Published in Traffic on March 06, 2008
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol (2011) 9.68
Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol (2009) 5.01
Microvesicles: mediators of extracellular communication during cancer progression. J Cell Sci (2010) 3.35
Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One (2010) 3.14
Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis (2009) 3.11
Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer (2008) 3.04
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol (2010) 2.85
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol (2010) 2.52
HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic (2010) 2.47
Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Rev (2013) 2.46
Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res (2008) 2.41
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. PLoS Pathog (2009) 2.37
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors. Nat Rev Microbiol (2010) 2.37
Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A (2010) 2.34
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis (2011) 2.32
Characterization of human plasma-derived exosomal RNAs by deep sequencing. BMC Genomics (2013) 2.27
Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One (2012) 2.23
Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev (2012) 2.22
Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS One (2010) 2.11
Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles (2014) 2.11
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J (2009) 2.07
Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J Neural Transm (Vienna) (2009) 1.97
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics (2010) 1.97
Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. J Mol Cell Cardiol (2014) 1.94
Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin Immunopathol (2011) 1.93
Amphiregulin exosomes increase cancer cell invasion. Curr Biol (2011) 1.93
Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer (2012) 1.92
Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. Am J Physiol Gastrointest Liver Physiol (2010) 1.85
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J Lipid Res (2010) 1.82
Nanotubes, exosomes, and nucleic acid-binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease. J Cell Biol (2008) 1.77
Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer (2011) 1.76
Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A (2012) 1.72
Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones (2010) 1.69
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev (2012) 1.68
Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. J Virol (2010) 1.67
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front Physiol (2012) 1.65
Paracrine induction of endothelium by tumor exosomes. Lab Invest (2009) 1.63
Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet (2012) 1.60
Protein targeting to exosomes/microvesicles by plasma membrane anchors. J Biol Chem (2011) 1.56
Tetraspanins in extracellular vesicle formation and function. Front Immunol (2014) 1.56
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics (2012) 1.55
Lymphocyte cytosolic protein 1 is a chronic lymphocytic leukemia membrane-associated antigen critical to niche homing. Blood (2013) 1.50
Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J Immunol (2012) 1.42
Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. J Biol Chem (2012) 1.40
Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications. Front Immunol (2015) 1.37
Vesicular transport across the fungal cell wall. Trends Microbiol (2009) 1.36
Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome. Int J Proteomics (2012) 1.36
Nucleic acid delivery: the missing pieces of the puzzle? Acc Chem Res (2012) 1.36
Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis. Int J Cancer (2011) 1.34
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J Extracell Vesicles (2015) 1.30
Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages. Proteomics (2010) 1.28
Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Mol Cell Proteomics (2012) 1.26
IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol (2013) 1.24
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment. Cold Spring Harb Perspect Biol (2010) 1.20
Exosomes and other extracellular vesicles in host-pathogen interactions. EMBO Rep (2014) 1.19
The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol (2013) 1.18
Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells. Virol J (2010) 1.18
Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery. J Biol Chem (2014) 1.17
Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-β/Smad pathway. PLoS One (2012) 1.17
A model of cancer stem cells derived from mouse induced pluripotent stem cells. PLoS One (2012) 1.17
Microvesicles derived from human Wharton's Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1. Stem Cell Res Ther (2014) 1.14
Trichomonas vaginalis exosomes deliver cargo to host cells and mediate host∶parasite interactions. PLoS Pathog (2013) 1.11
Exosomes: novel biomarkers for clinical diagnosis. ScientificWorldJournal (2015) 1.11
Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections. PLoS One (2011) 1.10
The complete exosome workflow solution: from isolation to characterization of RNA cargo. Biomed Res Int (2013) 1.10
Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo. J Immunol (2012) 1.09
Human urinary exosomes as innate immune effectors. J Am Soc Nephrol (2014) 1.07
Comparative marker analysis of extracellular vesicles in different human cancer types. J Extracell Vesicles (2013) 1.06
Biogenesis of the posterior pole is mediated by the exosome/microvesicle protein-sorting pathway. J Biol Chem (2011) 1.05
Potential of soluble CD26 as a serum marker for colorectal cancer detection. World J Clin Oncol (2011) 1.04
Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology. BMC Clin Pathol (2015) 1.02
XenomiRs and miRNA homeostasis in health and disease: evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles. RNA Biol (2012) 1.02
Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab Syndr Obes (2012) 1.01
COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Am J Pathol (2009) 1.01
Exploration of microRNAs in porcine milk exosomes. BMC Genomics (2014) 1.01
Physiology of cholangiocytes. Compr Physiol (2013) 1.00
Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS. PLoS One (2014) 1.00
Identification of an inhibitory budding signal that blocks the release of HIV particles and exosome/microvesicle proteins. Mol Biol Cell (2011) 1.00
Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals. J Extracell Vesicles (2015) 1.00
Extracellular vesicles in parasitic diseases. J Extracell Vesicles (2014) 0.99
Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging. Anal Chem (2014) 0.99
Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation. Infect Immun (2010) 0.99
CD9-positive microvesicles mediate the transfer of molecules to Bovine Spermatozoa during epididymal maturation. PLoS One (2013) 0.98
Mesenchymal stem cells and acute lung injury. Crit Care Clin (2011) 0.98
Exosomes released from M. tuberculosis infected cells can suppress IFN-γ mediated activation of naïve macrophages. PLoS One (2011) 0.98
Exosomal lipids impact notch signaling and induce death of human pancreatic tumoral SOJ-6 cells. PLoS One (2012) 0.97
Methods for the extraction and RNA profiling of exosomes. World J Methodol (2013) 0.97
Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. PLoS Negl Trop Dis (2013) 0.96
Quantitative nanostructural and single-molecule force spectroscopy biomolecular analysis of human-saliva-derived exosomes. Langmuir (2011) 0.96
Vesicular transport systems in fungi. Future Microbiol (2011) 0.95
Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses. Viruses (2015) 0.95
Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease. Neurobiol Aging (2009) 0.92
Therapeutic implications of Epstein-Barr virus infection for the treatment of nasopharyngeal carcinoma. Ther Clin Risk Manag (2014) 0.92
Exosomes carrying mycobacterial antigens can protect mice against Mycobacterium tuberculosis infection. Eur J Immunol (2013) 0.90
Exosome-driven antigen transfer for MHC class II presentation facilitated by the receptor binding activity of influenza hemagglutinin. J Immunol (2010) 0.90
Quantification and size-profiling of extracellular vesicles using tunable resistive pulse sensing. J Vis Exp (2014) 0.90
Human semen contains exosomes with potent anti-HIV-1 activity. Retrovirology (2014) 0.89
Extracellular vesicles from infected cells: potential for direct pathogenesis. Front Microbiol (2015) 0.89
Exosomes: an overview of biogenesis, composition and role in ovarian cancer. J Ovarian Res (2014) 0.88
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol (2007) 37.10
Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50
B lymphocytes secrete antigen-presenting vesicles. J Exp Med (1996) 11.53
Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A (2004) 8.74
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med (1998) 6.36
Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol (2001) 6.32
Exosomal-like vesicles are present in human blood plasma. Int Immunol (2005) 6.04
Exosomes: a common pathway for a specialized function. J Biochem (2006) 5.79
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med (2001) 5.71
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci (2000) 5.57
Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem (1987) 4.99
Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol (1999) 4.87
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J Biol Chem (2003) 4.14
Biogenesis and function of multivesicular bodies. Annu Rev Cell Dev Biol (2007) 4.08
Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol (2003) 3.68
Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol (1985) 3.63
The Trojan exosome hypothesis. Proc Natl Acad Sci U S A (2003) 3.45
Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ (2007) 3.22
The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res (2006) 3.22
Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med (2002) 3.02
CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int (2007) 3.01
Evidence that HIV budding in primary macrophages occurs through the exosome release pathway. J Biol Chem (2003) 2.97
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood (2007) 2.92
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Dev Cell (2004) 2.86
Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol Biol Cell (1997) 2.78
Lipid raft-associated protein sorting in exosomes. Blood (2003) 2.76
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res (2005) 2.72
Discovery of urinary biomarkers. Mol Cell Proteomics (2006) 2.70
Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? Virology (2007) 2.68
In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol (2007) 2.68
Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity (2006) 2.66
Trafficking and release of mycobacterial lipids from infected macrophages. Traffic (2000) 2.65
Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci (2005) 2.58
Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics (2004) 2.43
Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PLoS Biol (2007) 2.30
A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis. Dev Cell (2006) 2.29
Proteomic analysis of exosomes secreted by human mesothelioma cells. Am J Pathol (2004) 2.13
Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. Biochem J (2004) 2.00
Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J (2003) 1.97
Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J Biol Chem (2007) 1.96
"Tolerosomes" are produced by intestinal epithelial cells. Eur J Immunol (2001) 1.93
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J (2006) 1.92
Endosomes, exosomes and Trojan viruses. Trends Microbiol (2004) 1.84
Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation. J Cell Sci (1997) 1.80
Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies. Biochimie (2006) 1.78
Prospects for urinary proteomics: exosomes as a source of urinary biomarkers. Nephrology (Carlton) (2005) 1.77
Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol (2005) 1.74
Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci (2003) 1.73
TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J Biol Chem (2004) 1.72
Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol Biol Cell (2003) 1.72
Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles. J Immunol (1999) 1.65
T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology (2007) 1.60
Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol (2006) 1.57
Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol Dis (2005) 1.54
Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event. Eur J Cell Biol (2001) 1.50
T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J (2007) 1.47
HIV-1 buds and accumulates in "nonacidic" endosomes of macrophages. Cell Host Microbe (2007) 1.47
Identification and macrophage-activating activity of glycolipids released from intracellular Mycobacterium bovis BCG. Mol Microbiol (2003) 1.45
Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice. Gut (2003) 1.44
Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther (2005) 1.38
Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation (2003) 1.37
A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J Immunol (2006) 1.36
Dendritic cell derived-exosomes: biology and clinical implementations. J Leukoc Biol (2006) 1.34
Tumor-derived exosomes: a new source of tumor rejection antigens. Vaccine (2002) 1.33
Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes. Traffic (2004) 1.31
Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells. Blood Cells Mol Dis (2005) 1.31
Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol (2007) 1.30
Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction. Crit Care (2007) 1.26
Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect Immun (2004) 1.22
Cell biology: The ins and outs of exosomes. Science (2005) 1.20
Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol (2006) 1.19
Loss of the transferrin receptor during the maturation of sheep reticulocytes in vitro. An immunological approach. Biochem J (1983) 1.16
Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity. Immunology (2006) 1.16
Intracellular trafficking of raft/caveolae domains: insights from integrin signaling. Semin Cell Dev Biol (2007) 1.15
Exosome Display technology: applications to the development of new diagnostics and therapeutics. Blood Cells Mol Dis (2005) 1.14
Prions and exosomes: from PrPc trafficking to PrPsc propagation. Blood Cells Mol Dis (2005) 1.12
MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J Immunol (2007) 1.10
Asymmetric distribution of phospholipids in the membrane of vesicles released during in vitro maturation of guinea pig reticulocytes: evidence precluding a role for "aminophospholipid translocase". J Cell Physiol (1989) 1.09
Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen. J Immunol (2006) 1.08
Platelet-derived exosomes from septic shock patients induce myocardial dysfunction. Crit Care (2007) 1.07
The fate of the transferrin receptor during maturation of sheep reticulocytes in vitro. Can J Biochem Cell Biol (1984) 1.06
Annexins and endocytosis. Traffic (2007) 1.05
A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice. Microbes Infect (2007) 1.04
Exosomes for cancer immunotherapy. Ann Oncol (2004) 1.03
Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes. Cell Mol Immunol (2006) 1.02
Dendritic cell-derived exosomes express a Streptococcus pneumoniae capsular polysaccharide type 14 cross-reactive antigen that induces protective immunoglobulin responses against pneumococcal infection in mice. Infect Immun (2006) 1.01
Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis. Infect Immun (2005) 1.01
Saposin C-LBPA interaction in late-endosomes/lysosomes. Exp Cell Res (2005) 1.01
Review: cancer immunotherapy by exosome-based vaccines. Cancer Biother Radiopharm (2007) 1.00
Exosomes as novel therapeutic nanodevices. Curr Opin Mol Ther (2006) 0.98
Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies. Virology (2007) 0.95
Biogenesis of the apical endosome-lysosome complex during differentiation of absorptive epithelial cells in rat ileum. J Cell Sci (1991) 0.94
Bacterial meningitis: the impact of vaccination. CNS Drugs (2007) 0.93
Pneumococcus: the sugar-coated bacteria. Int Microbiol (2006) 0.85