Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 27206316)

Published in Cell Death Differ on May 20, 2016

Authors

Z Dong1, M Huang2, Z Liu2, P Xie1, Y Dong2, X Wu1, Z Qu1, B Shen1, X Huang1, T Zhang2, J Li3, J Liu1, T Yanase4, C Zhou5, Ying Xu6

Author Affiliations

1: MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
2: Cambridge-Suda Genomic Research Center, Soochow University, Suzhou, China.
3: State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
4: Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University, Fukuoka, Japan.
5: Department of Biochemistry and Molecular Medicine and Comprehensive Cancer Center, Institute for Pediatric Regenerative Medicine, University of California Davis, School of Medicine, Sacramento, CA, USA.
6: Center for System Biology, Soochow University, Suzhou, China.

Articles citing this

Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS One (2017) 0.75

Articles cited by this

mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92

Genome-scale CRISPR-Cas9 knockout screening in human cells. Science (2013) 12.36

The expanding role of mitochondria in apoptosis. Genes Dev (2001) 9.91

p53 regulates mitochondrial respiration. Science (2006) 9.06

Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev (2008) 6.57

Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature (2004) 6.47

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science (2010) 6.38

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (1994) 4.77

Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol (1997) 4.46

PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer (2011) 4.37

Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet (2004) 4.11

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem (2000) 4.11

Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science (2008) 3.80

Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science (2002) 3.40

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods (2014) 3.34

The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98

MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science (2009) 2.86

Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Nat Genet (2002) 2.75

Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39

Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice. Biol Reprod (2004) 2.29

Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor. Endocrinology (2001) 2.05

PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Cell Metab (2014) 2.01

HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev (1997) 1.83

WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80

Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation. Development (2008) 1.68

Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence. Reproduction (2004) 1.56

DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion (2009) 1.50

Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. EMBO J (2001) 1.45

Mechanisms maintaining the dormancy and survival of mammalian primordial follicles. Trends Endocrinol Metab (2009) 1.37

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. Mol Hum Reprod (2009) 1.36

Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia. Endocrinology (1991) 1.23

The HBP1 transcriptional repressor participates in RAS-induced premature senescence. Mol Cell Biol (2006) 1.16

Human HMG box transcription factor HBP1: a role in hCD2 LCR function. EMBO J (1999) 1.12

Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. Mol Cell Biol (2011) 1.10

Cryopreservation and orthotopic transplantation of mouse ovaries: new approach in gamete banking. Biol Reprod (1998) 1.10

Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. Cancer Res (2007) 1.08

p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells. J Biol Chem (2005) 1.06

The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression. Gene (2004) 1.01

Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proc Natl Acad Sci U S A (2013) 0.97

The transcriptional targets of mutant FOXL2 in granulosa cell tumours. PLoS One (2012) 0.97

Delaying the mitochondrial decay of aging with acetylcarnitine. Ann N Y Acad Sci (2004) 0.95

Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice. Nat Commun (2013) 0.87

HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Dev Dyn (2004) 0.87

Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. Endocrinology (2010) 0.86

XIAP: a potential determinant of ovarian follicular fate. Reproduction (2012) 0.79