An RNA sequence of hundreds of nucleotides at the 5' end of poliovirus RNA is involved in allowing viral protein synthesis.

PubWeight™: 3.93‹?› | Rank: Top 1%

🔗 View Article (PMC 253378)

Published in J Virol on July 01, 1988

Authors

D Trono1, R Andino, D Baltimore

Author Affiliations

1: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.

Articles citing this

The scanning model for translation: an update. J Cell Biol (1989) 31.23

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo. J Virol (1989) 7.01

Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA. EMBO J (1993) 6.29

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J Virol (1993) 6.11

Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region. J Virol (1990) 4.28

Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism. EMBO J (1990) 3.92

Conservation of the secondary structure elements of the 5'-untranslated region of cardio- and aphthovirus RNAs. Nucleic Acids Res (1989) 3.81

The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro. J Virol (1991) 2.83

Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Proc Natl Acad Sci U S A (1996) 2.82

Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies. J Virol (1991) 2.75

5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis. EMBO J (2001) 2.67

Cell proteins bind to multiple sites within the 5' untranslated region of poliovirus RNA. Proc Natl Acad Sci U S A (1989) 2.65

An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells. J Virol (1991) 2.63

Mutational analysis of upstream AUG codons of poliovirus RNA. J Virol (1988) 2.55

Interactions of viral protein 3CD and poly(rC) binding protein with the 5' untranslated region of the poliovirus genome. J Virol (2000) 2.48

A human cell factor is essential for HIV-1 Rev action. EMBO J (1990) 2.43

Construction of less neurovirulent polioviruses by introducing deletions into the 5' noncoding sequence of the genome. J Virol (1989) 2.19

In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region. J Virol (1991) 2.08

Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited. Proc Natl Acad Sci U S A (1989) 2.00

Substitutions in the protease (3Cpro) gene of poliovirus can suppress a mutation in the 5' noncoding region. J Virol (1990) 1.96

Replication of poliovirus RNA and subgenomic RNA transcripts in transfected cells. J Virol (1992) 1.88

Conservation of RNA-protein interactions among picornaviruses. J Virol (1992) 1.81

The deletion of 41 proximal nucleotides reverts a poliovirus mutant containing a temperature-sensitive lesion in the 5' noncoding region of genomic RNA. J Virol (1989) 1.80

Clustered charged-to-alanine mutagenesis of poliovirus RNA-dependent RNA polymerase yields multiple temperature-sensitive mutants defective in RNA synthesis. J Virol (1994) 1.79

Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2. J Virol (1989) 1.77

Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency. J Virol (1992) 1.74

A new cis-acting element for RNA replication within the 5' noncoding region of poliovirus type 1 RNA. J Virol (1995) 1.70

In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus. J Virol (1994) 1.69

Cellular proteins bind to the 3' end of Sindbis virus minus-strand RNA. J Virol (1992) 1.63

Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta (2009) 1.62

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs. Mol Cell Biol (1992) 1.61

A complex RNA sequence determines the internal initiation of encephalomyocarditis virus RNA translation. Nucleic Acids Res (1991) 1.61

Dual initiation sites of protein synthesis on foot-and-mouth disease virus RNA are selected following internal entry and scanning of ribosomes in vivo. EMBO J (1992) 1.60

Intracellular modifications induced by poliovirus reduce the requirement for structural motifs in the 5' noncoding region of the genome involved in internal initiation of protein synthesis. J Virol (1992) 1.60

Echovirus 22 is an atypical enterovirus. J Virol (1990) 1.55

Nucleotide sequences important for translation initiation of enterovirus RNA. J Virol (1991) 1.53

Conserved tertiary structural elements in the 5' nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs. Nucleic Acids Res (1993) 1.46

Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus. Mol Cell Biol (1992) 1.46

Bovine leukemia virus RNA sequences involved in dimerization and specific gag protein binding: close relation to the packaging sites of avian, murine, and human retroviruses. J Virol (1993) 1.43

Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA. J Virol (1995) 1.34

The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent. J Virol (1993) 1.34

Specific interactions of HeLa cell proteins with proposed translation domains of the poliovirus 5' noncoding region. J Virol (1992) 1.34

Impaired binding of standard initiation factors mediates poliovirus translation attenuation. J Virol (2003) 1.33

Replication of poliovirus in Xenopus oocytes requires two human factors. EMBO J (1996) 1.31

A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence. J Virol (1992) 1.30

Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein. J Virol (1997) 1.29

Host cell proteins binding to domain IV of the 5' noncoding region of poliovirus RNA. J Virol (1995) 1.26

Minimum internal ribosome entry site required for poliovirus infectivity. J Virol (1993) 1.25

Cis-active RNA elements (CREs) and picornavirus RNA replication. Virus Res (2008) 1.25

Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation. J Virol (1997) 1.21

5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA. J Virol (2005) 1.19

Genetic variation in vivo and proposed functional domains of the 5' noncoding region of poliovirus RNA. J Virol (1992) 1.17

Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence. J Virol (2005) 1.15

Gross rearrangements within the 5'-untranslated region of the picornaviral genomes. Nucleic Acids Res (1990) 1.13

Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence. J Virol (1992) 1.13

Toward a poliovirus-based simian immunodeficiency virus vaccine: correlation between genetic stability and immunogenicity. J Virol (1997) 1.08

Yeast cells are incapable of translating RNAs containing the poliovirus 5' untranslated region: evidence for a translational inhibitor. J Virol (1992) 1.06

Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity. J Virol (1996) 1.05

Efficient analysis of nonviable poliovirus capsid mutants. J Virol (1993) 1.04

5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart. Virology (2008) 1.02

Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity. Virology (2009) 1.01

The hepatitis A virus polyprotein expressed by a recombinant vaccinia virus undergoes proteolytic processing and assembly into viruslike particles. J Virol (1991) 1.00

Interaction of translation initiation factor eIF4B with the poliovirus internal ribosome entry site. J Virol (2002) 1.00

Replication of hepatitis A viruses with chimeric 5' nontranslated regions. J Virol (1996) 0.99

trans complementation of cap-independent translation directed by poliovirus 5' noncoding region deletion mutants: evidence for RNA-RNA interactions. J Virol (1993) 0.99

Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G. J Virol (2008) 0.97

Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication. Virology (2006) 0.94

Replication of poliovirus RNA with complete internal ribosome entry site deletions. J Virol (2004) 0.92

Temperature-sensitive hepatitis A virus mutants with deletions downstream of the first pyrimidine-rich tract of the 5' nontranslated RNA are impaired in RNA synthesis. J Virol (1995) 0.90

A new internal ribosomal entry site 5' boundary is required for poliovirus translation initiation in a mouse system. J Virol (1998) 0.87

Sequence analysis of the downstream 5' nontranslated region of seven echoviruses with different neurovirulence phenotypes. J Virol (1995) 0.87

Poly(rC) binding proteins and the 5' cloverleaf of uncapped poliovirus mRNA function during de novo assembly of polysomes. J Virol (2008) 0.86

An internal ribosome entry site directs translation of the 3'-gene from Pelargonium flower break virus genomic RNA: implications for infectivity. PLoS One (2011) 0.85

Cell proteins bind to a linear polypyrimidine-rich sequence within the 5'-untranslated region of rhinovirus 14 RNA. J Virol (1995) 0.84

A three-nucleotide insertion in the H stem-loop of the 5' untranslated region of Theiler's virus attenuates neurovirulence. J Virol (1993) 0.83

A host-specific, temperature-sensitive translation defect determines the attenuation phenotype of a human rhinovirus/poliovirus chimera, PV1(RIPO). J Virol (2011) 0.83

Independent evolution of tetraloop in enterovirus oriL replicative element and its putative binding partners in virus protein 3C. PeerJ (2017) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54

Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56

Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature (1981) 16.61

Cloned poliovirus complementary DNA is infectious in mammalian cells. Science (1981) 12.50

Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc Natl Acad Sci U S A (1981) 12.00

High efficiency polyoma DNA transfection of chloroquine treated cells. Nucleic Acids Res (1983) 9.94

Complete nucleotide sequences of all three poliovirus serotype genomes. Implication for genetic relationship, gene function and antigenic determinants. J Mol Biol (1984) 8.06

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. J Biol Chem (1982) 7.82

The 5' end of poliovirus mRNA is not capped with m7G(5')ppp(5')Np. Proc Natl Acad Sci U S A (1976) 7.26

Defective viral particles and viral disease processes. Nature (1970) 7.24

5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proc Natl Acad Sci U S A (1976) 6.78

Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature (1985) 6.01

Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region. Mol Cell Biol (1988) 4.97

Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94

Regulation of translation by poliovirus. Adv Virus Res (1987) 4.08

Construction of viable deletion and insertion mutants of the Sabin strain of type 1 poliovirus: function of the 5' noncoding sequence in viral replication. J Virol (1987) 3.79

Genetic complementation among poliovirus mutants derived from an infectious cDNA clone. J Virol (1986) 3.65

Identification of the initiation site of poliovirus polyprotein synthesis. J Virol (1982) 3.62

The genomes of attenuated and virulent poliovirus strains differ in their in vitro translation efficiencies. Virology (1985) 3.29

Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection. J Virol (1987) 3.07

Poliovirus temperature-sensitive mutant containing a single nucleotide deletion in the 5'-noncoding region of the viral RNA. Virology (1986) 2.95

A chimeric plasmid from cDNA clones of poliovirus and coxsackievirus produces a recombinant virus that is temperature-sensitive. Proc Natl Acad Sci U S A (1986) 1.90

Articles by these authors

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46

Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A (1993) 22.33

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54

Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08

RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature (1970) 19.38

An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23

I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (1988) 16.40

Immunoglobulin gene transcription is activated by downstream sequence elements. Cell (1983) 15.53

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell (1986) 15.30

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (1986) 14.34

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science (1996) 13.87

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J Virol (1981) 13.11

NF-kappa B: ten years after. Cell (1996) 12.80

Cloned poliovirus complementary DNA is infectious in mammalian cells. Science (1981) 12.50

Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc Natl Acad Sci U S A (1981) 12.00

Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion. Proc Natl Acad Sci U S A (1970) 11.83

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor. Cell (1988) 11.62

NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell (1989) 11.19

The "initiator" as a transcription control element. Cell (1989) 11.13

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science (1990) 10.59

Polypeptide cleavages in the formation of poliovirus proteins. Proc Natl Acad Sci U S A (1968) 10.43

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36

The V(D)J recombination activating gene, RAG-1. Cell (1989) 9.79

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell (1981) 9.54

Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J Virol (1989) 9.37

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature (1990) 9.31

Further evidence on the formation of poliovirus proteins. J Mol Biol (1970) 9.29

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24

A detailed model of reverse transcription and tests of crucial aspects. Cell (1979) 8.93

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (1986) 8.64

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53

Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell (1985) 8.16

Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus. Proc Natl Acad Sci U S A (1977) 8.12

Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05

Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science (1987) 7.63

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell (1995) 7.55

ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28

Defective viral particles and viral disease processes. Nature (1970) 7.24

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature (1998) 6.94

A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA. Cell (1990) 6.85

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity (1999) 6.80

5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proc Natl Acad Sci U S A (1976) 6.78

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature (1980) 6.76

Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration. Proc Natl Acad Sci U S A (1980) 6.73

Gene conversion: some implications for immunoglobulin genes. Cell (1981) 6.70

Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63

Morphogenesis of poliovirus. I. Association of the viral RNA with coat protein. J Mol Biol (1968) 6.58

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol (1990) 6.57

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48

Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci U S A (1978) 6.38

Modular binding domains in signal transduction proteins. Cell (1995) 6.34

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32

Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell (1981) 6.31

Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31

Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA. EMBO J (1993) 6.29

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23

RNA metabolism of murine leukemia virus: detection of virus-specific RNA sequences in infected and uninfected cells and identification of virus-specific messenger RNA. J Mol Biol (1973) 6.19

RNA-directed DNA synthesis and RNA tumor viruses. Adv Virus Res (1972) 6.11

Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell (1979) 6.03

Ribonucleic acid synthesis of vesicular stomatitis virus. 3. Multiple complementary messenger RNA molecules. Virology (1970) 5.99

Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology (1966) 5.85

In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of Moloney murine leukemia virus. Cell (1979) 5.78

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75

Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of ribonucleic acid found in Chinese hamster ovary cells infected with plaque-forming and defective particles. J Virol (1969) 5.73

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73

High frequency of aberrant expression of Moloney murine leukemia virus in clonal infections. Cell (1978) 5.72

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell (1980) 5.68

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev (1989) 5.61

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59

Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses. Proc Natl Acad Sci U S A (1971) 5.55

The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell (1990) 5.39

The mechanism of RNA recombination in poliovirus. Cell (1986) 5.35

Translation of MuLV and MSV RNAs in nuclease-treated reticulocyte extracts: enhancement of the gag-pol polypeptide with yeast suppressor tRNA. Cell (1978) 5.31

RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci U S A (2001) 5.21

Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs. J Virol (1985) 5.21

A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med (1976) 5.13

Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94

An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell (1991) 4.80

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. Proc Natl Acad Sci U S A (1990) 4.79

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med (1996) 4.79

Ordered transcription of RNA tumor virus genomes. J Mol Biol (1976) 4.78

Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency. Cell (1990) 4.78

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc Natl Acad Sci U S A (1991) 4.66

Inhibition of translation by poliovirus: inactivation of a specific initiation factor. Proc Natl Acad Sci U S A (1978) 4.59

Switch from translation to RNA replication in a positive-stranded RNA virus. Genes Dev (1998) 4.59

Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature (1990) 4.59

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science (1992) 4.57

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46

Tumor viruses: 1974. Cold Spring Harb Symp Quant Biol (1975) 4.44

Retracted Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity (1999) 4.42

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42

HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell (1989) 4.40

Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell (1997) 4.39

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev (1995) 4.38

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J (1995) 4.36