Published in Front Mol Neurosci on May 29, 2017
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev (2004) 6.98
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev (2008) 6.57
Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci (2005) 5.93
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell (2006) 5.58
Cytochrome C-mediated apoptosis. Annu Rev Biochem (2004) 5.38
Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci (2006) 4.87
Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem (1990) 4.03
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Cell (2011) 4.00
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med (2010) 3.48
Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci U S A (1994) 3.46
Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev (2008) 3.05
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J Biol Chem (2003) 2.81
The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. Biochem Pharmacol (2012) 2.36
Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann N Y Acad Sci (2008) 2.27
Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol (1996) 2.22
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc Res (2004) 1.80
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem (2009) 1.78
Complex I and Parkinson's disease. IUBMB Life (2002) 1.66
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem (2011) 1.57
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease. Cell Mol Life Sci (2011) 1.42
Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener (2011) 1.23
The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol (2010) 1.04
PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond. Prog Neurobiol (2011) 1.00
The role of PGC-1α in the pathogenesis of neurodegenerative disorders. Curr Drug Targets (2010) 0.98
Cytochrome c causes pore formation in cardiolipin-containing membranes. Proc Natl Acad Sci U S A (2013) 0.97
Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP(+)-induced mitochondrial dysfunctions in neuronal cells. Biochim Biophys Acta (2011) 0.96
Origin of the conformational heterogeneity of cardiolipin-bound cytochrome C. J Am Chem Soc (2012) 0.95
Effect of resveratrol on mitochondrial function: implications in parkin-associated familiar Parkinson's disease. Biochim Biophys Acta (2014) 0.95
Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration. Transl Neurodegener (2013) 0.92
Functional analysis of the rat cytochrome c oxidase subunit 6A1 promoter in primary neurons. Gene (2004) 0.92
Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c. Proc Natl Acad Sci U S A (2012) 0.90
A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha). Biochem Pharmacol (2010) 0.84
Quantitative immuno-electron microscopic analysis of nuclear respiratory factor 2 alpha and beta subunits: Normal distribution and activity-dependent regulation in mammalian visual cortex. Vis Neurosci (2005) 0.83
Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons. Mol Neurobiol (2015) 0.82
Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. J Neuropathol Exp Neurol (2011) 0.77
Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons. Neuropharmacology (2015) 0.77
Exercise, PGC-1alpha, and metabolic adaptation in skeletal muscle. Appl Physiol Nutr Metab (2009) 0.76