Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.

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Published in PLoS Genet on October 21, 2016

Authors

Christoph Nowak1, Samira Salihovic1, Andrea Ganna2,3,4,5, Stefan Brandmaier6,7, Taru Tukiainen8, Corey D Broeckling9, Patrik K Magnusson5, Jessica E Prenni9, Rui Wang-Sattler6,7,10, Annette Peters7,10,11, Konstantin Strauch12,13, Thomas Meitinger14,15, Vilmantas Giedraitis16, Johan Ärnlöv17,18, Christian Berne19, Christian Gieger6,7,10, Samuli Ripatti8,20,21, Lars Lind18, Nancy L Pedersen5, Johan Sundström18, Erik Ingelsson1,22, Christoph Nowak1

Author Affiliations

1: Department of Medical Sciences and Science for Life Laboratory, Molecular Epidemiology Unit, Uppsala University, Uppsala, Sweden.
2: Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States of America.
3: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA,United States of America.
4: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.
5: Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, Stockholm, Sweden.
6: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, München-Neuherberg, Germany.
7: Institute of Epidemiology II, Helmholtz Zentrum München, München-Neuherberg, Germany.
8: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
9: Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, Colorado, United States of America.
10: German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
11: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America.
12: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
13: Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.
14: Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
15: Institute of Human Genetics, Technische Universität München, Munich, Germany.
16: Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
17: School of Health and Social Studies, Dalarna University, Falun, Sweden.
18: Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
19: Department of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.
20: Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
21: Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
22: Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States of America.

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