Published in Proc Natl Acad Sci U S A on May 01, 1989
Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol (1995) 6.26
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol (1994) 4.36
Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol Cell Biol (1989) 4.10
Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A (1995) 3.95
The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75
Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol Cell Biol (1992) 3.58
Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J Virol (1992) 3.41
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol (1993) 3.17
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J (1990) 3.07
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99
The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex. Mol Cell Biol (1994) 2.99
CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol (1999) 2.84
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol Cell Biol (1992) 2.78
Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J (2007) 2.75
Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev (1999) 2.73
The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol (1995) 2.70
B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J (1995) 2.51
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol (1994) 2.44
STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med (1999) 2.36
Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol Cell Biol (1993) 2.34
Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo. Mol Cell Biol (1996) 2.16
Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci U S A (2000) 2.15
Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J (1994) 2.14
c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol (2001) 2.10
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Natl Acad Sci U S A (1994) 2.08
Yin-yang 1 activates the c-myc promoter. Mol Cell Biol (1993) 2.06
E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection. Mol Cell Biol (1992) 2.01
In vivo association of E2F and DP family proteins. Mol Cell Biol (1995) 1.99
Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol Cell Biol (1993) 1.98
Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. Mol Cell Biol (1997) 1.95
In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol Cell Biol (1995) 1.93
Role of E2F transcription factor in E1A-mediated trans activation of cellular genes. J Virol (1991) 1.92
DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period. EMBO J (1994) 1.88
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol (1995) 1.87
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol (1993) 1.75
Transcriptional repression by the Rb-related protein p107. Mol Biol Cell (1993) 1.72
Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. Proc Natl Acad Sci U S A (1996) 1.72
A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proc Natl Acad Sci U S A (1995) 1.71
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev (2002) 1.70
Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J Virol (1996) 1.43
Kinase cascades regulating entry into apoptosis. Microbiol Mol Biol Rev (1997) 1.39
Multiple functional elements comprise a Mammalian chromosomal replicator. Mol Cell Biol (2003) 1.36
An essential domain of the c-myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation. Mol Cell Biol (1995) 1.34
The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol Cell Biol (1997) 1.33
Myc oncogenes: the enigmatic family. Biochem J (1996) 1.32
Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol (1993) 1.31
Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters. Mol Cell Biol (1993) 1.29
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. Gastroenterology (2008) 1.29
HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. EMBO J (1994) 1.28
Network calisthenics: control of E2F dynamics in cell cycle entry. Cell Cycle (2011) 1.25
Strategic attack on host cell gene expression during adenovirus infection. J Virol (2003) 1.21
The Epstein-Barr virus protein BRLF1 activates S phase entry through E2F1 induction. J Virol (1999) 1.20
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Mol Cell Biol (2002) 1.18
Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells. Mol Cell Biol (1993) 1.16
p21 Disrupts the interaction between cdk2 and the E2F-p130 complex. Mol Cell Biol (1996) 1.16
Reciprocal regulation of the Epstein-Barr virus BamHI-F promoter by EBNA-1 and an E2F transcription factor. Mol Cell Biol (1994) 1.14
v-Abl activates c-myc transcription through the E2F site. Mol Cell Biol (1995) 1.13
Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen. J Virol (1993) 1.12
Expression and interactions of human adenovirus oncoproteins. Biochem J (1991) 1.10
Multiple change in E2F function and regulation occur upon muscle differentiation. Mol Cell Biol (1995) 1.10
E1A-dependent trans-activation of the c-fos promoter requires the TATAA sequence. Proc Natl Acad Sci U S A (1990) 1.08
Temporal regulation of cyclin A-p107 and p33cdk2 complexes binding to a human thymidine kinase promoter element important for G1-S phase transcriptional regulation. Proc Natl Acad Sci U S A (1993) 1.08
Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network. BMC Syst Biol (2008) 1.05
DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene. Nucleic Acids Res (2004) 1.04
Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity. J Virol (1991) 1.03
Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1. J Virol (1994) 1.03
Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter. Mol Cell Biol (1992) 1.02
YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity. Mol Cell Biol (1996) 1.01
Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity. Mol Cell Biol (2004) 1.01
Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. Hepatology (2013) 0.99
Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet (2010) 0.99
Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and promoter mutagenesis. Mol Cell Biol (1993) 0.99
Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci U S A (2009) 0.95
The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcription. J Virol (1990) 0.93
Design of a novel triple helix-forming oligodeoxyribonucleotide directed to the major promoter of the c-myc gene. Nucleic Acids Res (2002) 0.93
E2F is required to prevent inappropriate S-phase entry of mammalian cells. Mol Cell Biol (2000) 0.93
Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Res (2013) 0.92
Simian virus 40 small-t does not transactivate RNA polymerase II promoters in virus infections. J Virol (1991) 0.92
Interacting domains of E2F1, DP1, and the adenovirus E4 protein. J Virol (1994) 0.92
Elongation and maturation of c-myc RNA is inhibited by differentiation inducing agents in HL60 cells. Nucleic Acids Res (1990) 0.91
Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity. Oncogene (2006) 0.91
Xenopus laevis c-myc I and II genes: molecular structure and developmental expression. Nucleic Acids Res (1991) 0.91
A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication. J Virol (2002) 0.91
The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are essential and sufficient for E2F complex formation. Nucleic Acids Res (1991) 0.90
Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish. Toxicol Appl Pharmacol (2012) 0.88
Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. J Cell Biol (2000) 0.88
Mutual interference of adenovirus infection and myc expression. J Virol (2003) 0.87
Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor. Mol Biol Cell (1995) 0.86
Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation. Proc Natl Acad Sci U S A (1993) 0.85
Antitumor mechanisms when pRb and p53 are genetically inactivated. Oncogene (2014) 0.81
Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J (1995) 0.81
Repression of Epstein-Barr virus EBNA-1 gene transcription by pRb during restricted latency. J Virol (1999) 0.80
Defective expression of adenovirus genes during early infection of undifferentiated OTF963 embryonal carcinoma cells. J Virol (1990) 0.79
Anti-cancer-prostaglandin-induced cell-cycle arrest and its modulation by an inhibitor of the ATP-dependent glutathione S-conjugate export pump (GS-X pump). Biochem J (1998) 0.78
The human papillomavirus E7 oncoprotein as a regulator of transcription. Virus Res (2016) 0.76
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (1983) 11.61
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (1986) 8.64
Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses. Genes Dev (1988) 7.52
Identification of a cellular transcription factor involved in E1A trans-activation. Cell (1986) 6.36
Adenovirus promoters and E1A transactivation. Annu Rev Genet (1986) 5.86
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control. Proc Natl Acad Sci U S A (1987) 4.68
Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation. Cell (1988) 3.91
A TATA box implicated in E1A transcriptional activation of a simple adenovirus 2 promoter. Nature (1987) 3.81
Definition and mapping of adenovirus 2 nuclear transcription. Methods Enzymol (1980) 3.67
Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus. Nature (1982) 3.64
Adenovirus EIIA early promoter: transcriptional control elements and induction by the viral pre-early EIA gene, which appears to be sequence independent. Proc Natl Acad Sci U S A (1985) 3.32
Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. Science (1984) 3.24
Expression and characterization of the human c-myc DNA-binding protein. Mol Cell Biol (1985) 3.24
DNA-bound Fos proteins activate transcription in yeast. Cell (1988) 3.22
Enhancement of RNA polymerase III transcription by the E1A gene product of adenovirus. Cell (1985) 3.21
The adenovirus-2 early EIIa transcription unit possesses two overlapping promoters with different sequence requirements for EIa-dependent stimulation. EMBO J (1985) 2.89
Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation. Mol Cell Biol (1984) 2.88
The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding. Mol Cell Biol (1989) 2.83
Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. EMBO J (1987) 2.40
Nucleotide sequence comparison of normal and translocated murine c-myc genes. Nature (1984) 2.31
Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J (1987) 2.30
Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell (1987) 2.29
Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control. Proc Natl Acad Sci U S A (1988) 2.16
Transcription of class III genes activated by viral immediate early proteins. Science (1985) 2.10
Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Mol Cell Biol (1985) 2.09
Differential activation of RNA polymerase III-transcribed genes by the polyomavirus enhancer and the adenovirus E1A gene products. Nucleic Acids Res (1985) 1.72
Target sequences for cis-acting regulation within the dual promoter of the human c-myc gene. Mol Cell Biol (1987) 1.63
Promoter trans-activation of protooncogenes c-fos and c-myc, but not c-Ha-ras, by products of adenovirus early region 1A. Proc Natl Acad Sci U S A (1987) 1.38
Regulation of early adenovirus gene expression. Microbiol Rev (1987) 1.34
Sequences involved in accurate and efficient transcription of human c-myc genes microinjected into frog oocytes. Mol Cell Biol (1986) 1.06
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47
Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci U S A (2001) 13.30
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell (1999) 12.50
The E2F transcription factor is a cellular target for the RB protein. Cell (1991) 9.62
Mechanism of activation of early viral transcription by the adenovirus E1A gene product. Cell (1981) 9.38
Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature (2001) 7.90
A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature (2000) 6.89
Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (1993) 6.84
Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product. Cell (1982) 6.78
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med (2000) 6.57
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev (2000) 6.54
Identification of a cellular transcription factor involved in E1A trans-activation. Cell (1986) 6.36
Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell (1978) 6.36
Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol (1995) 6.26
The pathway of eukaryotic mRNA formation. Annu Rev Biochem (1983) 6.16
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med (2000) 6.06
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell (1996) 5.97
Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element. Cell (1983) 5.91
Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A (1997) 5.83
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev (1992) 5.73
Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol (2001) 5.03
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev (1994) 4.93
Requirement of a downstream sequence for generation of a poly(A) addition site. Cell (1984) 4.87
Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity. Mol Cell Biol (1984) 4.76
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control. Proc Natl Acad Sci U S A (1987) 4.68
Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing. Nature (1981) 4.46
The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci U S A (1992) 4.27
Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection. Mol Cell Biol (1983) 4.15
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell (1991) 3.98
Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A (1995) 3.95
Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation. Cell (1988) 3.91
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell (1990) 3.77
Definition and mapping of adenovirus 2 nuclear transcription. Methods Enzymol (1980) 3.67
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell (1992) 3.64
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol (1995) 3.55
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev (1998) 3.48
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev (2001) 3.41
Activation of early adenovirus transcription by the herpesvirus immediate early gene: evidence for a common cellular control factor. Proc Natl Acad Sci U S A (1982) 3.29
CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity (2000) 3.28
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription. Proc Natl Acad Sci U S A (1985) 3.15
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J (1990) 3.07
Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol (1999) 3.04
An ordered pathway of assembly of components required for polyadenylation site recognition and processing. Genes Dev (1989) 2.94
Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood (1994) 2.93
Regulation of the primary expression of the early adenovirus transcription units. J Virol (1979) 2.92
Ras enhances Myc protein stability. Mol Cell (1999) 2.91
Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation. Mol Cell Biol (1984) 2.88
The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding. Mol Cell Biol (1989) 2.83
Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter. Genes Dev (1989) 2.82
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature (1997) 2.78
NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. EMBO J (2000) 2.76
Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences. Cell (1985) 2.72
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J (1993) 2.70
Sequences capable of restoring poly(A) site function define two distinct downstream elements. EMBO J (1986) 2.69
Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites. Mol Cell Biol (1985) 2.65
E1A transcription induction: enhanced binding of a factor to upstream promoter sequences. Science (1986) 2.49
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48
The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol (1996) 2.47
The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein. Cell (1981) 2.44
Multiple factors are required for specific RNA cleavage at a poly(A) addition site. Genes Dev (1988) 2.43
Regulation of early adenovirus transcription: a protein product of early region 2 specifically represses region 4 transcription. Proc Natl Acad Sci U S A (1980) 2.42
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A (1998) 2.40
Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter. EMBO J (1987) 2.40
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. Genes Dev (1991) 2.40
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A (1996) 2.36
Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells. Mol Cell Biol (1983) 2.36
Poly(A) site efficiency reflects the stability of complex formation involving the downstream element. EMBO J (1991) 2.30
Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J (1987) 2.30
Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A (1996) 2.30
Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell (1987) 2.29
Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell (2001) 2.29
Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A (1994) 2.24
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol (2000) 2.24
Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J Immunol (1998) 2.22
Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control. Proc Natl Acad Sci U S A (1988) 2.16
Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med (1999) 2.15
Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA. Mol Cell Biol (1991) 2.15
Transcription units of adenovirus type 2. Termination of transcription beyond the poly(A) addition site in early regions 2 and 4. J Mol Biol (1980) 2.11
An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc Natl Acad Sci U S A (1990) 2.09
Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development. Genes Dev (1987) 2.07
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev (1996) 2.06
Groups of adenovirus type 2 mRNA's derived from a large primary transcript: probable nuclear origin and possible common 3' ends. J Virol (1978) 2.06
The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. J Mol Biol (1979) 2.04
Cell cycle control of the human HSP70 gene: implications for the role of a cellular E1A-like function. Mol Cell Biol (1985) 2.01
Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol (1999) 2.01
The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation. Cell (1991) 2.00
Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol Cell Biol (1997) 2.00
Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene (2009) 1.99
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ (1998) 1.96
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev (1995) 1.95
Role of E2F transcription factor in E1A-mediated trans activation of cellular genes. J Virol (1991) 1.92
Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol Cell (2000) 1.86
Isolation and properties of the vaccinia virus DNA-dependent RNA polymerase. J Biol Chem (1977) 1.85
Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. J Biol Chem (2001) 1.85
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol (1996) 1.83
N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA. J Mol Biol (1979) 1.82
Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Proc Natl Acad Sci U S A (1995) 1.81
A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A (1999) 1.80