Published in Cell on December 01, 1985
In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes. Proc Natl Acad Sci U S A (1993) 4.82
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol (1993) 3.85
Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation. Nucleic Acids Res (2009) 3.44
Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD. Genes Dev (2001) 2.72
Sequences capable of restoring poly(A) site function define two distinct downstream elements. EMBO J (1986) 2.69
The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro. Mol Cell Biol (1986) 2.62
Assembly of a processive messenger RNA polyadenylation complex. EMBO J (1993) 2.58
A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. Proc Natl Acad Sci U S A (1992) 2.53
A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal. Mol Cell Biol (1990) 2.43
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J (2000) 2.37
Gamma-monomethyl phosphate: a cap structure in spliceosomal U6 small nuclear RNA. Proc Natl Acad Sci U S A (1989) 2.34
Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit. Mol Cell Biol (1989) 2.33
Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding. EMBO J (1988) 2.32
Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proc Natl Acad Sci U S A (1997) 2.31
The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. Mol Cell Biol (1988) 2.14
Mutational analysis of a yeast transcriptional terminator. Proc Natl Acad Sci U S A (1989) 2.12
Both conserved signals on mammalian histone pre-mRNAs associate with small nuclear ribonucleoproteins during 3' end formation in vitro. Mol Cell Biol (1987) 1.98
Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro. Mol Cell Biol (1989) 1.93
Elements upstream of the AAUAAA within the human immunodeficiency virus polyadenylation signal are required for efficient polyadenylation in vitro. Mol Cell Biol (1992) 1.93
Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. J Cell Biol (2000) 1.86
Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol (1987) 1.83
Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA. Mol Cell Biol (1987) 1.79
Expression of a human cytomegalovirus late gene is posttranscriptionally regulated by a 3'-end-processing event occurring exclusively late after infection. Mol Cell Biol (1986) 1.78
Definition of the upstream efficiency element of the simian virus 40 late polyadenylation signal by using in vitro analyses. Mol Cell Biol (1992) 1.72
Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved. EMBO J (1995) 1.71
Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro. Mol Cell Biol (1987) 1.65
Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals. Nucleic Acids Res (1994) 1.64
Different 3' end regions strongly influence the level of gene expression in plant cells. Plant Cell (1989) 1.60
Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol (1999) 1.56
Potentiation of a polyadenylylation site by a downstream protein-DNA interaction. Proc Natl Acad Sci U S A (1990) 1.51
Identification of nuclear cap specific proteins in HeLa cells. Nucleic Acids Res (1987) 1.50
Sedimentation analysis of polyadenylation-specific complexes. Mol Cell Biol (1988) 1.46
An RNA-binding protein specifically interacts with a functionally important domain of the downstream element of the simian virus 40 late polyadenylation signal. Mol Cell Biol (1991) 1.43
His-154 is involved in the linkage of the Saccharomyces cerevisiae L-A double-stranded RNA virus Gag protein to the cap structure of mRNAs and is essential for M1 satellite virus expression. Mol Cell Biol (1994) 1.40
Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals. Mol Cell Biol (1988) 1.38
The contribution of AAUAAA and the upstream element UUUGUA to the efficiency of mRNA 3'-end formation in plants. EMBO J (1994) 1.36
RNA polymerase specificity of mRNA production and enhancer action. Proc Natl Acad Sci U S A (1986) 1.33
Assembly of a polyadenylation-specific 25S ribonucleoprotein complex in vitro. Mol Cell Biol (1988) 1.28
A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell (2013) 1.25
The coat protein of the yeast double-stranded RNA virus L-A attaches covalently to the cap structure of eukaryotic mRNA. Mol Cell Biol (1992) 1.24
Tripartite sequences within and 3' to the sea urchin H2A histone gene display properties associated with a transcriptional termination process. Mol Cell Biol (1986) 1.22
Different 3'-end processing produces two independently regulated mRNAs from a single H1 histone gene. Proc Natl Acad Sci U S A (1989) 1.14
Heterogeneity in mammalian RNA 3' end formation. Exp Cell Res (2010) 1.13
Mutations in poly(A) site downstream elements affect in vitro cleavage activity. Mol Cell Biol (1988) 1.12
Identification of a novel sequence that governs both polyadenylation and alternative splicing in region E3 of adenovirus. Nucleic Acids Res (1987) 1.11
Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites. Mol Cell Biol (1994) 1.09
In vitro cleavage of the simian virus 40 early polyadenylation site adjacent to a required downstream TG sequence. Mol Cell Biol (1986) 1.08
Updating the CTD Story: From Tail to Epic. Genet Res Int (2011) 1.06
Model for alternative RNA processing in human calcitonin gene expression. Nucleic Acids Res (1986) 1.06
Requirement of A-A-U-A-A-A and adjacent downstream sequences for SV40 early polyadenylation. Nucleic Acids Res (1986) 1.04
Role of poly(A) polymerase in the cleavage and polyadenylation of mRNA precursor. Mol Cell Biol (1989) 1.03
Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA. Nucleic Acids Res (1988) 1.02
UV cross-linking of polypeptides associated with 3'-terminal exons. Mol Cell Biol (1990) 0.98
Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein. J Virol (1990) 0.96
Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated. EMBO Rep (2000) 0.94
Discrimination among multiple AATAAA sequences correlates with interspecies conservation of select 3' untranslated nucleotides. Nucleic Acids Res (1986) 0.94
Processing at immunoglobulin polyadenylation sites in lymphoid cell extracts. EMBO J (1988) 0.93
The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo. Nucleic Acids Res (2010) 0.87
Analysis of adenovirus type 2 L1 RNA 3'-end formation in vivo and in vitro. J Virol (1988) 0.87
Deletions in the SV40 late polyadenylation region downstream of the AATAAA mediate similar effects on expression in various mammalian cell lines. Nucleic Acids Res (1988) 0.86
Two Drosophila chorion genes terminate transcription in discrete regions near their poly(A) sites. EMBO J (1986) 0.84
Termination of transcription in an 'in vitro' system is dependent on a polyadenylation sequence. Nucleic Acids Res (1991) 0.79
Cleavage and polyadenylation: Ending the message expands gene regulation. RNA Biol (2017) 0.75
RNA processing of beta-globin transcripts containing 5' flanking and structural gene sequences. Nucleic Acids Res (1988) 0.75
5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell (2017) 0.75
Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci U S A (2001) 13.30
Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA (2001) 10.63
The E2F transcription factor is a cellular target for the RB protein. Cell (1991) 9.62
Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell (1981) 9.38
Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (1993) 6.84
Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product. Cell (1982) 6.78
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev (2000) 6.54
Identification of a cellular transcription factor involved in E1A trans-activation. Cell (1986) 6.36
Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell (1978) 6.36
Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol (1995) 6.26
The pathway of eukaryotic mRNA formation. Annu Rev Biochem (1983) 6.16
Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell (1983) 5.91
Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A (1997) 5.83
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev (1992) 5.73
Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol (2001) 5.03
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev (1994) 4.93
Requirement of a downstream sequence for generation of a poly(A) addition site. Cell (1984) 4.87
Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol Cell Biol (1984) 4.76
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control. Proc Natl Acad Sci U S A (1987) 4.68
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J (1997) 4.61
Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing. Nature (1981) 4.46
The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A (1992) 4.27
Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection. Mol Cell Biol (1983) 4.15
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell (1991) 3.98
Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A (1995) 3.95
Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation. Cell (1988) 3.91
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell (1990) 3.77
E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc Natl Acad Sci U S A (1989) 3.67
Definition and mapping of adenovirus 2 nuclear transcription. Methods Enzymol (1980) 3.67
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell (1992) 3.64
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol (1995) 3.55
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev (1998) 3.48
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev (2001) 3.41
Activation of early adenovirus transcription by the herpesvirus immediate early gene: evidence for a common cellular control factor. Proc Natl Acad Sci U S A (1982) 3.29
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription. Proc Natl Acad Sci U S A (1985) 3.15
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J (1990) 3.07
An ordered pathway of assembly of components required for polyadenylation site recognition and processing. Genes Dev (1989) 2.94
Regulation of the primary expression of the early adenovirus transcription units. J Virol (1979) 2.92
Ras enhances Myc protein stability. Mol Cell (1999) 2.91
Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation. Mol Cell Biol (1984) 2.88
The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding. Mol Cell Biol (1989) 2.83
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature (1997) 2.78
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J (1993) 2.70
Sequences capable of restoring poly(A) site function define two distinct downstream elements. EMBO J (1986) 2.69
Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites. Mol Cell Biol (1985) 2.65
E1A transcription induction: enhanced binding of a factor to upstream promoter sequences. Science (1986) 2.49
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48
The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol (1996) 2.47
The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein. Cell (1981) 2.44
Multiple factors are required for specific RNA cleavage at a poly(A) addition site. Genes Dev (1988) 2.43
Regulation of early adenovirus transcription: a protein product of early region 2 specifically represses region 4 transcription. Proc Natl Acad Sci U S A (1980) 2.42
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A (1998) 2.40
Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. EMBO J (1987) 2.40
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev (1991) 2.40
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A (1996) 2.36
Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells. Mol Cell Biol (1983) 2.36
Poly(A) site efficiency reflects the stability of complex formation involving the downstream element. EMBO J (1991) 2.30
Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J (1987) 2.30
Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A (1996) 2.30
Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell (1987) 2.29
Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell (2001) 2.29
Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A (1994) 2.24
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol (2000) 2.24
Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control. Proc Natl Acad Sci U S A (1988) 2.16
Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA. Mol Cell Biol (1991) 2.15
Transcription units of adenovirus type 2. Termination of transcription beyond the poly(A) addition site in early regions 2 and 4. J Mol Biol (1980) 2.11
An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc Natl Acad Sci U S A (1990) 2.09
Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development. Genes Dev (1987) 2.07
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev (1996) 2.06
Groups of adenovirus type 2 mRNA's derived from a large primary transcript: probable nuclear origin and possible common 3' ends. J Virol (1978) 2.06
The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. J Mol Biol (1979) 2.04
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia (2010) 2.01
Cell cycle control of the human HSP70 gene: implications for the role of a cellular E1A-like function. Mol Cell Biol (1985) 2.01
The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation. Cell (1991) 2.00
Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol Cell Biol (1997) 2.00
Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene (2009) 1.99
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ (1998) 1.96
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev (1995) 1.95
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development (1999) 1.92
Role of E2F transcription factor in E1A-mediated trans activation of cellular genes. J Virol (1991) 1.92
Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol Cell (2000) 1.86
Isolation and properties of the vaccinia virus DNA-dependent RNA polymerase. J Biol Chem (1977) 1.85
Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. J Biol Chem (2001) 1.85
Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies. Leukemia (2013) 1.84
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol (1996) 1.83
N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. J Mol Biol (1979) 1.82
Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Proc Natl Acad Sci U S A (1995) 1.81
A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A (1999) 1.80
Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid. Mol Cell Biol (1982) 1.79
Poly (A) sequences of vaccinia virus messenger RNA: nature, mode of addition and function during translation in vitra and in vivo. Virology (1975) 1.79