Published in J Biol Chem on September 12, 2016
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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
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The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem (2009) 5.80
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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol (2005) 4.53
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res (2008) 3.56
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Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell (2008) 2.66
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Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res (2011) 2.14
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A mechanism for the suppression of homologous recombination in G1 cells. Nature (2015) 2.06
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell (2009) 1.85
Polyubiquitylation drives replisome disassembly at the termination of DNA replication. Science (2014) 1.80
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. J Biol Chem (2006) 1.78
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem (2006) 1.69
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Subcellular localization and cytoplasmic complex status of endogenous Keap1. Genes Cells (2007) 1.67
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Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66
Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol (2008) 1.61
Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes. Methods Enzymol (2004) 1.53
Regulating DNA replication in eukarya. Cold Spring Harb Perspect Biol (2013) 1.52
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains. Proc Natl Acad Sci U S A (2010) 1.48
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MCM proteins are associated with RNA polymerase II holoenzyme. Mol Cell Biol (1999) 1.35
The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. Proc Natl Acad Sci U S A (2005) 1.35
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. Free Radic Biol Med (2012) 1.18
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. Cell Signal (2010) 1.16
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res (2013) 1.12
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The mechanism of DNA replication termination in vertebrates. Nature (2015) 1.04
Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones. Curr Opin Pharmacol (2009) 1.03
The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. J Biol Chem (2002) 1.02
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res (2013) 1.01
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease. Dis Model Mech (2011) 1.00
Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol Cell (2014) 0.96
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem (2012) 0.95
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Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Mol Cell Proteomics (2015) 0.90
Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase. Curr Biol (2015) 0.90
Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol (2014) 0.89
Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA. Free Radic Biol Med (2012) 0.89
Mcm3 is polyubiquitinated during mitosis before establishment of the pre-replication complex. J Biol Chem (2002) 0.86
The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro. PLoS One (2013) 0.84
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells. Biochem Biophys Res Commun (2013) 0.83
USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol (2016) 0.83
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data. J Proteome Res (2014) 0.77
TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression. Mol Cells (2015) 0.76