2.21
Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Ann Neurol (2009) 2.14
Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. AIDS (2006) 2.13
Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS (2003) 2.12
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci (2007) 2.06
Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis. Brain Pathol (2002) 2.03
Tunneling nanotubes: a new route for the exchange of components between animal cells. FEBS Lett (2007) 2.01
Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis. Trends Cell Biol (2008) 1.99
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat Cell Biol (2009) 1.87
HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities. J Neuroimmune Pharmacol (2010) 1.87
HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology (1994) 1.86
Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV. J Virol (1987) 1.84
Endosomes, exosomes and Trojan viruses. Trends Microbiol (2004) 1.84
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS (1999) 1.84
Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy. Arch Neurol (2004) 1.79
Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol (1996) 1.78
Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking. Cell Immunol (2008) 1.77
Gap junctions and connexin expression in the normal and pathological central nervous system. Biol Cell (2002) 1.77
Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms. AIDS (2004) 1.75
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci U S A (2006) 1.74
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes. Proc Natl Acad Sci U S A (2007) 1.71
Identification and proteomic profiling of exosomes in human cerebrospinal fluid. J Transl Med (2012) 1.70
Identification of connexin43 as a functional target for Wnt signalling. J Cell Sci (1998) 1.64
Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein. PLoS Pathog (2007) 1.61
Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS (1995) 1.59
Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread. Proc Natl Acad Sci U S A (2005) 1.59
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. J Neurochem (2011) 1.52
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes. J Leukoc Biol (2013) 1.51
Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. Curr HIV Res (2003) 1.47
TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol (2003) 1.46
Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol (1990) 1.45
Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism. J Neurosci (2011) 1.43
Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes. J Cell Sci (2005) 1.43
Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J Immunol (2012) 1.42
Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging. Neurology (1993) 1.39
Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology (2003) 1.39
Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Res (2014) 1.38
The art of cellular communication: tunneling nanotubes bridge the divide. Histochem Cell Biol (2008) 1.38
Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma. Clin Infect Dis (2005) 1.35
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34
Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc Natl Acad Sci U S A (2001) 1.34
Regulation of connexin expression. Biochim Biophys Acta (2005) 1.34
Gap junctions mediate human immunodeficiency virus-bystander killing in astrocytes. J Neurosci (2007) 1.33
Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. J Neurochem (1999) 1.32
Astrocytic gap junctional communication decreases neuronal vulnerability to oxidative stress-induced disruption of Ca2+ homeostasis and cell death. J Neurochem (1998) 1.32
Gap junction hemichannels in astrocytes of the CNS. Acta Physiol Scand (2003) 1.31
Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA. J Biol Chem (2013) 1.31
Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes. J Virol (2001) 1.28
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9. BMC Cancer (2006) 1.26
HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals. AIDS Res Hum Retroviruses (2010) 1.26
Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J Virol (2004) 1.24
Tunnelling nanotubes: a highway for prion spreading? Prion (2009) 1.22
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection. J Exp Med (2011) 1.22
HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions. Ethn Dis (2008) 1.22
Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis. J Leukoc Biol (2012) 1.22
Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology (2008) 1.19
IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. J Immunol (2011) 1.18
Influence of highly active antiretroviral therapy on persistence of HIV in the central nervous system. Curr Opin Neurol (2006) 1.18
Glial connexins and gap junctions in CNS inflammation and disease. J Neurochem (2008) 1.17
HIV mediates a productive infection of the brain. AIDS (1999) 1.15
Modulation of B-cell exosome proteins by gamma herpesvirus infection. Proc Natl Acad Sci U S A (2013) 1.14