Published in Proc Natl Acad Sci U S A on July 01, 1978
Opioid peptides and alpha-melanocyte-stimulating hormone in genetically obese (ob/ob) mice during development. Proc Natl Acad Sci U S A (1979) 0.83
Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature (1975) 10.33
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary. Proc Natl Acad Sci U S A (1977) 1.74
Regional distribution of LEU and MET enkephalin in rat brain. Neuropharmacology (1977) 1.43
Evidence for a long Leu-enkephalin striopallidal pathway in rat brain. Nature (1978) 1.21
Determination of methionine enkephalin in discrete regions of rat brain. Brain Res (1977) 1.12
Release of enkephalin from rat globus pallidus in vitro. Nature (1978) 1.00
In vitro release of Leu- and Met-enkephalin from the corpus striatum. Nature (1978) 0.94
Radioimmunoassay of brain peptides: evaluation of a methodology for the assay of beta-endorphin and enkephalin. Life Sci (1977) 0.93
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32
Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem (1966) 7.91
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science (1973) 7.47
The uptake of [3H]GABA by slices of rat cerebral cortex. J Neurochem (1968) 5.05
Cellular and molecular mechanisms of drug dependence. Science (1988) 4.99
Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proc Natl Acad Sci U S A (1985) 4.60
The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol (1989) 4.36
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci (1981) 4.15
Common precursor to corticotropins and endorphins. Proc Natl Acad Sci U S A (1977) 3.99
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A (1986) 3.97
Molecular and physiological diversity of cortical nonpyramidal cells. J Neurosci (1997) 3.86
Role of transmitter uptake mechanisms in synaptic neurotransmission. Br J Pharmacol (1971) 3.82
Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science (1997) 3.68
Neuroscience of addiction. Neuron (1998) 3.60
National character does not reflect mean personality trait levels in 49 cultures. Science (2005) 3.56
Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. J Neurochem (1970) 3.42
Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci U S A (1986) 3.42
The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. Br J Pharmacol (1969) 3.25
Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science (1982) 3.10
Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart. Br J Pharmacol (1970) 3.07
Just a minute, please. Science (1999) 2.93
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol Rev (1983) 2.92
Posttranslational glutamylation of alpha-tubulin. Science (1990) 2.83
Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther (1993) 2.79
Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature (1977) 2.74
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science (1977) 2.68
The retrograde axonal transport of nerve growth factor. Brain Res (1974) 2.60
Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Annu Rev Neurosci (1979) 2.51
Modulation of early sensory processing in human auditory cortex during auditory selective attention. Proc Natl Acad Sci U S A (1993) 2.48
Release of gamma-aminobutyric acid from inhibitory nerves of lobster. Proc Natl Acad Sci U S A (1966) 2.47
Isolation and partial molecular characterization of pituitary fibroblast growth factor. Proc Natl Acad Sci U S A (1984) 2.46
Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci (1981) 2.45
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
AMPA receptor subunits expressed by single Purkinje cells. Neuron (1992) 2.41
Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature (1986) 2.37
Multiple opiate receptor sites on primary afferent fibres. Nature (1980) 2.34
Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis. J Pharmacol Exp Ther (1965) 2.31
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature (1996) 2.30
[Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin]. C R Acad Sci Hebd Seances Acad Sci D (1976) 2.22
The possible existence of multiple receptors for substance P. Naunyn Schmiedebergs Arch Pharmacol (1982) 2.18
Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta. Nature (1986) 2.17
Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology (Berl) (1984) 2.13
The importance of reviewers. Science (1999) 2.11
Culture of enzymatically dispersed pituitary cells: functional validation of a method. Endocrinology (1972) 2.09
Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells in vitro: implications for a role of heparinase-like enzymes in the neovascular response. Biochem Biophys Res Commun (1987) 2.08
Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. Am J Hum Genet (2007) 2.06
Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc Natl Acad Sci U S A (1980) 2.05
Classification of fusiform neocortical interneurons based on unsupervised clustering. Proc Natl Acad Sci U S A (2000) 2.03
A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature (1993) 2.03
The physiologic disposition and metabolism of norepinephrine in immunosympathectomized animals. J Pharmacol Exp Ther (1966) 2.03
Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides. Cell (1983) 2.01
GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors. J Neurochem (1971) 2.00
Trans-synaptic regulation of growth and development of adrenergic neurones in a mouse sympathetic ganglion. Brain Res (1971) 1.99
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A (1988) 1.99
Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. Proc Natl Acad Sci U S A (1978) 1.98
Widespread distribution of protein I in the central and peripheral nervous systems. Proc Natl Acad Sci U S A (1979) 1.98
Common 82-nucleotide sequence unique to brain RNA. Proc Natl Acad Sci U S A (1982) 1.98
Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain. Proc Natl Acad Sci U S A (1979) 1.96
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci (1996) 1.95
Release of dopamine from dendrites in rat substantia nigra. Nature (1976) 1.95
Meta-analysis of P300 amplitude from males at risk for alcoholism. Psychol Bull (1994) 1.93
Reduced uptake of tritiated noradrenaline in tissues of immunosympathectomized animals. Nature (1965) 1.91
Identification of sleep-promoting neurons in vitro. Nature (2000) 1.90
Autoradiographic localization of 3 H-GABA in rat retina. Nat New Biol (1972) 1.90
The formation of synaptic junctions in developing rat brain: a quantitative electron microscopic study. Brain Res (1967) 1.90
Effects of phenoxybenzamine on the uptake and metabolism of noradrenaline in the rat heart and vas deferens. Br J Pharmacol (1969) 1.90
Receptor- and heparin-binding domains of basic fibroblast growth factor. Proc Natl Acad Sci U S A (1988) 1.87
Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration. J Immunol (1998) 1.87
Multiple tachykinin binding sites in peripheral tissues and in brain. Eur J Pharmacol (1986) 1.86
Catecholamine uptake processes. Br Med Bull (1973) 1.83
Uptake and metabolism of gamma-aminobutyric acid by neurones and glial cells. Biochem Pharmacol (1975) 1.83
The inhibition of noradrenaline uptake by drugs. Adv Drug Res (1965) 1.82
Use of catechol O-methyltransferase for the enzyme radiochemical assay of dopamine. J Neurochem (1973) 1.82
Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension. Proc Natl Acad Sci U S A (1986) 1.82
An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin. Science (1980) 1.81
Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity. Proc Natl Acad Sci U S A (1976) 1.80
Capsaicin-induced depletion of substance P from primary sensory neurones. Brain Res (1978) 1.80
beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. Proc Natl Acad Sci U S A (1976) 1.79
Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc Natl Acad Sci U S A (1994) 1.79
Dopamine receptors in the brain. Science (1975) 1.79
Neurochemical characteristics of early and late onset types of Alzheimer's disease. Br Med J (Clin Res Ed) (1984) 1.78
Locating the central sulcus: comparison of MR anatomic and magnetoencephalographic functional methods. AJNR Am J Neuroradiol (1993) 1.76
Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Psychopharmacology (Berl) (1982) 1.76
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary. Proc Natl Acad Sci U S A (1977) 1.74