Published in Front Physiol on June 13, 2017
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
Network biology: understanding the cell's functional organization. Nat Rev Genet (2004) 36.62
TOR signaling in growth and metabolism. Cell (2006) 35.29
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
mTOR signaling in growth control and disease. Cell (2012) 29.21
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 17.19
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet (1997) 15.38
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32
Metabolic stability and epigenesis in randomly constructed genetic nets. J Theor Biol (1969) 13.14
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell (2002) 11.59
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell (2002) 11.50
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
TOR, a central controller of cell growth. Cell (2000) 10.41
Computational systems biology. Nature (2002) 10.33
Modeling and simulation of genetic regulatory systems: a literature review. J Comput Biol (2002) 9.97
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol (2003) 8.25
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol (2004) 7.59
Perturbations of the AKT signaling pathway in human cancer. Oncogene (2005) 6.64
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res (1997) 5.92
PTEN: one gene, many syndromes. Hum Mutat (2003) 5.79
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A (2004) 5.16
Diabetes and cancer. Endocr Relat Cancer (2009) 5.04
The logical analysis of continuous, non-linear biochemical control networks. J Theor Biol (1973) 5.02
Dynamical behaviour of biological regulatory networks--I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state. Bull Math Biol (1995) 4.59
The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene (2008) 4.39
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol (2003) 4.01
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem (2003) 3.83
Circuit simulation of genetic networks. Science (1995) 3.71
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology (2004) 3.50
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2007) 3.32
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol (2009) 3.32
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene (2006) 3.18
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08
Common corruption of the mTOR signaling network in human tumors. Oncogene (2008) 2.60
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol (2009) 2.57
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell (2007) 2.43
Molecular organization of target of rapamycin complex 2. J Biol Chem (2005) 2.15
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell (2010) 2.11
Qualitative simulation of genetic regulatory networks using piecewise-linear models. Bull Math Biol (2004) 1.65
Rictor is a novel target of p70 S6 kinase-1. Oncogene (2009) 1.52
Application of formal methods to biological regulatory networks: extending Thomas' asynchronous logical approach with temporal logic. J Theor Biol (2004) 1.43
PTEN function: the long and the short of it. Trends Biochem Sci (2014) 1.29
Dynamical behaviour of biological regulatory networks--II. Immunity control in bacteriophage lambda. Bull Math Biol (1995) 1.28
Logical analysis of systems comprising feedback loops. J Theor Biol (1978) 1.09
SnapShot: PTEN signaling pathways. Cell (2008) 0.97
Modeling the normal and neoplastic cell cycle with "realistic Boolean genetic networks": their application for understanding carcinogenesis and assessing therapeutic strategies. Pac Symp Biocomput (1998) 0.95
Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS. Mol Syst Biol (2012) 0.88
Formal modeling and analysis of the MAL-associated biological regulatory network: insight into cerebral malaria. PLoS One (2012) 0.85
A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin. FEBS J (2012) 0.84
Formal modelling of toll like receptor 4 and JAK/STAT signalling pathways: insight into the roles of SOCS-1, interferon-β and proinflammatory cytokines in sepsis. PLoS One (2014) 0.82
Analysing formal models of genetic regulatory networks with delays. Int J Bioinform Res Appl (2008) 0.78
Invariance kernel of biological regulatory networks. Int J Data Min Bioinform (2010) 0.76
On the modelling and analysis of the regulatory network of dengue virus pathogenesis and clearance. Comput Biol Chem (2014) 0.76
Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. PeerJ (2016) 0.75
Unraveling the regulation of mTORC2 using logical modeling. Cell Commun Signal (2017) 0.75