Published in Cell on January 20, 2012
Necroptosis and its role in inflammation. Nature (2015) 3.01
Necroptosis. N Engl J Med (2014) 2.71
TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell (2013) 2.71
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem (2013) 2.24
Ferroptosis as a p53-mediated activity during tumour suppression. Nature (2015) 2.06
Mitochondrial dynamics in neurodegeneration. Trends Cell Biol (2012) 1.99
RIP3: a molecular switch for necrosis and inflammation. Genes Dev (2013) 1.94
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest (2013) 1.83
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A (2014) 1.78
Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation (2016) 1.74
Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology (2014) 1.73
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature (2013) 1.70
Newly described pattern recognition receptors team up against intracellular pathogens. Nat Rev Immunol (2013) 1.69
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med (2012) 1.68
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov (2013) 1.66
Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol (2012) 1.63
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proc Natl Acad Sci U S A (2013) 1.59
Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep (2013) 1.59
Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron (2014) 1.56
CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One (2013) 1.48
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem (2013) 1.48
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis (2013) 1.46
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci (2012) 1.42
Tumor necrosis factor. Cancer Lett (2012) 1.41
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology (2013) 1.41
Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer (2015) 1.39
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Cell Death Dis (2014) 1.33
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife (2013) 1.28
Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol (2014) 1.27
Die another way--non-apoptotic mechanisms of cell death. J Cell Sci (2014) 1.27
Mitochondria and endothelial function. Circ Res (2013) 1.27
Tubular p53 regulates multiple genes to mediate AKI. J Am Soc Nephrol (2014) 1.26
The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. Immunity (2014) 1.26
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest (2014) 1.23
Viral modulation of programmed necrosis. Curr Opin Virol (2013) 1.20
MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget (2015) 1.17
RIP kinases: key decision makers in cell death and innate immunity. Cell Death Differ (2014) 1.14
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury. Cell Death Dis (2014) 1.14
Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis (2013) 1.13
Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics (2012) 1.13
Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology (2015) 1.11
Mitochondrial dynamics and mitochondrial quality control. Redox Biol (2014) 1.09
TAK1 control of cell death. Cell Death Differ (2014) 1.09
Necroptosis: is there a role for mitochondria? Front Physiol (2014) 1.08
Receptor-mediated mitophagy in yeast and mammalian systems. Cell Res (2014) 1.07
Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. Biochem J (2013) 1.07
Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res (2015) 1.06
Staying alive: cell death in antiviral immunity. Mol Cell (2014) 1.06
A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene (2013) 1.06
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab (2015) 1.05
Programmed necrosis and autophagy in immune function. Immunol Rev (2012) 1.05
New components of the necroptotic pathway. Protein Cell (2012) 1.04
Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease. Br J Pharmacol (2014) 1.04
Necroptosis induced by RIPK3 requires MLKL but not Drp1. Cell Death Dis (2014) 1.04
Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure. FEBS Open Bio (2014) 1.03
Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. Cold Spring Harb Perspect Biol (2012) 1.03
RIP3 finds partners in crime. Cell (2012) 1.02
Functions of BCL-X L at the Interface between Cell Death and Metabolism. Int J Cell Biol (2013) 1.02
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. J Biol Chem (2015) 1.00
Mechanisms of drug-induced liver injury. Clin Liver Dis (2013) 0.99
Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death. Oncogene (2015) 0.99
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. J Biol Chem (2012) 0.98
Structural basis of signal transduction in the TNF receptor superfamily. Adv Immunol (2013) 0.97
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis (2012) 0.97
Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling. Nat Commun (2015) 0.97
Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell (2012) 0.97
New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol (2014) 0.96
Necrosis-dependent and independent signaling of the RIP kinases in inflammation. Cytokine Growth Factor Rev (2013) 0.95
Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. Genes Dev (2013) 0.95
Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv (2016) 0.94
The mechanism of necroptosis in normal and cancer cells. Cancer Biol Ther (2013) 0.93
Cell death-associated molecular-pattern molecules: inflammatory signaling and control. Mediators Inflamm (2014) 0.93
Cell death in the myocardium: my heart won't go on. IUBMB Life (2013) 0.92
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy (2014) 0.92
Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder. Nat Commun (2014) 0.91
MLKL regulates necrotic plasma membrane permeabilization. Cell Res (2014) 0.91
Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res (2013) 0.91
RPE necroptosis in response to oxidative stress and in AMD. Ageing Res Rev (2015) 0.91
The flick of a switch: which death program to choose? Cell Death Differ (2012) 0.90
Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis (2014) 0.90
LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. Cell Death Differ (2014) 0.90
Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis (2012) 0.90
Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3. Cell Death Dis (2013) 0.90
Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ (2015) 0.90
Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective. J Interferon Cytokine Res (2013) 0.89
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J (2014) 0.89
The phosphorylation-dependent regulation of mitochondrial proteins in stress responses. J Signal Transduct (2012) 0.89
Sorafenib-induced defective autophagy promotes cell death by necroptosis. Oncotarget (2015) 0.89
Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. Cell Death Differ (2012) 0.89
Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Cancer Metastasis Rev (2015) 0.89
Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner. Cell Death Differ (2015) 0.88
Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals. Cell Death Dis (2014) 0.87
TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis. Cell Death Dis (2014) 0.86
Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell Death Dis (2013) 0.86
The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol (2015) 0.86
Atypical protein phosphatases: emerging players in cellular signaling. Int J Mol Sci (2013) 0.86
An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nat Biotechnol (2008) 13.96
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
The BioGRID Interaction Database: 2011 update. Nucleic Acids Res (2010) 8.46
Detection of splice junctions from paired-end RNA-seq data by SpliceMap. Nucleic Acids Res (2010) 6.95
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell (2005) 6.86
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
TNF-alpha induces two distinct caspase-8 activation pathways. Cell (2008) 6.81
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell (2005) 6.47
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev (2003) 6.17
Modeling non-uniformity in short-read rates in RNA-Seq data. Genome Biol (2010) 6.10
MADS: a new and improved method for analysis of differential alternative splicing by exon-tiling microarrays. RNA (2008) 5.78
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Cytochrome C-mediated apoptosis. Annu Rev Biochem (2004) 5.38
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37
WormBase: a comprehensive resource for nematode research. Nucleic Acids Res (2009) 5.20
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell (2007) 5.09
Jaundice Constrain or Indication? Response. Radiology (2017) 5.07
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (2004) 4.95
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (2008) 4.71
Identifiability of isoform deconvolution from junction arrays and RNA-Seq. Bioinformatics (2009) 4.32
WormBase: new content and better access. Nucleic Acids Res (2006) 4.01
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell (2009) 3.90
WormBase 2012: more genomes, more data, new website. Nucleic Acids Res (2011) 3.87
Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet (2013) 3.77
Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe (2010) 3.73
WormBase 2007. Nucleic Acids Res (2007) 3.69
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A (2004) 3.63
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science (2013) 3.61
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59
Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors. Prenat Diagn (2012) 3.54
Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics (2003) 3.39
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol (2007) 3.23
The phosphothreonine lyase activity of a bacterial type III effector family. Science (2007) 3.18
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science (2010) 3.13
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity (2012) 3.07
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell (2010) 2.97
Indirect emissions from biofuels: how important? Science (2009) 2.71
Identification of cross-linked peptides from complex samples. Nat Methods (2012) 2.70
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem (2011) 2.63
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro (2005) 2.60
Cross-hybridization modeling on Affymetrix exon arrays. Bioinformatics (2008) 2.54
Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta (2005) 2.46
Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res (2008) 2.40
WormBase 2014: new views of curated biology. Nucleic Acids Res (2013) 2.39
Evolutionary history of GS3, a gene conferring grain length in rice. Genetics (2009) 2.33
Diaphyseal bone formation in murine tibiae in response to knee loading. J Appl Physiol (1985) (2006) 2.32
Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 2.32
The role of oxygen during fracture healing. Bone (2012) 2.21
How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin (Shanghai) (2008) 2.19
Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc Natl Acad Sci U S A (2005) 2.18
Non-optimal codon usage affects expression, structure and function of clock protein FRQ. Nature (2013) 2.15
Comprehensive comparison of three commercial human whole-exome capture platforms. Genome Biol (2011) 2.15
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature (2013) 2.07
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A (2011) 2.06
The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature (2007) 1.95
Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe (2009) 1.93
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (2008) 1.90
Risk factors for severe illness with 2009 pandemic influenza A (H1N1) virus infection in China. Clin Infect Dis (2011) 1.87
2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers. Mol Cell Proteomics (2002) 1.85
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77
HIV/STD prevalence among men who have sex with men in Chengdu, China and associated risk factors for HIV infection. J Acquir Immune Defic Syndr (2010) 1.76
Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly. Nature (2012) 1.75
Cytokines in alcoholic liver disease. Arch Toxicol (2012) 1.74
Laparoscopy versus open distal gastrectomy for advanced gastric cancer: a systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech (2013) 1.72
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature (2013) 1.70
A strategy for ZnO nanorod mediated multi-mode cancer treatment. Biomaterials (2010) 1.70
Silica encapsulation of n-octadecane via sol-gel process: a novel microencapsulated phase-change material with enhanced thermal conductivity and performance. J Colloid Interface Sci (2009) 1.67
Proteomics of human breast ductal carcinoma in situ. Cancer Res (2002) 1.62
Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A (2011) 1.62
Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol (2002) 1.61
A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature (2012) 1.60
Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat Cell Biol (2012) 1.60
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy (2010) 1.58
Fast and accurate read alignment for resequencing. Bioinformatics (2012) 1.58
A Bayesian connectivity-based approach to constructing probabilistic gene regulatory networks. Bioinformatics (2004) 1.57
Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol (2011) 1.55