Published in Proc Natl Acad Sci U S A on October 31, 2016
Fresh Ideas, Foundational Experiments (FIFE): Immunology and Diabetes 2016 FIFE Symposium. Front Endocrinol (Lausanne) (2017) 0.75
The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population. Inflamm Res (2017) 0.75
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 20.00
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet (2004) 12.25
T cell exhaustion. Nat Immunol (2011) 11.08
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J Exp Med (2003) 11.08
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 10.66
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol (2008) 10.26
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol (1994) 10.03
Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med (2000) 9.36
Interleukin-10 determines viral clearance or persistence in vivo. Nat Med (2006) 8.01
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood (2009) 6.17
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet (2005) 5.00
Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med (2006) 4.97
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34
Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science (2013) 4.18
Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14
Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J Virol (1995) 3.90
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res (2004) 3.59
Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol (1998) 3.52
PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science (2004) 3.34
Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell (1993) 2.84
Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. J Virol (2005) 2.75
Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol (2015) 2.74
More is better: activators and repressors from the same gene. Cell (1992) 2.56
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med (2011) 2.48
The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet (2011) 2.48
Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J Virol (2003) 2.36
Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem (2006) 2.29
Immune therapy of a persistent and disseminated viral infection. J Virol (1987) 2.24
PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol (2009) 1.79
The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses. Curr Opin Immunol (2009) 1.71
Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunol (2001) 1.68
Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A (2011) 1.62
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity (2013) 1.49
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med (2012) 1.43
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J Clin Invest (2013) 1.42
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest (2013) 1.37
The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy. J Immunol (1999) 1.19
Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol (2013) 1.14
PTPN22 alters the development of regulatory T cells in the thymus. J Immunol (2012) 1.13
Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J Biol Chem (1998) 1.10
CD8 T cell exhaustion in human visceral leishmaniasis. J Infect Dis (2013) 1.06
Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol (2012) 1.05
Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci Signal (2012) 1.05
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat Immunol (2014) 1.02
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection. Cell Host Microbe (2015) 1.01
Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii. Immunology (2010) 1.00
Genetic influence of PTPN22 R620W polymorphism in tuberculosis. Hum Immunol (2006) 1.00
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells. J Immunol (2014) 1.00
The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol (2008) 0.99
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J Clin Invest (2014) 0.96
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Hum Immunol (2013) 0.87
CREM: a master-switch in the transcriptional response to cAMP. Philos Trans R Soc Lond B Biol Sci (1996) 0.85
Early virus-host interactions dictate the course of a persistent infection. PLoS Pathog (2015) 0.82
Homeostatic proliferation of mature T cells. Methods Mol Biol (2013) 0.81
Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells? Nat Immunol (2010) 0.81
The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus. Clin Immunol (2014) 0.78
Retroviral vector expression in TCR transgenic CD4⁺ T cells. Methods Mol Biol (2015) 0.78
IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling. J Immunol (2015) 0.76
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells. J Immunol (2014) 1.00
Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanisms. J Immunol (2014) 0.80
Using Autoimmunity To Inform Tumor Immunity. J Immunol (2015) 0.75