Roles of the intestinal microbiota in pathogen protection.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28243438)

Published in Clin Transl Immunology on February 10, 2017

Authors

Carles Ubeda1, Ana Djukovic2, Sandrine Isaac2

Author Affiliations

1: Departamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain; Centers of Biomedical Research Network (CIBER) in Epidemiology and Public Health, Madrid, Spain.
2: Departamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública - FISABIO , Valencia, Spain.

Articles cited by this

Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med (2013) 20.65

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell (2005) 15.46

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature (2010) 10.34

Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science (2006) 9.95

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol (2007) 7.58

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science (2011) 7.07

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature (2013) 6.45

The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol Microbiol (1998) 6.38

Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature (2010) 6.25

The impact of the gut microbiota on human health: an integrative view. Cell (2012) 6.01

RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol (2008) 5.91

Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature (2011) 5.83

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A (2008) 5.78

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov (2007) 5.65

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature (2014) 5.51

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature (2013) 5.47

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med (2010) 4.98

Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J Clin Invest (2010) 4.95

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature (2008) 4.87

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature (2011) 4.63

Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients. Lancet (1989) 4.44

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature (2013) 4.43

Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe (2009) 4.20

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science (2012) 4.17

Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog (2012) 3.81

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med (2007) 3.79

Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol (2014) 3.77

Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog (2010) 3.76

Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science (2013) 3.54

Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity (2013) 3.51

Members of the human gut microbiota involved in recovery from Vibrio cholerae infection. Nature (2014) 3.50

Culture of previously uncultured members of the human gut microbiota by culturomics. Nat Microbiol (2016) 3.39

The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity (2011) 3.32

The biology of intestinal immunoglobulin A responses. Immunity (2008) 3.18

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science (2014) 3.13

Human commensals producing a novel antibiotic impair pathogen colonization. Nature (2016) 3.03

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99

Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota. Proc Natl Acad Sci U S A (2011) 2.98

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell (2014) 2.97

An enteric virus can replace the beneficial function of commensal bacteria. Nature (2014) 2.80

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity (2013) 2.78

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A (2006) 2.63

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun (2014) 2.39

Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis (2010) 2.26

The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria. Immunity (2014) 2.22

Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA. Mol Microbiol (2002) 2.18

Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation. Nature (2016) 2.17

Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host Microbe (2016) 2.11

Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon. Proc Natl Acad Sci U S A (2010) 2.11

Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe (2013) 2.06

Fucose sensing regulates bacterial intestinal colonization. Nature (2012) 1.89

Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infect Immun (2013) 1.85

Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J Clin Invest (1999) 1.82

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. Cell (2015) 1.76

Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin. Infect Immun (1978) 1.66

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection. Cell Host Microbe (2015) 1.66

Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med (2015) 1.63

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell (2015) 1.63

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol (2012) 1.62

Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe (2014) 1.60

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Butyrate specifically down-regulates salmonella pathogenicity island 1 gene expression. Appl Environ Microbiol (2006) 1.57

Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis. Infect Immun (2011) 1.53

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome. Cell (2016) 1.51

Microcins mediate competition among Enterobacteriaceae in the inflamed gut. Nature (2016) 1.44

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology (2015) 1.42

Gut microbiota-produced succinate promotes C. difficile infection after antibiotic treatment or motility disturbance. Cell Host Microbe (2014) 1.40

Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. J Immunol (2012) 1.34

Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine. PLoS One (2013) 1.34

Antibiotics, microbiota, and immune defense. Trends Immunol (2012) 1.33

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection. Nat Med (2013) 1.30

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop. J Immunol (2012) 1.24

Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract. Nature (2015) 1.19

The microbiota in adaptive immune homeostasis and disease. Nature (2016) 1.18

Meta'omic analytic techniques for studying the intestinal microbiome. Gastroenterology (2014) 1.16

Complementarity and redundancy of IL-22-producing innate lymphoid cells. Nat Immunol (2015) 1.10

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity (2016) 1.05

REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum. Mucosal Immunol (2013) 1.01

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization. Nat Med (2015) 0.99

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization. Cell Host Microbe (2015) 0.95

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell (2016) 0.95

Influence of intestinal anaerobes and organic acids on the growth of enterohaemorrhagic Escherichia coli O157:H7. J Med Microbiol (2002) 0.94

The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nat Microbiol (2016) 0.87

Loss of Vancomycin-Resistant Enterococcus Fecal Dominance in an Organ Transplant Patient With Clostridium difficile Colitis After Fecal Microbiota Transplant. Open Forum Infect Dis (2015) 0.86

Haemolytic uraemic syndrome. J Intern Med (2016) 0.80

TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus. Sci Transl Med (2016) 0.80

Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection. Proc Natl Acad Sci U S A (2016) 0.80

Innate lymphoid cells in intestinal immunity and inflammation. Cell Mol Life Sci (2015) 0.79

Short- and long-term effects of oral vancomycin on the human intestinal microbiota. J Antimicrob Chemother (2016) 0.77