Epigenetic regulation of LSD1 during mammary carcinogenesis.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27308339)

Published in Mol Cell Oncol on December 23, 2014

Authors

Yadi Wu1, Binhua P Zhou2

Author Affiliations

1: Department of Pharmacology and Nutrition Science; College of Medicine; University of Kentucky; Lexington, KY USA; Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA.
2: Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA; Department of Molecular and Cellular Biochemistry; College of Medicine; University of Kentucky; Lexington, KY USA.

Articles cited by this

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38

The epigenomics of cancer. Cell (2007) 30.91

Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30

Cancer metastasis: building a framework. Cell (2006) 19.67

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69

The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70

The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53

Cancer epigenetics: from mechanism to therapy. Cell (2012) 7.74

Breast cancer statistics, 2011. CA Cancer J Clin (2011) 6.12

Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell (2005) 5.74

Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet (2012) 5.42

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell (2007) 4.45

Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67

The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64

Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol (2012) 3.40

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med (2012) 3.03

Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell (2010) 2.86

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis (2009) 2.54

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol (2007) 2.50

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer (2011) 2.42

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell (2012) 2.26

Human histone demethylase LSD1 reads the histone code. J Biol Chem (2005) 2.14

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A (2007) 2.11

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature (2010) 2.01

Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol (2006) 1.94

Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell (2010) 1.92

Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res (2010) 1.88

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett (2005) 1.82

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene (2010) 1.80

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells. Nat Cell Biol (2011) 1.76

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun (2011) 1.67

Lysine methylation regulates E2F1-induced cell death. Mol Cell (2010) 1.63

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59

Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc Natl Acad Sci U S A (2012) 1.59

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A (2009) 1.58

Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. PLoS One (2012) 1.56

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55

Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol (2010) 1.47

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell (2012) 1.44

Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells. Breast Cancer Res Treat (2011) 1.18

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer (2012) 1.18

Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med (2011) 1.11

LSD1 demethylates histone and non-histone proteins. Epigenetics (2009) 1.11

Carcinogen-induced histone alteration in normal human mammary epithelial cells. Carcinogenesis (2007) 1.06

Selective estrogen receptor modulators: clinical spectrum. Endocr Rev (1999) 1.03

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia (2014) 1.03

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids (2011) 1.03

Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells. Cell Rep (2013) 0.99

The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells. Cell Rep (2013) 0.97

Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis. Oncogene (2012) 0.97

Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis (2013) 0.96

The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol (2013) 0.96

LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process. Cancer Lett (2014) 0.94

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nat Commun (2014) 0.94

Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol (2012) 0.94

Phosphorylation of LSD1 by PKCα is crucial for circadian rhythmicity and phase resetting. Mol Cell (2014) 0.93

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A. Int J Cancer (2013) 0.92

Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast. BMC Clin Pathol (2012) 0.92

A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol (2014) 0.92

Field cancerization in mammary carcinogenesis - Implications for prevention and treatment of breast cancer. Exp Mol Pathol (2012) 0.92

LSD1 is required for chromosome segregation during mitosis. Eur J Cell Biol (2010) 0.91

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. ACS Chem Biol (2012) 0.89

Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J Virol (2008) 0.87

Overexpression of LSD1 in hepatocellular carcinoma: a latent target for the diagnosis and therapy of hepatoma. Tumour Biol (2012) 0.86

Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML. Cancer Cell (2012) 0.84

Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. Cell Cycle (2014) 0.82

Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. ACS Med Chem Lett (2013) 0.79

Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1. FEBS Lett (2012) 0.77