Tissue Immunometabolism: Development, Physiology, and Pathobiology.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27693378)

Published in Cell Metab on September 21, 2016

Authors

Kevin Man1, Vassily I Kutyavin1, Ajay Chawla2

Author Affiliations

1: Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0795, USA.
2: Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0795, USA; Departments of Physiology and Medicine, University of California, San Francisco, CA 94143-0795, USA. Electronic address: ajay.chawla@ucsf.edu.

Articles cited by this

(truncated to the top 100)

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Inflammation and metabolic disorders. Nature (2006) 33.33

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97

Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 23.00

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 17.58

PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev (2000) 9.09

Nuclear receptors and lipid physiology: opening the X-files. Science (2001) 8.76

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A (1999) 7.48

PPARs and the complex journey to obesity. Nat Med (2004) 7.44

Towards a molecular understanding of adaptive thermogenesis. Nature (2000) 7.04

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96

Circadian integration of metabolism and energetics. Science (2010) 6.86

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell (1998) 6.70

The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65

White fat progenitor cells reside in the adipose vasculature. Science (2008) 6.49

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity (2010) 6.48

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab (2006) 6.44

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol (2010) 5.84

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83

The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63

CCAAT-enhancer binding protein: a component of a differentiation switch. Science (1991) 5.61

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53

Brown and beige fat: development, function and therapeutic potential. Nat Med (2013) 5.29

Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29

Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol (2011) 4.72

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature (2011) 4.71

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A (2007) 4.69

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat Cell Biol (2010) 4.57

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature (1999) 4.32

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest (2004) 4.16

Insect fat body: energy, metabolism, and regulation. Annu Rev Entomol (2010) 4.15

What we talk about when we talk about fat. Cell (2014) 4.12

In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab (2012) 3.90

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nat Rev Immunol (2007) 3.88

Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med (2013) 3.86

PPAR gamma and human metabolic disease. J Clin Invest (2006) 3.83

Forging a field: the golden age of iron biology. Blood (2008) 3.83

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature (2014) 3.74

Organogenesis and development of the liver. Dev Cell (2010) 3.71

Nonshivering thermogenesis and its adequate measurement in metabolic studies. J Exp Biol (2011) 3.69

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A (2010) 3.54

Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell (2014) 3.52

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell (2014) 3.44

The worm has turned--microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol (2005) 3.34

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell (2014) 3.27

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell (2014) 3.22

Type 2 innate lymphoid cells control eosinophil homeostasis. Nature (2013) 3.20

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis (2010) 3.12

LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol (2006) 3.11

Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09

A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09

Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell (2013) 3.00

Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol (2003) 2.95

Cellular metabolism and disease: what do metabolic outliers teach us? Cell (2012) 2.90

Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science (2013) 2.85

Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell (2012) 2.81

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med (2013) 2.79

Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell (2014) 2.78

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol (2015) 2.73

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration. Proc Natl Acad Sci U S A (2005) 2.71

Characterization of the adipocyte cellular lineage in vivo. Nat Cell Biol (2013) 2.66

Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell (2014) 2.61

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep (2013) 2.52

Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells (2009) 2.48

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell (2006) 2.45

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab (2014) 2.44

Glutamine metabolism in lymphocytes of the rat. Biochem J (1983) 2.40

Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell (2014) 2.38

Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science (2013) 2.32

The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol (2011) 2.31

Microbiota depletion promotes browning of white adipose tissue and reduces obesity. Nat Med (2015) 2.27

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab (2013) 2.23

Is adipose tissue a place for Mycobacterium tuberculosis persistence? PLoS One (2006) 2.18

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature (2008) 2.18

A smooth muscle-like origin for beige adipocytes. Cell Metab (2014) 2.18

Hormonal regulation of hepatic glucose production in health and disease. Cell Metab (2011) 2.12

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology (2001) 2.11

Metabolic zonation of the liver: regulation and implications for liver function. Pharmacol Ther (1992) 2.02

Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Cell Metab (2009) 2.00

Changes in patterns of enzymes of carbohydrate metabolism in the developing rat liver. J Biol Chem (1963) 1.97

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat Immunol (2014) 1.95

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science (2014) 1.94

Serum lipids in infection. N Engl J Med (1969) 1.93

On the Treatment of Glycosuria and Diabetes Mellitus with Sodium Salicylate. Br Med J (1901) 1.92

Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell Metab (2013) 1.85

EBF2 determines and maintains brown adipocyte identity. Cell Metab (2013) 1.85

Immunological goings-on in visceral adipose tissue. Cell Metab (2013) 1.84

The adipocyte as an important target cell for Trypanosoma cruzi infection. J Biol Chem (2005) 1.82

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling. Proc Natl Acad Sci U S A (2009) 1.79