Cyclic GMP synthesis and function.

PubWeight™: 4.89‹?› | Rank: Top 1%

🔗 View Article (PMID 2827195)

Published in Pharmacol Rev on September 01, 1987

Authors

S A Waldman1, F Murad

Author Affiliations

1: Department of Medicine, Stanford University School of Medicine, California.

Articles citing this

(truncated to the top 100)

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A (1989) 7.79

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 4.50

L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br J Pharmacol (1990) 2.84

A cell culture model of the blood-brain barrier. J Cell Biol (1991) 2.35

Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator. Br J Pharmacol (1988) 2.32

Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A (2007) 2.24

Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J (1996) 2.13

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism. EMBO J (2007) 2.08

Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase. EMBO J (1994) 2.06

Electronic configuration assignment and the importance of low-lying excited states in high-spin imidazole-ligated iron(II) porphyrinates. J Am Chem Soc (2005) 2.03

Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction. EMBO J (1989) 1.74

Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest (2006) 1.69

Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest (1998) 1.62

Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase. Proc Natl Acad Sci U S A (1994) 1.58

Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme. J Cell Biol (2001) 1.58

NO activation of guanylyl cyclase. EMBO J (2004) 1.50

Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses. Proc Natl Acad Sci U S A (2000) 1.49

YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br J Pharmacol (1995) 1.39

An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol (1992) 1.33

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose. Br J Pharmacol (2010) 1.31

Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem J (1998) 1.27

N-methylhydroxylamine inhibits and M&B 22948 potentiates relaxations of the mouse anococcygeus to non-adrenergic, non-cholinergic field stimulation and to nitrovasodilator drugs. Br J Pharmacol (1989) 1.25

Potentiation by cyclic GMP of beta-adrenergic effect on Ca2+ current in guinea-pig ventricular cells. J Physiol (1991) 1.20

Bioassay of nitric oxide released upon stimulation of non-adrenergic non-cholinergic nerves in the canine ileocolonic junction. Br J Pharmacol (1991) 1.17

Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol (1999) 1.13

Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc Natl Acad Sci U S A (1991) 1.12

The shaping of nitric oxide signals by a cellular sink. J Physiol (2001) 1.11

Signal transduction by cGMP in heart. Basic Res Cardiol (1992) 1.09

Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br J Pharmacol (1999) 1.08

Superoxide-dependent consumption of nitric oxide in biological media may confound in vitro experiments. Biochem J (2003) 1.07

Augmentation of the natriuretic activity of exogenous and endogenous atriopeptin in rats by inhibition of guanosine 3',5'-cyclic monophosphate degradation. J Clin Invest (1990) 1.07

Erythrocyte stages of Plasmodium falciparum exhibit a high nitric oxide synthase (NOS) activity and release an NOS-inducing soluble factor. J Exp Med (1995) 1.06

Nitroglycerin relaxes canine coronary arterial smooth muscle without reducing intracellular Ca2+ concentrations measured with fura-2. Br J Pharmacol (1989) 1.06

S-nitrosocysteine, but not sodium nitroprusside, produces apamin-sensitive hyperpolarization in rat gastric fundus. Br J Pharmacol (1993) 1.05

Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition. Proc Natl Acad Sci U S A (2003) 1.05

The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators. Mol Cell Biol (1992) 1.04

Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta. Br J Pharmacol (1996) 1.04

Action of calcitonin gene-related peptide upon bovine vascular endothelial and smooth muscle cells grown in isolation and co-culture. Br J Pharmacol (1990) 1.03

Distribution of heat-stable enterotoxin/guanylin receptors in the intestinal tract of man and other mammals. J Anat (1994) 1.02

Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin. Br J Pharmacol (1992) 1.01

Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells. Br J Pharmacol (1996) 1.00

Endothelium-dependent and -independent effects of exogenous ATP, adenosine, GTP and guanosine on vascular tone and cyclic nucleotide accumulation of rat mesenteric artery. Br J Pharmacol (1992) 0.99

Actions of hydrogen sulphide on ion transport across rat distal colon. Br J Pharmacol (2009) 0.99

Variable potency of nitrergic-nitrovasodilator relaxations of the mouse anococcygeus against different forms of induced tone. Br J Pharmacol (1994) 0.98

The role of nitric oxide in inhibitory non-adrenergic non-cholinergic neurotransmission in the canine lower oesophageal sphincter. Br J Pharmacol (1991) 0.98

Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species. Br J Pharmacol (2007) 0.98

Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus. Br J Pharmacol (1994) 0.97

Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration. Biochem J (2007) 0.96

Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine. J Gen Physiol (1994) 0.96

Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep. J Physiol (2003) 0.93

Iron-sulphur cluster nitrosyls, a novel class of nitric oxide generator: mechanism of vasodilator action on rat isolated tail artery. Br J Pharmacol (1992) 0.92

Recurrent acute respiratory tract infections in areas with high nitrate concentrations in drinking water. Environ Health Perspect (2000) 0.92

Heme-dependent and independent soluble guanylate cyclase activators and vasodilation. J Cardiovasc Pharmacol (2010) 0.91

Modulation by endothelium of the responses induced by endothelin-1 and by some of its analogues in rat isolated aorta. Br J Pharmacol (1991) 0.91

Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. J Med Chem (2007) 0.91

The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol Cell Biochem (1993) 0.90

Propofol stimulates nitric oxide release from cultured porcine aortic endothelial cells. Br J Pharmacol (1993) 0.90

Tissues cIMPly do not lie. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.88

Attenuation of vasoconstriction by endogenous nitric oxide in rat caudal artery. Br J Pharmacol (1992) 0.88

Interactions of iloprost and sodium nitroprusside on vascular smooth muscle and platelet aggregation. Br J Pharmacol (1989) 0.88

Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells. Biochem J (1990) 0.87

Inhibitory effects of guanosine 3':5'-cyclic monophosphate on the synthesis of dopamine in the rat kidney. Br J Pharmacol (1991) 0.87

Sodium nitroprusside alters Ca2+ flux components and Ca2(+)-dependent fluxes of K+ and Cl- in rat aorta. J Physiol (1990) 0.87

ATP and nitric oxide: inhibitory NANC neurotransmitters in the longitudinal muscle-myenteric plexus preparation of the rat ileum. Br J Pharmacol (1996) 0.86

RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase. Nitric Oxide (2011) 0.86

Effects of zaprinast and rolipram on platelet aggregation and arrhythmias following myocardial ischaemia and reperfusion in anaesthetized rabbits. Br J Pharmacol (1991) 0.86

Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil. Br J Pharmacol (1990) 0.85

Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta. Br J Pharmacol (1995) 0.85

The adventitia may be a barrier specific to nitric oxide in rabbit pulmonary artery. J Clin Invest (1994) 0.85

cGMP induces phase shifts of a mammalian circadian pacemaker at night, in antiphase to cAMP effects. Proc Natl Acad Sci U S A (1989) 0.84

From synaptically localized to volume transmission by nitric oxide. J Physiol (2015) 0.84

Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism. Connection with amplified cytokine release. J Clin Invest (1992) 0.84

Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus. Br J Pharmacol (2000) 0.84

Does cyclic guanosine monophosphate mediate noradrenaline-induced inhibition of islet insulin secretion stimulated by glucose and palmitate? Biochem J (1991) 0.83

Developmental changes in beta-adrenergic and cholinergic interactions on calcium-dependent slow action potentials in rat ventricular muscles. Br J Pharmacol (1990) 0.83

Activation of particulate guanylate cyclase by Escherichia coli heat-stable enterotoxin is regulated by adenine nucleotides. Infect Immun (1991) 0.83

Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells. Stem Cells Dev (2010) 0.82

Endothelin and a Ca2+ ionophore raise cyclic GMP levels in a neuronal cell line via formation of nitric oxide. Br J Pharmacol (1990) 0.82

Vasodilator responses of rat isolated tail artery enhanced by oxygen- dependent, photochemical release of nitric oxide from iron-sulphur-nitrosyls. Br J Pharmacol (1996) 0.82

Influence of a glycine or proline substitution on the functional properties of a 14-amino-acid analog of Escherichia coli heat-stable enterotoxin. Infect Immun (1989) 0.82

Heterogeneity of intestinal receptors for Escherichia coli heat-stable enterotoxin. Infect Immun (1990) 0.82

Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus. Br J Pharmacol (1995) 0.82

Stimulation of soluble guanylate cyclase by superoxide dismutase is mediated by NO. Biochem J (1998) 0.81

Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase. Br J Pharmacol (2013) 0.81

Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad. J Cardiovasc Pharmacol (2015) 0.81

Comparative effects of activation of soluble and particulate guanylyl cyclase on cyclic GMP elevation and relaxation of bovine tracheal smooth muscle. Br J Pharmacol (1995) 0.81

Oxygen binding and redox properties of the heme in soluble guanylate cyclase: implications for the mechanism of ligand discrimination. J Biol Chem (2011) 0.81

Effect of alpha-human atrial natriuretic peptide on the synthesis of dopamine in the rat kidney. Br J Pharmacol (1992) 0.81

Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea. J Physiol (1995) 0.80

Differential effects of lumenal L-arginine and NG-nitro L-arginine on blood flow and water fluxes in rat ileum. Br J Pharmacol (1994) 0.80

The effect of isoenzyme-selective PDE inhibitors on methacholine-induced contraction of guinea-pig and rat ileum. Br J Pharmacol (1996) 0.80

Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat. Br J Pharmacol (1990) 0.80

Photon pharmacology of an iron-sulphur cluster nitrosyl compound acting on smooth muscle. Br J Pharmacol (1994) 0.80

The inhibitory effect of 3-amino-1,2,4-triazole on relaxation induced by hydroxylamine and sodium azide but not hydrogen peroxide or glyceryl trinitrate in rat aorta. Br J Pharmacol (1995) 0.80

Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside. Br J Pharmacol (1994) 0.80

Selective anti-platelet aggregation synergism between a prostacyclin-mimetic, RS93427 and the nitrodilators sodium nitroprusside and glyceryl trinitrate. Br J Pharmacol (1989) 0.80

NO decreases evoked quantal ACh release at a synapse of Aplysia by a mechanism independent of Ca2+ influx and protein kinase G. J Physiol (1996) 0.80

Acute effects of sildenafil on Humphrey visual field and intraocular pressure. Int Ophthalmol (2004) 0.80

Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension. PLoS One (2013) 0.79

Relaxation of guinea-pig trachea by sodium nitroprusside: cyclic GMP and nitric oxide not involved. Br J Pharmacol (1996) 0.79

Articles by these authors

(truncated to the top 100)

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res (1983) 6.42

Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A (1977) 4.90

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 4.50

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res (1977) 3.70

Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature (1978) 3.60

Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest (1986) 3.59

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 3.15

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature (1984) 2.77

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc Natl Acad Sci U S A (1991) 2.58

Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: studies of tissue specificity, potential receptors, and intermediates. J Infect Dis (1980) 2.52

Nobel laureates' letter to President Bush. Washington Post (2001) 2.43

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv Cyclic Nucleotide Res (1978) 2.43

N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation. Eur J Pharmacol (1990) 2.40

Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol (1991) 2.34

Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. J Cyclic Nucleotide Protein Phosphor Res (1983) 2.34

Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proc Natl Acad Sci U S A (1984) 2.26

Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science (1992) 2.25

Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. J Biol Chem (1984) 2.15

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett (1993) 2.14

Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol (2001) 2.08

Regulation of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate levels and contractility in bovine tracheal smooth muscle. Mol Pharmacol (1977) 1.98

Regulation of glycogen metabolism in polymorphonuclear leukocytes. J Biol Chem (1970) 1.98

Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci U S A (1992) 1.93

Activation of guanylate cyclase from rat liver and other tissues by sodium azide. J Biol Chem (1975) 1.77

Evidence for two different forms of guanylate cyclase in rat heart. J Biol Chem (1974) 1.68

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J Histochem Cytochem (1992) 1.65

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol Pharmacol (1992) 1.63

Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochem Biophys Res Commun (1990) 1.61

Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J Immunol (2000) 1.59

Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. J Biol Chem (1986) 1.58

A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. Proc Natl Acad Sci U S A (1971) 1.57

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues. J Cyclic Nucleotide Res (1977) 1.57

Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation. Proc Natl Acad Sci U S A (1977) 1.49

An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci U S A (1998) 1.49

Effects of lipolytic and antilipolytic agents on cyclic 3',5'-adenosine monophosphate in fat cells. J Biol Chem (1971) 1.49

A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts. Am J Physiol (1991) 1.47

Reversible inactivation of guanylate cyclase by mixed disulfide formation. J Biol Chem (1981) 1.46

NO, nitrotyrosine, and cyclic GMP in signal transduction. Med Sci Monit (2001) 1.42

Nonenzymatic formation of guanosine 3':5'-monophosphate from guanosine triphosphate. J Biol Chem (1974) 1.42

Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin. Mol Pharmacol (1990) 1.41

Colocalization of nitric oxide synthase and NADPH-diaphorase in the myenteric plexus of the rat gut. Neurosci Lett (1992) 1.40

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase. Biochem Biophys Res Commun (1991) 1.39

Characterization of protein inhibitors of guanylate cyclase activation from rat heart and bovine lung. J Biol Chem (1978) 1.37

Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. J Biol Chem (1990) 1.34

Cyclic nucleotide levels in incubations of guinea pig trachea. Biochim Biophys Acta (1974) 1.30

Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol (1993) 1.29

Soluble guanylate cyclase from rat lung exists as a heterodimer. J Biol Chem (1986) 1.28

Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. J Cardiovasc Pharmacol (1987) 1.27

Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. Eur J Pharmacol (1985) 1.27

Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proc Natl Acad Sci U S A (1982) 1.26

Nitric oxide and cGMP signaling. Adv Pharmacol (1995) 1.26

Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells. J Biol Chem (1990) 1.26

Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. Br J Pharmacol (1991) 1.25

Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochem Pharmacol (1986) 1.24

Glyceryl trinitrate-induced desensitization of guanylate cyclase in cultured rat lung fibroblasts. J Pharmacol Exp Ther (1988) 1.23

Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Trans Assoc Am Physicians (1983) 1.22

Effects of guanosine 3',5'-monophosphate on glycerol production and accumulation of adenosine 3',5'-monophosphate by fat cells. J Biol Chem (1970) 1.21

Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP. Adv Cyclic Nucleotide Res (1979) 1.21

Effects of decapitation, ether and pentobarbital on guanosine 3',5'-phosphate and adenosine 3',5'-phosphate levels in rat tissues. Biochim Biophys Acta (1974) 1.20

Increases in cyclic GMP levels in brain and liver with sodium azide an activator of guanylate cyclase. Nature (1975) 1.17

Increased particulate and decreased soluble guanylate cyclase activity in regenerating liver, fetal liver, and hepatoma. Proc Natl Acad Sci U S A (1975) 1.17

Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase. Am J Physiol Heart Circ Physiol (2001) 1.17

Human recombinant soluble guanylyl cyclase: expression, purification, and regulation. Proc Natl Acad Sci U S A (2000) 1.16

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc Natl Acad Sci U S A (2001) 1.15

Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate. N Engl J Med (1972) 1.15

Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells. J Biol Chem (1986) 1.15

Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. J Am Soc Nephrol (2001) 1.14

Cellular signaling with nitric oxide and cyclic guanosine monophosphate. Semin Perinatol (2000) 1.14

Interaction of polymorphonuclear neutrophils with Escherichia coli. Effect of enterotoxin on phagocytosis, killing, chemotaxis, and cyclic AMP. J Clin Invest (1978) 1.13

Ca2+/calmodulin-dependent NO synthase type I: a biopteroflavoprotein with Ca2+/calmodulin-independent diaphorase and reductase activities. Biochemistry (1992) 1.13

ANP relaxes bovine tracheal smooth muscle and increases cGMP. Am J Physiol (1989) 1.12

Nitric oxide and cyclic GMP signaling. Proc Soc Exp Biol Med (1996) 1.12

Expression of soluble guanylate cyclase activity requires both enzyme subunits. Biochem Biophys Res Commun (1991) 1.12

Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. Proc Natl Acad Sci U S A (2003) 1.11

Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine. J Biol Chem (1986) 1.11

Inhibition of Escherichia coli heat-stable enterotoxin by indomethacin and chlorpromazine. Infect Immun (1980) 1.11

Adenyl cyclase activity in particles from fat cells. Biochemistry (1969) 1.10

Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circ Res (1984) 1.10

Requirement for a macromolecular factor for sodium azide activation of guanulate cyclase. J Cyclic Nucleotide Res (1975) 1.10

Properties and oxidative regulation of guanylate cyclase. J Cyclic Nucleotide Res (1977) 1.09

Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors. Br J Pharmacol (1993) 1.08

Assay of cyclic nucleotides by receptor protein binding displacement. Methods Enzymol (1974) 1.08

Biochemical mechanisms underlying vascular smooth muscle relaxation: the guanylate cyclase-cyclic GMP system. J Cardiovasc Pharmacol (1988) 1.08

Clinical studies and applications of cyclic nucleotides. Adv Cyclic Nucleotide Res (1973) 1.07

Two forms of guanylate cyclase in mammalian tissues and possible mechanisms for their regulation. Metabolism (1975) 1.07

Endothelial cells have a particulate enzyme system responsible for EDRF formation: measurement by vascular relaxation. Biochem Biophys Res Commun (1991) 1.06

The 1996 Albert Lasker Medical Research Awards. Signal transduction using nitric oxide and cyclic guanosine monophosphate. JAMA (1996) 1.06

Purification of soluble guanylate cyclase from rat liver. Proc Natl Acad Sci U S A (1979) 1.06

Purification and properties of a protein required for sodium azide activation of guanylate cyclase. J Biol Chem (1977) 1.05

Forskolin, phosphodiesterase inhibitors, and cyclic AMP analogs inhibit proliferation of cultured bovine aortic endothelial cells. J Cell Physiol (1986) 1.05

Effects of thiols, sugars, and proteins on nitric oxide activation of guanylate cyclase. J Biol Chem (1979) 1.05

Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. Eur J Pharmacol (1985) 1.05

Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. Biochim Biophys Acta (1986) 1.04

Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circ Res (1985) 1.04

Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta. Br J Pharmacol (1996) 1.04

Ca2+/calmodulin-regulated nitric oxide synthases. Cell Calcium (1992) 1.03

Formation of adenosine 3':5'-monophosphate by preparations of guanylate cyclase from rat liver and other tissues. J Biol Chem (1977) 1.03

Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Biochem Biophys Res Commun (1988) 1.03

Effects of cyclic GMP on smooth muscle relaxation. Adv Pharmacol (1994) 1.02

Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription. Proc Natl Acad Sci U S A (1995) 1.02