Published in Protein Sci on May 15, 2017
Pathogenesis of group A streptococcal infections. Clin Microbiol Rev (2000) 15.35
Antibiotic resistance-the need for global solutions. Lancet Infect Dis (2013) 15.01
The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis (2008) 9.57
Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol Microbiol (2002) 6.03
Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science (1999) 5.98
Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev (2006) 4.88
Conservation of a hexapeptide sequence in the anchor region of surface proteins from gram-positive cocci. Mol Microbiol (1990) 4.50
A pneumococcal pilus influences virulence and host inflammatory responses. Proc Natl Acad Sci U S A (2006) 4.40
Anti-virulence strategies to combat bacteria-mediated disease. Nat Rev Drug Discov (2010) 4.23
Pili in gram-positive pathogens. Nat Rev Microbiol (2006) 4.21
Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science (2007) 4.10
Genome analysis reveals pili in Group B Streptococcus. Science (2005) 3.85
Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome. Microbiol Mol Biol Rev (2000) 3.81
Assembly of pili on the surface of Corynebacterium diphtheriae. Mol Microbiol (2003) 3.79
Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens. Proc Natl Acad Sci U S A (2005) 3.59
Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in gram-positive bacteria. Mol Microbiol (1994) 3.57
Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus. Mol Microbiol (2001) 3.39
Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest (2006) 3.33
An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc Natl Acad Sci U S A (2002) 3.23
Infections caused by Gram-positive bacteria: a review of the global challenge. J Infect (2009) 3.06
Assembly and role of pili in group B streptococci. Mol Microbiol (2006) 2.92
Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. Trends Microbiol (2008) 2.83
Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol Microbiol (2004) 2.80
Assembly of pili in Gram-positive bacteria. Trends Microbiol (2004) 2.76
An embarrassment of sortases - a richness of substrates? Trends Microbiol (2001) 2.74
Pili in Gram-negative and Gram-positive bacteria - structure, assembly and their role in disease. Cell Mol Life Sci (2009) 2.69
Protein sorting to the cell wall envelope of Gram-positive bacteria. Biochim Biophys Acta (2004) 2.42
Pili with strong attachments: Gram-positive bacteria do it differently. Mol Microbiol (2006) 2.36
Identification of novel genomic islands coding for antigenic pilus-like structures in Streptococcus agalactiae. Mol Microbiol (2006) 2.31
Sorting sortases: a nomenclature proposal for the various sortases of Gram-positive bacteria. Res Microbiol (2005) 2.20
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet. Infect Immun (2006) 2.18
Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol (2006) 2.16
Protein secretion and the pathogenesis of bacterial infections. Genes Dev (2001) 2.13
Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae. Structure (2010) 2.06
A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria. Infect Immun (2004) 2.04
Assembly of distinct pilus structures on the surface of Corynebacterium diphtheriae. J Bacteriol (2006) 1.98
Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae. Mol Microbiol (2007) 1.82
Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes. Infect Immun (2002) 1.80
The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A (2009) 1.79
Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds. Nat Rev Microbiol (2011) 1.79
Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells. J Bacteriol (2006) 1.78
Genome-wide detection and analysis of cell wall-bound proteins with LPxTG-like sorting motifs. J Bacteriol (2005) 1.75
The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria. Proc Natl Acad Sci U S A (2008) 1.75
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge. Infect Immun (2006) 1.74
Presence of pili in species of human and animal parasites and pathogens of the genuscorynebacterium. Infect Immun (1976) 1.74
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol (2008) 1.72
Sortase-catalyzed assembly of distinct heteromeric fimbriae in Actinomyces naeslundii. J Bacteriol (2007) 1.71
Assembly of pili on the surface of Bacillus cereus vegetative cells. Mol Microbiol (2007) 1.67
Sortase as a target of anti-infective therapy. Pharmacol Rev (2008) 1.64
An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion. Structure (2007) 1.64
Epidemiology of severe sepsis around the world. Endocr Metab Immune Disord Drug Targets (2006) 1.63
Type III pilus of corynebacteria: Pilus length is determined by the level of its major pilin subunit. J Bacteriol (2006) 1.63
Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. J Biol Chem (2009) 1.52
Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infect Immun (2008) 1.51
Identification of a gene involved in assembly of Actinomyces naeslundii T14V type 2 fimbriae. Infect Immun (1998) 1.51
Targeting proteins to the cell wall of sporulating Bacillus anthracis. Mol Microbiol (2006) 1.49
Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes. J Biol Chem (2009) 1.45
A novel sortase, SrtC2, from Streptococcus pyogenes anchors a surface protein containing a QVPTGV motif to the cell wall. J Bacteriol (2004) 1.38
Streptococcus pneumoniae--a review of carriage, infection, serotype replacement and vaccination. Paediatr Respir Rev (2012) 1.37
Sortase enzymes in Gram-positive bacteria. Mol Microbiol (2011) 1.37
Role of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in modulating bacterium-host interactions. Proc Natl Acad Sci U S A (2013) 1.36
Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC. J Biol Chem (2005) 1.34
Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA. Biochemistry (2004) 1.34
A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J (2008) 1.31
Molecular architecture of Streptococcus pneumoniae TIGR4 pili. EMBO J (2009) 1.29
Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49. Infect Immun (2008) 1.28
Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus. J Bacteriol (2008) 1.25
A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction. J Biol Chem (2010) 1.25
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22
Structure and assembly of Gram-positive bacterial pili: unique covalent polymers. Curr Opin Struct Biol (2012) 1.21
Staphylococcus aureus Sortase A transpeptidase. Calcium promotes sorting signal binding by altering the mobility and structure of an active site loop. J Biol Chem (2005) 1.21
Linkage of T3 and Cpa pilins in the Streptococcus pyogenes M3 pilus. Mol Microbiol (2009) 1.19
Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes. J Infect Dis (2008) 1.18
Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae. Structure (2008) 1.17
SipA is required for pilus formation in Streptococcus pyogenes serotype M3. J Bacteriol (2007) 1.16
Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring. J Biol Chem (2010) 1.16
Type IV pili in Gram-positive bacteria. Microbiol Mol Biol Rev (2013) 1.14
Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus. PLoS One (2010) 1.11
Genetic organization and preferential distribution of putative pilus gene clusters in Streptococcus suis. Vet Microbiol (2009) 1.10
Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections. Proc Natl Acad Sci U S A (2011) 1.09
Anchoring of surface proteins to the cell wall of Staphylococcus aureus. A conserved arginine residue is required for efficient catalysis of sortase A. J Biol Chem (2004) 1.09
Structural biology of Gram-positive bacterial adhesins. Protein Sci (2011) 1.07
Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus. PLoS One (2010) 1.06
A model for group B Streptococcus pilus type 1: the structure of a 35-kDa C-terminal fragment of the major pilin GBS80. J Mol Biol (2011) 1.06
Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05
Acyl enzyme intermediates in sortase-catalyzed pilus morphogenesis in gram-positive bacteria. J Bacteriol (2009) 1.04
Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA. J Biol Chem (2007) 1.03
Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci. Int J Med Microbiol (2010) 1.00
Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin. Proc Natl Acad Sci U S A (2013) 0.98
Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS One (2011) 0.98
Sortase activity is controlled by a flexible lid in the pilus biogenesis mechanism of gram-positive pathogens. Biochemistry (2009) 0.98
Environmental acidification drives S. pyogenes pilus expression and microcolony formation on epithelial cells in a FCT-dependent manner. PLoS One (2010) 0.95
Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. J Biol Chem (2013) 0.95
Enhancement of sortase A-mediated protein ligation by inducing a β-hairpin structure around the ligation site. Chem Commun (Camb) (2011) 0.95
Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili. PLoS One (2011) 0.93
Cell surface display of minor pilin adhesins in the form of a simple heterodimeric assembly in Corynebacterium diphtheriae. Mol Microbiol (2011) 0.93
Mutations in the gene encoding the ancillary pilin subunit of the Streptococcus suis srtF cluster result in pili formed by the major subunit only. PLoS One (2010) 0.91
Sortase A: an ideal target for anti-virulence drug development. Microb Pathog (2014) 0.91
The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo. Infect Immun (2010) 0.90
The full-length Streptococcus pneumoniae major pilin RrgB crystallizes in a fibre-like structure, which presents the D1 isopeptide bond and provides details on the mechanism of pilus polymerization. Biochem J (2012) 0.90