Evolving Approaches in the Identification of Allograft-reactive T and B Cells in Mice and Humans.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28604446)

Published in Transplantation on June 08, 2017

Authors

James S Young1, Christine McIntosh, Maria-Luisa Alegre, Anita S Chong

Author Affiliations

1: 1 Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL. 2 Section of Rheumatology, Department of Medicine, The University of Chicago, Chicago, IL.

Articles cited by this

(truncated to the top 100)

Maintenance of serological memory by polyclonal activation of human memory B cells. Science (2002) 8.75

The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol (2008) 7.23

Cutting edge: long-term B cell memory in humans after smallpox vaccination. J Immunol (2003) 5.51

Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant (2011) 4.06

Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients. Sci Transl Med (2015) 3.71

Different B cell populations mediate early and late memory during an endogenous immune response. Science (2011) 3.63

Multiple layers of B cell memory with different effector functions. Nat Immunol (2009) 3.33

Generation of T-cell receptor retrogenic mice. Nat Protoc (2006) 3.05

Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J Immunol (2001) 2.93

Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol (1999) 2.79

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat Immunol (2000) 2.37

Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods (2003) 2.28

Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathway. Nat Immunol (2002) 2.25

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy. Nat Med (2011) 2.14

Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J Immunol (1999) 2.13

CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol (2004) 1.99

Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members. Blood (2009) 1.94

Human allograft acceptance is associated with immune regulation. J Clin Invest (2000) 1.94

A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J Exp Med (2012) 1.86

Clonal dissection of the human memory B-cell repertoire following infection and vaccination. Eur J Immunol (2009) 1.74

Assessing Antibody Strength: Comparison of MFI, C1q, and Titer Information. Am J Transplant (2015) 1.72

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. J Exp Med (2007) 1.68

Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection. J Immunol (2002) 1.68

Cryptic B cell response to renal transplantation. Am J Transplant (2013) 1.57

Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nat Med (2002) 1.54

The Synergistic Effect of Class II HLA Epitope-Mismatch and Nonadherence on Acute Rejection and Graft Survival. Am J Transplant (2015) 1.53

Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells. Am J Transplant (2013) 1.52

Understanding and making use of human memory B cells. Immunol Rev (2006) 1.46

Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production. Am J Transplant (2008) 1.37

Contribution of naïve and memory T-cell populations to the human alloimmune response. Am J Transplant (2009) 1.34

Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance. J Exp Med (2004) 1.34

Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J Exp Med (2002) 1.25

Human leukocyte antigen gene polymorphism and the histocompatibility laboratory. J Mol Diagn (2001) 1.25

Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant (2003) 1.21

Antibody-mediated rejection, T cell-mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies. Kidney Int (2013) 1.21

Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity. J Immunol (2008) 1.17

A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity (2001) 1.14

Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer. J Immunol (2004) 1.13

Cognate antigen directs CD8+ T cell migration to vascularized transplants. J Clin Invest (2013) 1.09

Trans vivo analysis of human delayed-type hypersensitivity reactivity. Hum Immunol (1999) 1.09

IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury. J Am Soc Nephrol (2015) 1.07

T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection. Transplantation (2002) 1.06

A new T-cell receptor transgenic model of the CD4+ direct pathway: level of priming determines acute versus chronic rejection. Transplantation (2008) 1.03

HLA antibody identification with single antigen beads compared to conventional methods. Hum Immunol (2005) 1.02

HLA-specific B cells: I. A method for their detection, quantification, and isolation using HLA tetramers. Transplantation (2007) 0.99

HLA-specific B cells: II. Application to transplantation. Transplantation (2007) 0.97

An essential contribution by IFN-gamma to CD8+ T cell-mediated rejection of pancreatic islet allografts. J Immunol (2000) 0.96

Surface markers of lymphocyte activation and markers of cell proliferation. Clin Chim Acta (2011) 0.96

Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients. J Am Soc Nephrol (2014) 0.96

Clinical cytometry and progress in HLA antibody detection. Methods Cell Biol (2011) 0.95

The third dimension of ELISPOTs: quantifying antibody secretion from individual plasma cells. J Immunol Methods (2009) 0.94

Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients. J Immunol (2015) 0.93

Indirect minor histocompatibility antigen presentation by allograft recipient cells in the draining lymph node leads to the activation and clonal expansion of CD4+ T cells that cause obliterative airways disease. J Immunol (2004) 0.93

Two novel assays of alloantibody-secreting cells demonstrating resistance to desensitization with IVIG and rATG. Am J Transplant (2008) 0.93

Memory alloreactive B cells and alloantibodies prevent anti-CD154-mediated allograft acceptance. J Immunol (2009) 0.92

HLA antibody detection with solid phase assays: great expectations or expectations too great? Am J Transplant (2014) 0.92

Memory T cells migrate to and reject vascularized cardiac allografts independent of the chemokine receptor CXCR3. Transplantation (2011) 0.91

Donor T cell activation initiates small bowel allograft rejection through an IFN-gamma-inducible protein-10-dependent mechanism. J Immunol (2002) 0.91

Costimulatory pathways in transplantation. Semin Immunol (2011) 0.90

The spleen is the major source of antidonor antibody-secreting cells in murine heart allograft recipients. Am J Transplant (2012) 0.89

Rates and Determinants of Progression to Graft Failure in Kidney Allograft Recipients With De Novo Donor-Specific Antibody. Am J Transplant (2015) 0.88

Detection of alloreactive T cells by flow cytometry: a new test compared with limiting dilution assay. Transplantation (2002) 0.86

A NOVel ELISPOT assay to quantify HLA-specific B cells in HLA-immunized individuals. Am J Transplant (2012) 0.85

Allograft outcomes in outbred mice. Am J Transplant (2013) 0.85

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Proc Natl Acad Sci U S A (2007) 0.85

TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol (2014) 0.84

Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer. Proc Natl Acad Sci U S A (2016) 0.84

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. Kidney Int (2014) 0.84

Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig. Am J Transplant (2013) 0.84

H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J Exp Med (2000) 0.84

Defining the alloreactive T cell repertoire using high-throughput sequencing of mixed lymphocyte reaction culture. PLoS One (2014) 0.84

Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol (2006) 0.84

Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells. Clin Exp Immunol (2013) 0.84

General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice. J Immunol (2015) 0.83

Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation. Transplantation (2016) 0.83

Acquisition of humoral transplantation tolerance upon de novo emergence of B lymphocytes. J Immunol (2010) 0.83

Fluorescence-activated cell sorting and cloning of bona fide CD8+ CTL with reversible MHC-peptide and antibody Fab' conjugates. J Immunol (2006) 0.83

Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol (2002) 0.83

Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells. J Immunol (2012) 0.83

T cell activation: in vivo veritas. Immunol Cell Biol (2004) 0.82

Peripheral blood B cells producing donor-specific HLA antibodies in vitro. Hum Immunol (2008) 0.82

Memory B cells in transplantation. Transplantation (2015) 0.82

MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses. J Immunol (2002) 0.82

Allospecific CD4(+) T cells retain effector function and are actively regulated by Treg cells in the context of transplantation tolerance. Eur J Immunol (2015) 0.82

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes. Nat Biotechnol (2016) 0.81

Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment. Am J Transplant (2012) 0.81

Measurement of immunoglobulin synthesis using the ELISPOT assay. Curr Protoc Immunol (2001) 0.80

Preformed circulating HLA-specific memory B cells predict high risk of humoral rejection in kidney transplantation. Kidney Int (2015) 0.80

Interferon Gamma ELISPOT Testing as a Risk-Stratifying Biomarker for Kidney Transplant Injury: Results From the CTOT-01 Multicenter Study. Am J Transplant (2015) 0.79

IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice. Proc Natl Acad Sci U S A (2015) 0.79

Non-HLA antibodies against endothelial targets bridging allo- and autoimmunity. Kidney Int (2016) 0.79

Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells. Am J Transplant (2007) 0.79

Value of Donor-Specific Anti-HLA Antibody Monitoring and Characterization for Risk Stratification of Kidney Allograft Loss. J Am Soc Nephrol (2016) 0.79

Quantification of HLA class II-specific memory B cells in HLA-sensitized individuals. Hum Immunol (2015) 0.78

Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It. Cell Rep (2016) 0.78

Role of non-H-2 antigens in the cytotoxic T cell response to allogeneic H-2. Eur J Immunol (1982) 0.78

Characterization of antigen-specific B cells using nominal antigen-coated flow-beads. PLoS One (2013) 0.77

Pharmacodynamic monitoring of the conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in stable kidney-allograft recipients. Int Immunopharmacol (2008) 0.77

Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice. J Immunol (1995) 0.77

Adoptive transfer of tracer alloreactive CD4(+) TCR-transgenic T cells alters the endogenous immune response to an allograft. Am J Transplant (2016) 0.76

Articles by these authors

Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol (2003) 5.47

GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev (2003) 2.97

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med (2006) 2.35

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest (2004) 1.71

Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice. PLoS One (2010) 1.58

Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity (2013) 1.52

CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J Immunol (2009) 1.40

Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood (2005) 1.35

T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol (2008) 1.30

Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J Rheumatol (2002) 1.28

TLR signals promote IL-6/IL-17-dependent transplant rejection. J Immunol (2009) 1.26

Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol (2008) 1.25

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Diabetes (2006) 1.19

Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration. Mol Cell Biol (2004) 1.18

High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner. J Immunol (2011) 1.15

Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol (2004) 1.13

Modulating adaptive immune responses to peptide self-assemblies. ACS Nano (2012) 1.09

Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS One (2010) 1.09

Establishment of a global virtual laboratory for transplantation: a symposium report. Transplantation (2015) 1.07

Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A (2009) 1.06

The balance of immune responses: costimulation verse coinhibition. J Mol Med (Berl) (2005) 1.06

Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun (2014) 1.05

Secondary lymphoid organs are important but not absolutely required for allograft responses. Am J Transplant (2003) 1.04

Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells. Proc Natl Acad Sci U S A (2004) 1.03

The impact of infection and tissue damage in solid-organ transplantation. Nat Rev Immunol (2012) 1.03

A mouse model for studying intrahepatic islet transplantation. Transplantation (2004) 1.01

Local inflammation exacerbates the severity of Staphylococcus aureus skin infection. PLoS One (2013) 0.99

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope. Biomaterials (2012) 0.99

TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. J Immunol (2002) 0.98

Cutting Edge: NK cells mediate IgG1-dependent hyperacute rejection of xenografts. J Immunol (2004) 0.98

Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells. Proc Natl Acad Sci U S A (2009) 0.97

CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol (2003) 0.95

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. Biomaterials (2013) 0.94

Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Transplantation (2010) 0.94

Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming. J Immunol (2010) 0.93

Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am J Transplant (2003) 0.93

Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice. J Immunol (2004) 0.92

Memory alloreactive B cells and alloantibodies prevent anti-CD154-mediated allograft acceptance. J Immunol (2009) 0.92

Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL. J Immunol (2005) 0.92

Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. Transplantation (2005) 0.91

A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. Adv Healthc Mater (2013) 0.90

Role of CD4+ and CD8+ T cells in the rejection of concordant pancreas xenografts. Transplantation (2002) 0.90

The composition of the microbiota modulates allograft rejection. J Clin Invest (2016) 0.88

Hyperacute rejection by anti-Gal IgG1, IgG2a, and IgG2b is dependent on complement and Fc-gamma receptors. J Immunol (2008) 0.87

Transplantation tolerance and its outcome during infections and inflammation. Immunol Rev (2014) 0.86

Toll-like receptor signaling in transplantation. Curr Opin Organ Transplant (2008) 0.86

T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation. Proc Natl Acad Sci U S A (2012) 0.85

Allograft tolerance induced by intact active bone co-transplantation and anti-CD40L monoclonal antibody therapy. Transplantation (2002) 0.85

Bacterial infections, alloimmunity, and transplantation tolerance. Transplant Rev (Orlando) (2011) 0.85

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Proc Natl Acad Sci U S A (2007) 0.85

CTLA-4 engagement regulates NF-kappaB activation in vivo. Eur J Immunol (2002) 0.84

Role of bacterial infections in allograft rejection. Expert Rev Clin Immunol (2008) 0.84

Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation. Transplantation (2016) 0.83

Role of T cell-nuclear factor κB in transplantation. Transplant Rev (Orlando) (2011) 0.83

Long-term control of alloreactive B cell responses by the suppression of T cell help. J Immunol (2008) 0.83

IFN-gamma production is specifically regulated by IL-10 in mice made tolerant with anti-CD40 ligand antibody and intact active bone. J Immunol (2003) 0.82

Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J Immunol (2002) 0.82

Nephrogenic systemic fibrosis associated with stromal and vascular calcification, report of two cases. J Cutan Pathol (2008) 0.81

Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin. PLoS One (2013) 0.81

Microbes and allogeneic transplantation. Transplantation (2014) 0.81

Acute xenograft rejection mediated by antibodies produced independently of TH1/TH2 cytokine profiles. Am J Transplant (2002) 0.80

Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance. Transplantation (2004) 0.80

Skin graft survival in genetically identical cloned pigs. Cloning Stem Cells (2003) 0.80

Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs. Adv Healthc Mater (2014) 0.80

Mechanisms and consequences of injury and repair in older organ transplants. Transplantation (2014) 0.80

The influence of the microbiota on the immune response to transplantation. Curr Opin Organ Transplant (2015) 0.79

Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling. Transpl Int (2009) 0.79

Role of T-cell-specific nuclear factor κB in islet allograft rejection. Transplantation (2012) 0.79

Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients. Transplantation (2014) 0.78

Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection. Transpl Int (2012) 0.78

Lessons and limits of mouse models. Cold Spring Harb Perspect Med (2013) 0.78

High-Fat Diet-Induced Obesity Enhances Allograft Rejection. Transplantation (2016) 0.78

Experimental models of B cell tolerance in transplantation. Semin Immunol (2011) 0.77

Overexpression of program death-1 in T cells has mild impact on allograft survival. Transpl Int (2008) 0.77

CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight (2017) 0.76

Transplantation tolerance after allograft rejection. Curr Opin Organ Transplant (2016) 0.75

Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway. Am J Transplant (2012) 0.75

Dendritic Cell Identification for Dummies. Am J Transplant (2017) 0.75

The Bugs That Keep Us Safe. Am J Transplant (2017) 0.75

The Multiple Molecular Paths of Antibody Suppression by TFR Cells. Am J Transplant (2017) 0.75

Direct killing of xenograft cells by CD8+ T cells of discordant xenograft recipients. Transplantation (2002) 0.75

Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression. Am J Transplant (2016) 0.75

The Unbearable Lightness of Breathing. Am J Transplant (2017) 0.75

B cells assist allograft rejection in the deficiency of protein kinase c-theta. Transpl Int (2013) 0.75

Timing Is Everything. Am J Transplant (2017) 0.75

Making Therapeutic Antibodies in Vitro. Am J Transplant (2017) 0.75

Select Effects of IL-13 in Driving Tissue Repair and Fibrosis. Am J Transplant (2016) 0.75

Predicting TCR specificity? Am J Transplant (2017) 0.75

Immune-Electrical Connection. Am J Transplant (2017) 0.75

The Tpm Subset of the CD8(+) T Cell Memory Family. Am J Transplant (2017) 0.75