Published in J Biol Chem on October 17, 2006
Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal (2010) 3.19
Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog (2009) 2.94
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res (2010) 2.14
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell (2009) 1.85
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res (2008) 1.64
Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicol Sci (2009) 1.54
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest (2011) 1.54
Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway. J Biol Chem (2010) 1.47
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Cell Death Dis (2014) 1.33
The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell Rep (2014) 1.29
Update on the Kelch-like (KLHL) gene family. Hum Genomics (2013) 1.29
Increased cell migration and plasticity in Nrf2-deficient cancer cell lines. Oncogene (2010) 1.26
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc Natl Acad Sci U S A (2009) 1.24
Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. Epigenetics (2011) 1.20
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
Retracted INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis. Cell Death Differ (2010) 1.16
Comparison of Secondary Structure Formation Using 10 Different Force Fields in Microsecond Molecular Dynamics Simulations. J Chem Theory Comput (2012) 1.07
Retracted Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem (2011) 1.07
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. J Biol Chem (2009) 1.02
Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis. J Biol Chem (2009) 0.95
Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death Differ (2014) 0.94
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy (2014) 0.92
Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder. Nat Commun (2014) 0.91
Monitoring Keap1-Nrf2 interactions in single live cells. Biotechnol Adv (2014) 0.91
Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis (2012) 0.90
The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet (2013) 0.90
Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3. Cell Death Dis (2013) 0.90
KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Res (2013) 0.90
The phosphorylation-dependent regulation of mitochondrial proteins in stress responses. J Signal Transduct (2012) 0.89
Phototropism: mechanism and outcomes. Arabidopsis Book (2010) 0.88
Control of cellular Bcl-xL levels by deamidation-regulated degradation. PLoS Biol (2013) 0.86
The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol (2015) 0.86
Atypical protein phosphatases: emerging players in cellular signaling. Int J Mol Sci (2013) 0.86
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. PLoS One (2012) 0.85
The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics. Biochem Soc Trans (2015) 0.84
Protein composition of immunoprecipitated synaptic ribbons. J Proteome Res (2011) 0.83
Innate immune evasion by filoviruses. Virology (2015) 0.82
Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta (2016) 0.82
The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2. Mol Biol Cell (2014) 0.82
Parkin and mitophagy in cancer. Oncogene (2016) 0.81
Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1. J Infect Dis (2015) 0.81
Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis. PLoS One (2016) 0.81
Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response. Antioxid Redox Signal (2014) 0.80
A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5. J Biol Chem (2014) 0.78
6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells. Cell Mol Neurobiol (2015) 0.78
NRF2 induction supporting breast cancer cell survival is enabled by oxidative stress-induced DPP3-KEAP1 interaction. Cancer Res (2017) 0.77
Binding of disordered proteins to a protein hub. Sci Rep (2013) 0.76
Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells. Mol Cell Biol (2016) 0.75
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. J Biol Chem (2016) 0.75
Redox-Related Epigenetic Mechanisms in Glioblastoma: Nuclear Factor (Erythroid-Derived 2)-Like 2, Cobalamin, and Dopamine Receptor Subtype 4. Front Oncol (2017) 0.75
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell Rep (2017) 0.75
Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure (2017) 0.75
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol (2004) 6.93
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol (2003) 6.91
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J (2006) 2.67
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem (2005) 2.45
Crystal structure of the Kelch domain of human Keap1. J Biol Chem (2004) 2.04
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Brain (2010) 1.76
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res (2008) 1.64
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Stem Cells Dev (2008) 1.35
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol (2006) 1.27
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One (2009) 1.24
Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochem Int (2005) 1.14
Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res (2007) 1.11
Effects of interventions on oxidative stress and inflammation of cardiovascular diseases. World J Cardiol (2011) 1.11
Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. PLoS One (2008) 1.10
Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3). Plant Cell (2011) 1.09
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochem J (2009) 1.09
Characterization of the nuclear import and export functions of Ikappa B(epsilon). J Biol Chem (2002) 1.00
Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1. Acta Crystallogr D Biol Crystallogr (2005) 0.99
Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta (2009) 0.95
Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein. Mol Endocrinol (2005) 0.89
Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy. Curr Top Med Chem (2007) 0.89
ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol (2007) 0.87
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Exp Cell Res (2009) 0.87
Gold nanoparticle-mediated detection of circulating cancer cells. Clin Lab Med (2012) 0.86
Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates. J Nucl Med (2008) 0.84
Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene. Bioconjug Chem (2003) 0.84
Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: preparation, characterization, and in vitro mRNA binding. Bioconjug Chem (2002) 0.84
Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development. Adv Drug Deliv Rev (2003) 0.81
Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr (2004) 0.80
Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl (2010) 0.79
CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage. Biol Reprod (2002) 0.78
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2. PLoS One (2012) 0.77